Results 211 to 220 of about 49,569 (265)
Some of the next articles are maybe not open access.
Histamine and Histamine Receptors in Allergic Dermatitis
2016In this chapter we will first introduce the pathophysiological process of several skin diseases including allergic dermatitis, a common skin disease, including chronic allergic contact dermatitis (CACD), and atopic dermatitis (AD). In CACD and AD patients, repeated skin exposure to antigens contributes to the development of chronic eczematous lesions ...
Hiroshi, Ohtsu, Masahiro, Seike
openaire +2 more sources
Histamine and Histamine Receptor Antagonists in Cancer Biology
Inflammation & Allergy - Drug Targets, 2010Histamine has been demonstrated to be involved in cell proliferation, embryonic development, and tumour growth. These various biological effects are mediated through the activation of specific histamine receptors (H1, H2, H3, and H4) that differ in their tissue expression patterns and functions.
Bruno, Blaya +8 more
openaire +2 more sources
Histamine, histamine receptors and their role in immune pathology
Clinical & Experimental Allergy, 2009SummaryThe important roles of histamine in body physiology and various pathologic events have been well established, whereas new and exciting findings are still being uncovered. Histamine is not only the major mediator of the acute inflammatory and immediate hypersensitivity responses, but has also been demonstrated to affect chronic inflammation and ...
Jutel, M, Akdis, M, Akdis, C A
openaire +3 more sources
Histamine Receptors in the Lung
Allergy and Asthma Proceedings, 1987The availability of specific histamine receptor antagonists has provided evidence that human airways have both H1 and H2 receptors. H1 receptors, which mediate bronchoconstriction, predominate. H1 receptor antagonism can produce significant bronchodilatation in some asthmatics, block bronchoconstriction induced by antigen and histamine inhalation ...
openaire +2 more sources
Histamine Receptors in the Lung
1991Histamine, which has long been implicated as a mediator of allergic airway disease, has multiple effects on airways which are mediated by at least three histamine receptors. H1-receptors mediate bronchoconstriction, vasoconstriction and dilatation, microvascular leak and activation of sensory nerves.
openaire +2 more sources
Histamine receptors are hot in immunopharmacology
European Journal of Pharmacology, 2006In addition to its well-characterized effects in the acute allergic inflammatory responses, histamine has been demonstrated to affect chronic inflammation and regulate several essential events in the immune response. Histamine can selectively recruit the major effector cells into tissue sites and affect their maturation, activation, polarization, and ...
Akdis CA, Simons FE
openaire +3 more sources
The new biology of histamine receptors
Current Allergy and Asthma Reports, 2008The physiologic functions of histamine have been recognized for more than 100 years, yet new roles are still being uncovered. Most importantly, a newly discovered receptor of the amine has helped refine our understanding of histamine. This new receptor, the histamine H4 receptor (H4R), has a higher affinity for histamine compared with the histamine H1 ...
Jing-Feng, Huang, Robin L, Thurmond
openaire +2 more sources
Histamine H3 Receptor Agonists
Mini-Reviews in Medicinal Chemistry, 2004The SAR of H3 ligands has been difficult to evaluate because of species differences, multiple isoforms and constitutive activity, among other complicating factors. A review is given of the sometimes-conflicting affinity, activity and efficacy data of H3 agonists that has been described in literature to date.
I J P, De Esch, K J, Belzar
openaire +2 more sources
Histamine H4 receptor agonists
Bioorganic & Medicinal Chemistry Letters, 2010Since its discovery 10 years ago the histamine H(4) receptor (H(4)R) has attracted attention as a potential drug target, for instance, for the treatment of inflammatory and allergic diseases. Potent and selective ligands including agonists are required as pharmacological tools to study the role of the H(4)R in vitro and in vivo.
Patrick, Igel +2 more
openaire +2 more sources
2002
Abstract Histamine [2-(4-imidazolyl)ethylamine, HA] is an endogenous biogenic amine synthesized in and released from several kinds of cells, and involved in many kinds of biological signalling (Uvnas 1991). Mast cells (a family of bone marrow-derived secretory cells) store much of the body’s HA in very high concentrations.
Lindsay B Hough, Rob Leurs
openaire +1 more source
Abstract Histamine [2-(4-imidazolyl)ethylamine, HA] is an endogenous biogenic amine synthesized in and released from several kinds of cells, and involved in many kinds of biological signalling (Uvnas 1991). Mast cells (a family of bone marrow-derived secretory cells) store much of the body’s HA in very high concentrations.
Lindsay B Hough, Rob Leurs
openaire +1 more source