Results 171 to 180 of about 446,676 (208)

Interleukin‐13 and interleukin‐13 receptor in Hodgkin's disease: possible autocrine mechanism and involvement in fibrosis

Histopathology, 2001
Aims: Hodgkin's disease (HD) is characterized by the presence of Hodgkin and Reed–Sternberg (H–RS) cells against a hyperplastic background of reactive cells such as lymphocytes, histiocytes, plasma cells, eosinophils, neutrophils, and stromal cells.
K, Ohshima, M, Akaiwa, R, Umeshita, J, Suzumiya, K, Izuhara, M, Kikuchi   +5 more
openaire   +2 more sources

LOCALIZATION OF HUMAN INTERLEUKIN 13 RECEPTOR IN NON-HAEMATOPOIETIC CELLS

Cytokine, 2001
Although the functional roles of interleukin (IL-)13 in haematopoietic cells are well investigated, those in non-haematopoietic cells remain to be addressed. IL-13 exerts its actions by binding to the IL-13 receptor (IL-13R) on target cells, which is composed of IL-13Ralpha1 and the IL-4 receptor alpha chain (IL-4Ralpha).
M, Akaiwa, B, Yu, R, Umeshita-Suyama, N, Terada, H, Suto, T, Koga, K, Arima, S, Matsushita, H, Saito, H, Ogawa, M, Furue, N, Hamasaki, K, Ohshima, K, Izuhara   +13 more
openaire   +2 more sources

Interleukin 13 and interleukin 13 receptor are frequently expressed by Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma

Blood, 2001
Hodgkin lymphoma (HL) is characterized by the abnormal expression of multiple cytokines, accounting for its unique clinicopathologic features. We have previously shown that interleukin-13 (IL-13) is secreted by HL cell lines and may serve as an autocrine growth factor. To determine the frequency of IL-13 expression in lymphoma patients, tissue sections
B F, Skinnider, A J, Elia, R D, Gascoyne, L H, Trümper, F, von Bonin, U, Kapp, B, Patterson, B E, Snow, T W, Mak   +8 more
openaire   +3 more sources

Interleukin-13 receptor as a unique target for anti-glioblastoma therapy

International Journal of Cancer, 2001
Surgery, radiotherapy and chemotherapy have minimally altered survival of glioblastoma patients. We explored a specific approach for glioblastoma therapy in which cellular interleukin-13 (IL-13) receptors were targeted by an IL-13 cytotoxin. A wide array of human glioblastoma cell lines expressing the receptor for IL-13 were effectively killed by an IL-
S R, Husain, B H, Joshi, R K, Puri
openaire   +2 more sources

The interleukin-4/interleukin-13 receptor of human synovial fibroblasts: overexpression of the nonsignaling interleukin-13 receptor alpha2.

Laboratory investigation; a journal of technical methods and pathology, 1998
Interleukin (IL)-4 and IL-13 are known to bind to shared heteromultimeric receptor complexes of variable composition. Given the many regulatory effects of IL-4 and IL-13 on synovial cells, we aimed to characterize their IL-4/IL-13 receptor (R). Cultivated synovial fibroblasts expressed transcripts for IL-4Ralpha and IL-13Ralpha1, the human homolog of ...
N, Feng, S M, Lugli, B, Schnyder, J F, Gauchat, P, Graber, E, Schlagenhauf, B, Schnarr, M, Wiederkehr-Adam, A, Duschl, M H, Heim, R A, Lutz, R, Moser   +11 more
openaire   +1 more source

Structural Characterization of the Human Interleukin-13 Receptor α1 Gene Promoter

Biochemical and Biophysical Research Communications, 1999
Human cancer cells have been found to express a large number of IL-13 receptors. We have previously shown that mRNA encoding one of these receptors, IL-13Ralpha1, is increased in cisplatin-resistant cells and is upregulated in tumor cells cultured with cisplatin.
T, Ise, H, Izumi, G, Nagatani, H, Takano, M, Wada, M, Kuwano, K, Kohno   +6 more
openaire   +2 more sources

Molecular targeting with recombinant cytotoxins of interleukin-13 receptor α2-expressing glioma

Journal of Neuro-oncology, 2003
A restricted receptor for interleukin 13 (IL-13R alpha2) is over-expressed in high-grade astrocytoma (HGA), but not in normal organs. In order to design and examine new anti-HGA therapies, which are molecularly directed against IL-13R alpha2, we established an IL-13R alpha2-expressing syngeneic immunocompetent murine model of HGA.
Akiva, Mintz, Denise M, Gibo, A B, Madhankumar, Waldemar, Debinski   +3 more
openaire   +2 more sources

109 Lebrikizumab Allows Interleukin-13 Membrane Binding and Subsequent Internalization through the Decoy Receptor Interleukin-13 Receptor Alpha 2

Journal of Investigative Dermatology, 2022
I. Wulur, R.D. Van Horn, A. Ryuzoji, A.J. Okragly, C. Patel, R. Benschop   +5 more
openaire   +1 more source

Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity

Cancer Cell, 2022
Yared Hailemichael, Noha Abdel-Wahab, Wai C Foo   +2 more
exaly  

Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19

New England Journal of Medicine, 2021
Anthony C Gordon, Paul Mouncey, Farah Al-Beidh   +2 more
exaly