Results 271 to 280 of about 446,523 (309)

Single Nucleotide Polymorphism of Interleukin-18 and Interleukin-18 Receptor and the Risk of Papillary Thyroid Cancer

Experimental and Clinical Endocrinology & Diabetes, 2015
Growing evidence suggests that interleukin-18 (IL-18) levels may affect neoplasia and that single nucleotide polymorphisms (SNPs) within IL-18 gene may influence its production. In this study, we evaluated whether IL-18 and IL-18 receptor (IL-18R) polymorphisms are associated with the development and clinicopathological features of papillary thyroid ...
J H, Chung, Y C, Lee, Y G, Eun, J H, Chung, S K, Kim, S, Chon, S J, Oh, S Y, Rhee, I K, Hong   +8 more
openaire   +2 more sources

Interleukin 18 Receptor 1 expression distinguishes patients with multiple sclerosis

Multiple Sclerosis Journal, 2010
Definition of dysregulated immune components in multiple sclerosis may help in the identification of new therapeutic targets. Deviation of the interleukin 18 receptor 1 (IL18R1) is of particular interest since the receptor is critical for experimental neuroinflammation.
Alan, Gillett, Melanie, Thessen Hedreul, Mohsen, Khademi, Alexander, Espinosa, Amennai D, Beyeen, Maja, Jagodic, Ingrid, Kockum, Robert A, Harris, Tomas, Olsson   +8 more
openaire   +2 more sources

Expression of Interleukin‐18 and its Receptor in Mouse Ovary

American Journal of Reproductive Immunology, 2001
PROBLEM: Interleukin‐18 (IL‐18) strongly induces interferon‐gamma production and is produced not only by types of immune cells but also by types of non‐immune cells. Ovulation is thought to be an inflammation‐like reaction in which many pro‐inflammatory cytokines are involved. We investigated whether IL‐18 is involved in the functions of ovary.
 METHOD
YOSHIYUKI TSUJI, SUSUMU ADACHI, KOJI KOYAMA, TOMOKO HASHIMOTO TAMAOKI, ATSUKO IEMOTO, JUN‐ICHI FURUYAMA, TOMOKO HASHIMOTO TAMAOKI, AKIKO HASEGAWA, JUN‐ICHI FURUYAMA, KOJI KOYAMA, TOMOKO HASHIMOTO TAMAOKI, SHIN‐ICHIRO KASHIWAMURA, HARUYASU UEDA, JUNKO MURANAKA, JUN‐ICHI FURUYAMA, HARUKI OKAMURA   +15 more
openaire   +2 more sources

Heterogeneity of response of rheumatoid synovium cell subsets to interleukin‐18 in relation to differential interleukin‐18 receptor expression

Arthritis & Rheumatism, 2003
AbstractObjectiveTo examine the differential response of rheumatoid arthritis (RA) synovium cell subsets to interleukin‐18 (IL‐18), the effect of IL‐18 on Th1‐cytokine production, and the regulation of IL‐18 by IL‐18 binding protein (IL‐18BP).MethodsRA fibroblast‐like synoviocytes were stimulated with IL‐1β, IL‐12, and IL‐18, and levels of IL‐6 were ...
Masanori, Kawashima, Pierre, Miossec
openaire   +2 more sources

Enhanced Expression of Interleukin-18 and its Receptor in Idiopathic Pulmonary Fibrosis

American Journal of Respiratory Cell and Molecular Biology, 2004
Idiopathic pulmonary fibrosis (IPF)/usual interstitial pneumonia (UIP) is a major interstitial lung disease (ILD). Recently, we established a new mouse model for ILD in which daily administration of interleukin (IL)-18 with IL-2 induces lethal lung injury, suggesting that IL-18 is involved in the pathogenesis of ILD.
Yasuhiko, Kitasato, Tomoaki, Hoshino, Masaki, Okamoto, Seiya, Kato, Yoshiro, Koda, Nobuhiko, Nagata, Masaharu, Kinoshita, Hideyuki, Koga, Do-Young, Yoon, Hironobu, Asao, Hiroshi, Ohmoto, Takeharu, Koga, Toru, Rikimaru, Hisamichi, Aizawa   +13 more
openaire   +2 more sources

Activation of the Interleukin-18 Signaling Pathway via Direct Receptor Dimerization in the Absence of Interleukin-18

Journal of Interferon & Cytokine Research
Interleukin 18 (IL-18) is a key cytokine involved in the activation of T and NK cells, which are major effector cells in tumor killing. However, recombinant IL-18 showed limited efficacy in clinical trials. A recent study showed the lack of efficacy was largely due to the existence of IL-18BP, a soluble decoy receptor for IL-18.
Yasaman Mortazavi, Robert Herrera, Matthieu Masureel, Timurs Maculins, Isabelle Lehoux, Jonathan Sockolosky, Nathan West, Beyza Bulutoglu, Yue Zhao   +8 more
openaire   +2 more sources

Evolution of interleukin-18 binding proteins and interleukin-1 receptor, type II proteins

International Journal of Molecular Medicine, 2005
Interleukin-18 (IL-18) is one of the pivotal cytokines controlling the defense mechanism called inflammation. As a first step to develop proteins for controlling the IL-18 level, we initiated a study of IL-18-binding proteins (IL-18BPs). Twenty-four IL-18BP family members, 11 from vertebrates and 13 from chordopoxviruses, were picked from the NCBI ...
Makoto, Watanabe, Naohisa, Goto, Yuko, Watanabe, Seiji, Nishiguchi, Kazunori, Shimada, Teruo, Yasunga, Hiromichi, Yamanishi   +6 more
openaire   +2 more sources

Establishment of the cells useful for murine interleukin-18 bioassay by introducing murine interleukin-18 receptor cDNA into human myelomonocytic KG-1 cells

Journal of Immunological Methods, 1998
We genetically engineered human myelomonocytic KG-I cells by introducing cDNA of murine interleukin-18 receptor (MuIL-18R) and established human cells which were capable of responding to MuIL-18. These cells expressed larger number of MuIL-18R (> 13,000 sites/cell) than intrinsic human IL-18 receptor (HuIL-18R) (< 2,500 sites/cell).
M, Taniguchi, K, Nagaoka, S, Ushio, Y, Nukada, T, Okura, T, Mori, H, Yamauchi, T, Ohta, H, Ikegami, M, Kurimoto   +9 more
openaire   +2 more sources

Expression ofinterleukin-18andinterleukin-18 receptormRNA in lung tissue samples from non small lung cancer

11.1 Lung Cancer, 2015
Interleukin-18 (IL-18) is a multifunctional cytokine that augments IFN-γ production and affects tumor immune response. No study exists investigating the expression of IL-18 and IL-18 receptor (IL-18R) mRNA in lung tissue samples of NSCLC patients. Therefore, we set out to investigate the aforementioned expressions.
Giannakopoulou, Charoula Eleni, Papadopoulou, Irene, Stratakos, Grigorios, Kaltsakas, George, Vlastos, Fotis, Trigidou, Rodoula, Koulouris, Nikolaos   +6 more
openaire   +2 more sources