Results 141 to 150 of about 9,716 (184)

Localization of histamine and histamine H2-receptor antagonists in the gastric mucosa

The Histochemical Journal, 1977
Histamine stimulates acid secretion by the parietal cell and this secretion is inhibited by the histamine H2-receptor antagonists. Whole body autoradiography showed that radioactivity from 14C-histamine was localized in the artery walls of the stomach and in the muscularis mucosae, but that the level in the fundic mucosa was the same as the blood. When
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Analysis of the histamine H2-receptor in human monocytes

Biochemical Pharmacology, 2014
Histamine receptors are G-protein-coupled receptors (GPCRs). Canonically, the histamine H2-receptor (H2R) couples to Gs-proteins and activates adenylyl cyclases (ACs) with subsequent adenosine-3',5'-cyclic monophosphate (cAMP) generation. Recently, the classic two-state model describing GPCR activation has been extended to a multiple-state model ...
Kristin, Werner, Detlef, Neumann, Roland, Seifert   +2 more
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Histamine H1- and H2-receptors in the gastrointestinal circulation

Naunyn-Schmiedeberg's Archives of Pharmacology, 1980
Evidence for the presence of specific histamine H1- and H2-receptors in the gastrointestinal circulation was obtained using histamine, 2-methylhistamine (a specific H1-agonist), 4-methylhistamine (a specific H2-agonist), and selective H1- and H2-receptor antagonists in the anesthetized dog.
G A, Charbon, H A, Brouwers, A, Sala
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Histamine H2-receptors on single central neurones

Nature, 1975
THE detection of histamine H2-receptor antagonists1,2 has provided fresh impetus to the investigation of central effects of histamine3–7 and its possible role as a neurotransmitter3,8–10. In the hypothalamus of rat and cat microelectrophoretically applied histamine excites a large number of cells.
H L, Haas, U M, Bucher
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Histamin-H2-Receptor-Antagonismus

1978
Receptoren sind als hypothetische Orte an der Zelloberflache aufzufassen, deren Verbindung mit einem Agonisten (physiologischer Wirkstoff oder Pharmakon) von einer spezifischen Leistung der Zelle gefolgt ist. Antagonisten besitzen ebenfalls eine Affinitat zum Receptor, konnen aber die spezifische Wirkung in der Zelle nicht hervorrufen. Sie konkurrieren
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Nephrotoxicity and Hepatotoxicity of Histamine H2 Receptor Antagonists

Drug Safety, 2001
The extensive use of selective histamine H2 receptor antagonists provides a unique opportunity to describe very rare adverse drug reactions. Although mild elevation of serum creatinine level following the administration of cimetidine is relatively common, acute interstitial nephritis (AIN) is a rare hypersensitivity reaction.
A A, Fisher, D G, Le Couteur
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Conformational analyses on histamine H2-receptor antagonists

Journal of Computer-Aided Molecular Design, 1990
In a series of compounds with H2-antihistaminic activity, a conformational analysis was performed based on force field calculations. The drugs studied were cimetidine, ranitidine, famotidine, roxatidine and the conformationally more restricted ICI127032.
Hans-Dieter Höltje, Anita Batzenschlager   +1 more
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Histamine H2 receptors in rat renal glomeruli

Biochemical Pharmacology, 1982
The aim of this study was to demonstrate histamine-H2 receptors in glomeruli isolated from rat renal cortex and to correlate binding to stimulation by histamine of glomerular cyclic AMP concentration. Binding studies were performed at 10-12 degrees C using [3H]cimetidine as a tracer.
D, Chansel, J P, Oudinet, M P, Nivez, R, Ardaillou   +3 more
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Multiple Signaling Pathways of Histamine H2 Receptors

1991
Histamine H2 receptor (H2R) has been shown to be coupled to adenylate cyclase. However, we have previously demonstrated that H2R-specific stimulation also activated phospholipase C in human HL-60 promyelocytic leukemia cells (Mitsuhashi M. et al. J. Biol. Chem. 264:18356, 1989).
M, Mitsuhashi, D G, Payan
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Distribution and Classification of Airway Histamine Receptors: The Physiological Significance of Histamine H2-Receptors

1980
Publisher Summary The overall effect of histamine on the airway smooth muscle is highly complex and depends on the algebraic sum of stimulatory and inhibitory actions of a mixed population of H 1 - and H 2 -receptors, which in general act in opposite directions.
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