Results 191 to 200 of about 89,612 (317)

Histamine and TH2 cytokines regulate the biosynthesis of cysteinyl-leukotrienes and expression of their receptors in human mast cells. [PDF]

Inflamm Res
Gehlhaar P, Schaper-Gerhardt K, Gutzmer R, Hasler F, Röhn TA, Werfel T, Mommert S.   +6 more
europepmc   +1 more source

Approach to the Management of Gastrointestinal Manifestations in Patients With Phaeochromocytoma and Paraganglioma

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Managing gastrointestinal symptoms in patients with phaeochromocytoma and paraganglioma (PPGL) is challenging due to the risk of catecholaminergic crisis with many commonly prescribed medications, especially in functional tumours.
Monica Majumder, Cherie Chiang, Grace Kong, Michael Michael, Nirupa Sachithanandan, Emma Boehm   +5 more
wiley   +1 more source

Modafinil Ameliorated Fibromyalgia Syndrome in Rats by Modulating Mast Cells and Microglia Activation Through Dopamine/Substance P/MRGPRX/Histamine and PI3K/p-Akt/NF-κB Signaling Pathways. [PDF]

J Neuroimmune Pharmacol
Kamal MM, Essam RM, Abdelkader NF, Zaki HF.   +3 more
europepmc   +1 more source

Infantile Cerebellar‐Retinal Degeneration Associated With Novel ACO2 Variants: Clinical Features and Insights From a Drosophila Model

Clinical Genetics, EarlyView.
Our Translational Loop integrates patient genetic data with Drosophila models to study disease mechanisms. We identified ACO2 variants in a patient linked to ICRD and show that our animal model mirrors key aspects of the disease. These insights help pinpoint therapeutic targets, advancing research toward treatments for rare genetic disorders.
Edgar Buhl, Suchika Garg, Marie Monaghan, Amy Preston, Marcus Likeman, Julianne Dare, Julie Evans, Lucie S. Taylor, Ian Berry, Kathryn Urankar, Paul G. D. Spry, Cathy Williams, Robert W. Taylor, Charlotte L. Alston, James J. L. Hodge, Anirban Majumdar   +15 more
wiley   +1 more source

Biogenic Amine Metabolism and Its Genetic Variations in Autism Spectrum Disorder: A Comprehensive Overview. [PDF]

Biomolecules
Tabolacci C, Caruso A, Micai M, Galati G, Lintas C, Pisanu ME, Scattoni ML.   +6 more
europepmc   +1 more source

Contact Urticaria and Related Conditions: Clinical Review

Contact Dermatitis, EarlyView.
ABSTRACT Contact urticaria (CoU) is an immediate contact reaction occurring within minutes to an hour after exposure to specific proteins or chemicals. CoU is categorised into non‐immunologic (NI‐CoU) and immunologic (I‐CoU) types, with I‐CoU potentially leading to anaphylaxis. Both forms of CoU can be associated with protein contact dermatitis and the
Mojca Bizjak, Olivier Aerts, David Pesqué, Melba Muñoz, Riccardo Asero, Margarida Gonçalo, Thomas Rustemeyer, Mitja Košnik, Mark Kačar, An Goossens, Jose Hernán Alfonso, Charlotte G. Mortz, Maryam Ali Al‐Nesf, Joachim W. Fluhr, Howard I. Maibach, Ana Maria Giménez‐Arnau   +15 more
wiley   +1 more source

Histamine Modulation of the Basal Ganglia Circuitry in the Motor Symptoms of Parkinson's Disease. [PDF]

CNS Neurosci Ther
Zhu HX, Lou WW, Jiang YM, Ciobanu A, Fang CX, Liu CY, Yang YL, Cao JY, Shan L, Zhuang QX.   +9 more
europepmc   +1 more source

High detection rate for perivascular deposits of immunoglobulins in immune complex vasculitis from biopsies of early macular lesions

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 23, Issue 4, Page 479-485, April 2025.
Summary Background In immune complex vasculitis the detection of perivascular immunoglobulins by direct immunofluorescence (DIF) not only helps to confirm the diagnosis, but also to define the type of vasculitis (e.g., IgA‐, IgG/IgM‐, rheumatoid or cryoglobulinemic vasculitis).
Luisa Herda, Christiane Michl, Cord Sunderkötter   +2 more
wiley   +1 more source

Histamine: A key compound in red light-enhanced <i>Fusarium verticillioides</i> resistance in maize. [PDF]

Imeta
Feng X, Zheng D, Zhang W, Xiao H, Guan H, Xiong H, Jia L, Zhang X, Wang W, Wang H, Lu Y.   +10 more
europepmc   +1 more source

The human photosensitive epilepsy model for clinical proof‐of‐principle trials of novel antiseizure medications: 2. Analysis of drug trials and predictive value of the model

Epilepsia, EarlyView.
Abstract Clinical development of novel antiseizure medications (ASMs) would benefit from an early proof of principle (POP) model. The photosensitivity model, which uses the photoparoxysmal electroencephalographic response (PPR) as a surrogate of seizures, is currently the only human model that allows POP trials of investigational compounds after a ...
Wolfgang Löscher, Dorothée Kasteleijn‐Nolst Trenité   +1 more
wiley   +1 more source