Results 31 to 40 of about 53,739 (211)

Efficacy of the Multi-Target Compound E153 in Relieving Pain and Pruritus of Different Origins

Pharmaceuticals, 2023
Itch and pain are closely related but distinct sensations that share largely overlapping mediators and receptors. We hypothesized that the novel, multi-target compound E153 has the potential to attenuate pain and pruritus of different origins.
Szczepan Mogilski, Monika Kubacka, Artur Świerczek, Elżbieta Wyska, Katarzyna Szczepańska, Jacek Sapa, Katarzyna Kieć-Kononowicz, Dorota Łażewska   +7 more
doaj   +1 more source

Investigations on neuropeptide Y and histamine receptors by fluorescence-based and radiochemical methods

, 2011
In the last three decades, a large amount of experimental data (for example Förster resonance energy transfer (FRET) at fluorescently labelled receptors) supported the hypothesis of the dimerization of G-protein-coupled receptors (GPCR), including ...
Lopuch, Miroslaw
core   +1 more source

Delineating the role of histamine-1- and -4-receptors in a mouse model of Th2-dependent antigen-specific skin inflammation. [PDF]

PLoS ONE, 2014
BACKGROUND: Histamine drives pruritus in allergic skin diseases which clinically constitutes a most disruptive symptom. Skin pathology in allergic skin diseases is crucially influenced by different T-helper subsets. However, the contribution of different
Subhashree Mahapatra, Melanie Albrecht, Barbara Behrens, Adan Jirmo, Georg Behrens, Christina Hartwig, Detlef Neumann, Ulrike Raap, Heike Bähre, Christina Herrick, Anna-Maria Dittrich   +10 more
doaj   +1 more source

Perioperative uses of histamine antagonists

, 1990
Histamine release and adverse pseudoallergic/allergic reactions during the perioperative period occur frequently. The incidence of such reactions is 20%-30% for all grades of severity, 1%-5% for systemic reactions, and 0.1%-0.5% for life-threatening ...
Lorenz, Wilfried, Doenicke, A., Ennis, M., Dick, W.   +3 more
core   +1 more source

Remission maintenance in acute myeloid leukemia: impact of functional histamine H2 receptors expressed by leukemic cells

Haematologica, 2012
Post-consolidation immunotherapy with histamine dihydrochloride and interleukin-2 has been shown to improve leukemia-free survival in acute myeloid leukemia in a phase III trial.
Johan Aurelius, Anna Martner, Mats Brune, Lars Palmqvist, Markus Hansson, Kristoffer Hellstrand, Fredrik B. Thoren   +6 more
doaj   +1 more source

Plasticity of histamine H3 receptor expression and binding in the vestibular nuclei after labyrinthectomy in rat

, 2004
Background: In rat, deafferentation of one labyrinth (unilateral labyrinthectomy) results in a characteristic syndrome of ocular and motor postural disorders (e.g., barrel rotation, circling behavior, and spontaneous nystagmus). Behavioral recovery (e.g.,
Panula, Pertti, Lozada, Adrian F., Kaj Karlstedt, Karlstedt, Kaj, Aarnisalo, Antti A., Stark, Holger, Adrian F Lozada, Pertti Panula, Antti A Aarnisalo, Holger Stark   +9 more
core   +1 more source

Molecular analysis of the histamine H3-receptor

, 2010
The histamine H3 receptor (H3R) is a biogenic amine receptor that belongs to family I of G protein-coupled receptors (GPCRs). During the past two decades, the H3R has gained much interest in academia and industry.
Schnell, David
core   +1 more source

Histamine enhances ATP-induced itching and responsiveness to ATP in keratinocytes

Journal of Pharmacological Sciences, 2022
Mechanical stimulation of cultured keratinocytes and a living epidermis increases intracellular calcium ion concentrations ([Ca2+]i) in stimulated cells. This action propagates a Ca2+ wave to neighboring keratinocytes via ATP/P2Y2 receptors.
Yoshihiro Inami, Miki Fukushima, Toshiaki Kume, Daisuke Uta   +3 more
doaj   +1 more source

Histamine receptors in GtoPdb v.2023.1

, 2023
Histamine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Histamine Receptors [80, 174]) are activated by the endogenous ligand histamine. Marked species differences exist between histamine receptor orthologues [80]. The human and rat
Hill, Stephen J., Young, J. Michael, Steve Liu, Jean-Charles Schwartz, Shankley, Nigel P., Haas, Helmut L., Holger Stark, Nigel P. Shankley, Robin Thurmond, Paul Chazot, Stephen J. Hill, Fukui, Hiroyuki, Hills, Rebecca, J. Michael Young, Levi, Roberto, Leurs, Rob, Marlon Cowart, Rebecca Hills, Cowart, Marlon, Gutzmer, Ralf, C. Robin Ganellin, Seifert, Roland, Ganellin, C. Robin, Rob Leurs, Roberto Levi, Timmerman, Henk, Stark, Holger, Panula, Pertti, Hiroyuki Fukui, Schunack, Walter, Chazot, Paul, Roland Seifert, Liu, Steve, Schwartz, Jean-Charles, Walter Schunack, Henk Timmerman, Pertti Panula, Helmut L. Haas, Thurmond, Robin, Ralf Gutzmer   +39 more
core   +1 more source

On the Mechanisms Underlying Histamine Induction of Gastric Mucosal Lesions in Rats With Partial Gastric Vascular Occlusion

Journal of Pharmacological Sciences, 2003
Although it is well known that histamine induces gastric mucosal lesions in laboratory animals, the fundamental mechanisms remain unclear. In order to further analyze the vascular mechanisms underlying histamine-induced lesions, a new model was developed
Kikuko Amagase, Susumu Okabe
doaj   +1 more source