Results 81 to 90 of about 2,825,424 (355)

Transforming growth factor-β receptors: versatile mechanisms of ligand activation

Transforming growth factor-β (TGF-β) signaling is initiated by activation of transmembrane TGF-β receptors (TGFBR), which deploys Smad2/3 transcription factors to control cellular responses.
Kamato, Danielle, Cao, Ying-nan, Little, Peter J, Chia, Zheng-Jie   +3 more
core   +1 more source

Placental growth factor promotes atherosclerotic intimal thickening and macrophage accumulation

, 2005
Background: Placental growth factor (PlGF) has been implicated in the pathophysiological angiogenesis and monocyte recruitment that underlie chronic inflammatory disease, but its role in atherosclerosis has not been examined.
Collen, Desire, Moons, L., Carmeliet, P, Zachary, IC, Khurana, R, Martin, JF, Zachary, I.C., Khurana, Rohit, Luttun, A, Martin, John F., Martin, J.F., Zachary, Ian C., Shafi, S, Shafi, S., Collen, D., Khurana, R., Shafi, Shahida, Luttun, A., Carmeliet, Peter, Luttun, Aernout, Moons, L, Moons, Lieve, Carmeliet, P.   +22 more
core   +1 more source

Growth Factors in Human Ovarian Follicle Fluid and Growth Factor Receptors in Granulosa-Luteal Cells

The International Journal of Biological Markers, 1995
The levels of oestradiol (E 2 ), progesterone (P 4 ), transforming growth factor a (TGFa), transforming growth factor β2 (TGFβ 2 ), insulin-like growth factor I (IGF-I), platelet-derived growth factor AB (PDGF-AB) and epidermal growth factor (EGF) were ...
R. McWilliam, R.E. Leake, J.R.T. Coutts
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Chimeric vitronectin:insulin-like growth factor proteins enhance cell growth and migration through co-activation of receptors

, 2007
Complexes comprised of IGF-I, IGF-binding proteins and the ECM protein vitronectin (VN) stimulate cell migration and growth and can replace the requirement for serum for the ex vivo expansion of cells, as well as promote wound healing in vivo.
Hollier, Brett G., Derek R. Van Lonkhuyzen, Gary K. Shooter, Brett G. Hollier, Leavesley, David I., David I. Leavesley, Zee Upton, Van Lonkhuyzen, Derek R., Upton, Zee, Shooter, Gary K.   +9 more
core   +1 more source

Suppression of neurite outgrowth by high-dose nerve growth factor is independent of functional p75NTR receptors

Neurobiology of Disease, 2004
We have previously demonstrated that high concentrations of nerve growth factor suppress neurite outgrowth from sensory neurons. Inhibition could be mediated by either the p75NTR or TrkA receptor.
Anna M. Conti, Stephen Brimijoin, Laurence J. Miller, Anthony J. Windebank   +3 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

GROWTH FACTOR AND ADIPOKINE RECEPTORS IN PATHOGENESIS AND PROGNOSIS OF ENDOMETRIAL CANCER IN PATIENTS WITH METABOLIC SYNDROME

Сибирский онкологический журнал, 2016
The role of growth factor receptors (insulin-like growth factor and transforming growth factor-beta) and adipokine receptors (leptin and adiponectin) in pathogenesis of endometrial cancer under conditions of metabolic syndrome is discussed ...
N. V. Yunusova, I. V. Kondakova, L. А. Kolomiets, А. L. Chernyshova, Е. V. Shanshashvili   +4 more
doaj  

Cross-Talk between Fibroblast Growth Factor Receptors and Other Cell Surface Proteins

Cells, 2019
Fibroblast growth factors (FGFs) and their receptors (FGFRs) constitute signaling circuits that transmit signals across the plasma membrane, regulating pivotal cellular processes like differentiation, migration, proliferation, and apoptosis.
Marta Latko, Aleksandra Czyrek, Natalia Porębska, Marika Kucińska, Jacek Otlewski, Małgorzata Zakrzewska, Łukasz Opaliński   +6 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source