Results 31 to 40 of about 618,319 (304)

Targeted therapy with histamine antagonists - New challenges to fight with breast cancer

Journal of Education, Health and Sport, 2022
Breast cancer (BC) is currently the most commonly diagnosed cancer in women. BC is most often derived from the epithelial tissue of the mammary gland and is a global problem due to the steady increase in morbidity and mortality in most countries.
Piotr Jan Więsyk, Paulina Oleksa, Zuzanna Chilimoniuk, Maciej Dobosz, Maciej Sobczyk, Małgorzata Słaboń   +5 more
doaj   +1 more source

Perioperative nonspecific histamine release: a new classification by aetiological mechanisms and evaluation of their clinical relevance [PDF]

, 1993
As a consequence of the performance of a randomized controlled clinical trial on perioperative histamine release and cardiovascular and respiratory disturbances, several types of increases in plasma histamine had to be distinguished instead of only two ...
Lorenz, Wilfried, Schäfer, U., Junginger, T., Stinner, B., Nies, C., Duda, D., Hasse, C., Menke, H., Rothmund, M., Sitter, H.   +9 more
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Highly potent, selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships [PDF]

, 2008
Potent and selective histamine H2 receptor (H2R) agonists are valuable pharmacological tools and might be of therapeutic value as drugs, for example in the treatment of severe congestive heart failure.
Kraus, Anja
core   +1 more source

The Affinity of Histamine for Gq Protein-Coupled Histamine H1-Receptors Is Predominantly Regulated by Their Internalization in Human Astrocytoma Cells

Journal of Pharmacological Sciences, 2012
We examined the regulatory mechanisms of the affinity of Gq protein-coupled histamine H1-receptors for histamine after histamine pretreatment in intact human U373 MG astrocytoma cells.
Shigeru Hishinuma, Yuko Sato, Chizuru Akatsu, Masaru Shoji   +3 more
doaj   +1 more source

Granuloma pouch and skin histamine of the rat [PDF]

, 1958
Using the granuloma pouch technique of SELYE, effect of modification in local histamine on the inflammatory tissue reactions was examined in rats. The increase in the weight of pouch wall and histological inflammatory changes were distinctly inhibited in
Irino, Shozo
core   +1 more source

Differential expression of histamine receptors in the bladder wall tissues of patients with bladder pain syndrome/interstitial cystitis – significance in the responsiveness to antihistamine treatment and disease symptoms

BMC Urology, 2019
Background Activation of mast cells plays an important role in the pathogenesis of bladder pain syndrome/interstitial cystitis (BPS/IC). Histamine, a mast cell-derived mediators, induced inflammation and hypersensitivity of the bladder. The present study
Hui Shan, Er-Wei Zhang, Peng Zhang, Xiao-Dong Zhang, Ning Zhang, Peng Du, Yong Yang   +6 more
doaj   +1 more source

Histamine upregulates the expression of histamine receptors and increases the neuroprotective effect of astrocytes

Journal of Neuroinflammation, 2018
Background Astrocytes have attracted increasing attention over recent decades for their role in neuroinflammation. Histamine, a major aminergic brain neurotransmitter, has an important influence on the main activities of astrocytes, such as ion ...
Jiawen Xu, Xiang Zhang, Qingqing Qian, Yiwei Wang, Hongquan Dong, Nana Li, Yanning Qian, Wenjie Jin   +7 more
doaj   +1 more source

Histamine and migraine revisited: mechanisms and possible drug targets

The Journal of Headache and Pain, 2019
Objective To review the existing literature on histamine and migraine with a focus on the molecule, its receptors, its use in inducing migraine, and antihistamines in the treatment of migraine. Background Histamine has been known to cause a vascular type
Jacob Worm, Katrine Falkenberg, Jes Olesen   +2 more
doaj   +1 more source

Efficacy of the Multi-Target Compound E153 in Relieving Pain and Pruritus of Different Origins

Pharmaceuticals, 2023
Itch and pain are closely related but distinct sensations that share largely overlapping mediators and receptors. We hypothesized that the novel, multi-target compound E153 has the potential to attenuate pain and pruritus of different origins.
Szczepan Mogilski, Monika Kubacka, Artur Świerczek, Elżbieta Wyska, Katarzyna Szczepańska, Jacek Sapa, Katarzyna Kieć-Kononowicz, Dorota Łażewska   +7 more
doaj   +1 more source

Histamine receptors in GtoPdb v.2021.3 [PDF]

, 2021
Histamine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Histamine Receptors [80, 173]) are activated by the endogenous ligand histamine. Marked species differences exist between histamine receptor orthologues [80]. The human and rat
Levi, Roberto, Leurs, Rob, Cowart, Marlon, Hill, Stephen J., Young, J. Michael, Gutzmer, Ralf, Seifert, Roland, Ganellin, C. Robin, Shankley, Nigel P., Timmerman, Henk, Haas, Helmut L., Stark, Holger, Panula, Pertti, Schunack, Walter, Chazot, Paul, Fukui, Hiroyuki, Liu, Steve, Schwartz, Jean-Charles, Hills, Rebecca, Thurmond, Robin   +19 more
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