Results 91 to 100 of about 10,848,813 (305)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Mouse bone marrow-derived mast cells acquire responsiveness to substance P after co-culture with 3T3 fibroblasts in the presence of stem cell factor

Allergology International, 1998
Connective tissue-type mast cells degranulate in response to a neurogenic peptide, substance P, whereas bone marrow-derived mast cells (BMMC) do not respond to this stimulant when prepared with a combination of interleukin-3 and interleukin-4.
Eishin Morita, Takaaki Hiragun, Toshihiko Tanaka, Yoshikazu Kameyoshi, Tsutomu Okabe, Michihiro Hide, Shoso Yamamoto   +6 more
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Th17 Cells Express Interleukin-10 Receptor and Are Controlled by Foxp3− and Foxp3+ Regulatory CD4+ T Cells in an Interleukin-10-Dependent Manner [PDF]

Immunity, 2011
T helper 17 (Th17) cells are important for host defense against extracellular microorganisms. However, they are also implicated in autoimmune and chronic inflammatory diseases, and as such need to be tightly regulated. The mechanisms that directly control committed pathogenic Th17 cells in vivo remain unclear.
Huber S, Gagliani N, Esplugues E, O'Connor W, Huber FJ, Chaudhry A, Kamanaka M, Kobayashi Y, Booth CJ, Rudensky AY, RONCAROLO , MARIA GRAZIA, BATTAGLIA, MARCO MARIA, Flavell RA   +12 more
openaire   +2 more sources

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Development and Function of Immune Cells in an Adolescent Patient With a Deficiency in the Interleukin‐10 Receptor [PDF]

Journal of Pediatric Gastroenterology and Nutrition, 2017
ABSTRACTObjective:Monogenic defects in the interleukin‐10 (IL‐10) pathway are extremely rare and cause infantile‐onset inflammatory bowel disease (IBD)‐like pathology. Understanding how immune responses are dysregulated in monogenic IBD‐like diseases can provide valuable insight in “classical” IBD pathogenesis.
Veenbergen, Sharon, Leeuwen, Marieke, Driessen, Gertjan, Kersseboom, Rogier, Ruiter, Lilian, Raatgeep, Rolien, Kortleve, Dicky, Oosterhuis, Ytje, Biermann, Katharina, Halley, Dicky, de Ridder, Lissy, Escher, Hankje, Samsom, Janneke   +12 more
openaire   +2 more sources

Differential Expression of IFN-γ, IL-10, TLR1, and TLR2 and Their Potential Effects on Downgrading Leprosy Reaction and Erythema Nodosum Leprosum

Journal of Immunology Research, 2019
Leprosy reactions are acute immunological events that occur during the evolution of chronic infectious disease causing neural damage and disabilities.
Douglas Eulálio Antunes, Isabela Maria Bernardes Goulart, Mayara Ingrid Sousa Lima, Patrícia Terra Alves, Paula Cristina Brígido Tavares, Luiz Ricardo Goulart   +5 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Immunity, Inflammation and Heart Failure: Their Role on Cardiac Function and Iron Status

Frontiers in Immunology, 2019
Aims: Heart failure is a clinical syndrome characterized by subclinical systemic inflammation and immune system activation associated with iron deficiency.
Maria Perticone, Roberta Zito, Sofia Miceli, Angelina Pinto, Edoardo Suraci, Marta Greco, Simona Gigliotti, Marta Letizia Hribal, Salvatore Corrao, Giorgio Sesti, Francesco Perticone   +10 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source