Results 131 to 140 of about 18,066 (161)

H1and H2 histamine receptors on Aplysia neurones

Nature, 1975
WE have found two types of histamine receptor on neurones of the mollusc Aplysia corresponding to those already known in mammals. The presence of these specific receptors is consistent with the suggestion that histamine acts as a neurotransmitter.
Gary L. Gaubatz, David O. Carpenter
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Histamine H1 and H2-Receptors at a Ganglionic Synapse

Nature, 1973
MANY humoral agents are capable of modulating synaptic transmission in sympathetic ganglia and it has been proposed that a variety of receptors are present at the ganglionic synapse (see Haefely1). There are thus many possible modulatory mechanisms at this synapse, some of which have a dual nature, the same substance being able both to facilitate and ...
M J Brimble, D I Wallis
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Antagonism of tolazoline by histamine H2-receptor blockers

Nature, 1975
TOLAZOLINE (2-benzyl-2-imidazoline), a peripheral vasodilator and adrenergic blocking agent used to treat peripheral vascular disease and (formerly) hypertension, has actions similar to those of histamine, including vasodilation, pressor responses in the rabbit and stimulation of intestinal smooth muscle, gastric secretion and the heart.
Tobias O. Yellin, J. W. Sperow, S. H. Buck   +2 more
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Histamine H1- and H2-receptors in the gastrointestinal circulation [PDF]

Naunyn-Schmiedeberg's Archives of Pharmacology, 1980
Evidence for the presence of specific histamine H1- and H2-receptors in the gastrointestinal circulation was obtained using histamine, 2-methylhistamine (a specific H1-agonist), 4-methylhistamine (a specific H2-agonist), and selective H1- and H2-receptor antagonists in the anesthetized dog.
Anne Sala, G. A. Charbon, H. A. A. Brouwers   +2 more
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Stimulation of cerebral histamine H2 receptors by clonidine

Nature, 1976
CLONIDINE (2-[(2,6-dichlorophenyl)amino]-2-imidazoline) is a potent antihypertensive agent whose site of action is believed to be in the central nervous system1 but its mechanism of action is far from clear. Because of its effects on peripheral tissue, it has been generally accepted that the drug stimulates alpha-adrenergic receptors1.
Y. Audigier, Alain Virion, Jean-Charles Schwartz   +2 more
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Metiamide—An orally active histamine H2-receptor antagonist [PDF]

Agents and Actions, 1973
Metiamide has been found to be about 10 times more active than burimamide in vitro in antagonizing histamine H2-receptors and nearly 5 times more active in vivo as an antagonist of histamine or pentagastrin-stimulated secretion. Effective oral ED50 doses for inhibition have been estimated as 25 μmole kg−1 against basal secretion in rats and 16 μmole kg−
John Colin Emmett, J W Black, T. Hesselbo, Charon R. Ganellin, J. H. Wyllie, Michael E. Parsons, W. A. M. Duncan   +6 more
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Histamine H2 receptor: Involvement in gastric ulceration

Life Sciences, 1976
The involvement of the H1 and H2 receptors for histamine in the pathogenesis of gastric ulcers was investigated in rats. Metiamide, an H2 receptor antagonist, reliably reduced ulceration produced by stress alone or by a combination of stress and aspirin.
Thomas H. Brown, Patricia A. Brown, Joan Vernikos-Danellis   +2 more
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Localization of histamine and histamine H2-receptor antagonists in the gastric mucosa

The Histochemical Journal, 1977
Histamine stimulates acid secretion by the parietal cell and this secretion is inhibited by the histamine H2-receptor antagonists. Whole body autoradiography showed that radioactivity from 14C-histamine was localized in the artery walls of the stomach and in the muscularis mucosae, but that the level in the fundic mucosa was the same as the blood. When
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Prolactin responses to histamine H2 receptor antagonists

Acta Endocrinologica, 1980
Abstract. We have compared the effects of cimetidine and SK&F 92994, a new more potent histamine H2 receptor antagonist, on serum prolactin, and also assessed the effect of the H2 receptor agonist impromidine on the response to cimetidine. As previously reported, cimetidine 200 mg given as an iv bolus dose produced a marked rise in serum prolactin,
P. C. Sharpe, W. L. Burland, Jane G. Mills, G. V. Groom, M. A. Melvin   +4 more
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Structural elements of H1- and H2-receptors of histamine

General Pharmacology: The Vascular System, 1980
Abstract This article sets out the proposed schemes of histamine H 1 - and H 2 -receptors. These schemes are based on the analysis of histamine agonists activity.
L.K. Gavrovskaya, V.L. Goldfarb, N.B. Brovtsyna, L.L. Grechishkin   +3 more
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