The HPV16 E6 Oncoprotein Causes Prolonged Receptor Protein Tyrosine Kinase Signaling and Enhances Internalization of Phosphorylated Receptor Species [PDF]
, 2013 The high-risk human papillomavirus (HPV) E6 proteins are consistently expressed in HPV-associated lesions and cancers. HPV16 E6 sustains the activity of the mTORC1 and mTORC2 signaling cascades under conditions of growth factor deprivation.
Munger, Karl, Spangle, Jennifer Marie
core +3 more sources
Breast Cancer: Basic and Clinical Research, 2009 Biomarkers of breast cancer are necessary for prognosis and prediction to chemotherapy. Prognostic biomarkers provide information regarding outcome irrespective of therapy, while predictive biomarkers provide information regarding response to therapy ...
Siddik Sarkar, Mahitosh Mandal
doaj
Pulmonary Circulation, 2020 Platelet-derived growth factor is one of the major growth factors found in human and mammalian serum and tissues. Abnormal activation of platelet-derived growth factor signaling pathway through platelet-derived growth factor receptors may contribute to ...
Kang Wu +21 more
doaj +1 more source
From Tumor to Bone: Growth Factor Receptors as Key Players in Cancer Metastasis
Frontiers in Bioscience-LandmarkThis review article explores the intricate correlation between growth factors and bone metastases, which play a crucial role in the development of several types of malignancies, namely breast, prostate, lung, and renal cancers.
Khalid Said Mohammad +1 more
doaj +1 more source
Tumor Biology, 2017 The use of trastuzumab in patients with breast cancer that overexpresses human epidermal growth factor receptor 2 has significantly improved treatment outcomes.
Marianne Nordlund Broughton +6 more
doaj +1 more source
NRF2 regulates HER1 signaling pathway to modulate the sensitivity of ovarian cancer cells to lapatinib and erlotinib [PDF]
, 2017 NF-E2-related factor 2 (NRF2) regulates the transcription of a battery of metabolic and cytoprotective genes. NRF2 and epidermal growth factor receptors (EGFRs/HERs) are regulators of cellular proliferation and determinants of cancer initiation and ...
Bown, James L. +5 more
core +6 more sources
The beneficial effect of suramin on monocrotaline-induced pulmonary hypertension in rats. [PDF]
PLoS ONE, 2013 BACKGROUND:Pulmonary hypertension (PH) is a progressive disorder characterized by an increase in pulmonary artery pressure and structural changes in the pulmonary vasculature.
Mohamed Izikki +11 more
doaj +1 more source
Growth factors and experimental arterial grafts [PDF]
, 2016 Background: The production of growth factors from several experimental arterial conduits was determined. Methods: We implanted 105 experimental arterial grafts that were 1 cm long in the abdominal aorta of Lewis rats (average weight, 250 g).
BORRELLI, Valeria +6 more
core +1 more source
The insulin-like growth factor system and its receptors: A potential novel anticancer target
Biologics: Targets & Therapy, 2008 Colin R. Lindsay1, T R Jeffry Evans1,21Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom; 2University of Glasgow, CR-UK Beatson Laboratories, Garscube Estate, Glasgow, United KingdomAbstract: The current generation of novel anticancer ...
Colin R. Lindsay, T R Jeffry Evans
doaj
Reversal of age-related learning deficiency by the vertebrate PACAP and IGF-1 in a novel invertebrate model of aging: the pond snail (Lymnaea Stagnalis) [PDF]
, 2014 With the increase of life span, nonpathological age-related memory decline is affecting an increasing number of people. However, there is evidence that age-associated memory impairment only suspends, rather than irreversibly extinguishes, the intrinsic ...
Alexander +38 more
core +2 more sources