Results 71 to 80 of about 5,465,732 (298)

Chitinase 3-like 1 Regulates Cellular and Tissue Responses via IL-13 Receptor α2

Cell Reports, 2013
Members of the 18 glycosyl hydrolase (GH 18) gene family have been conserved over species and time and are dysregulated in inflammatory, infectious, remodeling, and neoplastic disorders.
Chuan Hua He, Chun Geun Lee, Charles S. Dela Cruz, Chang-Min Lee, Yang Zhou, Farida Ahangari, Bing Ma, Erica L. Herzog, Stephen A. Rosenberg, Yue Li, Adel M. Nour, Chirag R. Parikh, Insa Schmidt, Yorgo Modis, Lloyd Cantley, Jack A. Elias   +15 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Molecular Mechanism of NLRP3 Inflammasome in Inflammatory Diseases and Tumors

Immunity, Inflammation and Disease
The nucleotide‐binding and oligomerization domain‐like receptors (NLRs) are pattern recognition receptors. Nucleotide‐binding oligomerization domain‐like receptor family pyrin domain‐containing 3 (NLRP3), a member of the NLRs family, can form a protein ...
Le‐Lan Gong, He‐Jiang Zhou, Quan‐Ming Zhao, Ning Xu, Feng‐Chang Huang, Ling‐Yan Su, Wen‐Liang Li   +6 more
doaj   +1 more source

Structural Basis of IL-1 Family Cytokine Signaling

Frontiers in Immunology, 2019
Interleukin-1 (IL-1) family cytokines are key signaling molecules in both the innate and adaptive immune systems, mediating inflammation in response to a wide range of stimuli.
James K. Fields, James K. Fields, James K. Fields, Sebastian Günther, Eric J. Sundberg, Eric J. Sundberg, Eric J. Sundberg   +6 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

IL-18 and VEGF-A trigger type 2 innate lymphoid cell accumulation and pro-tumoral function in chronic myeloid leukemia

Haematologica, 2023
Chronic myeloid leukemia (CML) is a hematologic malignancy associated to an unregulated growth of myeloid cells in bone marrow (BM) and peripheral blood (PB), characterized by the BCR-ABL1 translocation.
Benedetta Fiordi, Valentina Salvestrini, Gabriele Gugliotta, Fausto Castagnetti, Antonio Curti, Daniel E. Speiser, Emanuela Marcenaro, Camilla Jandus, Sara Trabanelli   +8 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Bradykinin B2 receptors of dendritic cells, acting as sensors of kinins proteolytically released by Trypanosoma cruzi, are critical for the development of protective type-1 responses [PDF]

, 2007
Although the concept that dendritic cells (DCs) recognize pathogens through the engagement of Toll-like receptors is widely accepted, we recently suggested that immature DCs might sense kinin-releasing strains of Trypanosoma cruzi through the triggering ...
Müller-Esterl Werner, Alessandra Granato, Schmitz Verônica, Scharfstein Julio, Tanowitz Herbert B, Scharfstein, Julio, Werner Müller-Esterl, Fnu Nagajyothi, de Arruda Luciana Barros, Nagajyothi, Fnu, Granato Alessandra, Pesquero João B, Müller-Esterl, Werner, Schmitz, Verônica, Luciana Barros de Arruda, Alexandre Morrot, Granato, Alessandra, Barros de Arruda, Luciana, Morrot Alexandre, Monteiro, Ana Carolina, Tanowitz, Herbert B., Julio Scharfstein, Nagajyothi Fnu, Morrot, Alexandre, Verônica Schmitz, João B Pesquero, Pesquero, João B., Monteiro Ana Carolina, Ana Carolina Monteiro, Herbert B Tanowitz   +29 more
core   +2 more sources

Natural Killer Cells: Development, Maturation, and Clinical Utilization

Frontiers in Immunology, 2018
Natural killer (NK) cells are the predominant innate lymphocyte subsets that mediate anti-tumor and anti-viral responses, and therefore possess promising clinical utilization.
Alex M. Abel, Alex M. Abel, Chao Yang, Chao Yang, Monica S. Thakar, Monica S. Thakar, Subramaniam Malarkannan, Subramaniam Malarkannan, Subramaniam Malarkannan, Subramaniam Malarkannan, Subramaniam Malarkannan   +10 more
doaj   +1 more source

The nuclear receptor LXR modulates interleukin-18 levels in macrophages through multiple mechanisms [PDF]

Scientific Reports, 2016
AbstractIL-18 is a member of the IL-1 family involved in innate immunity and inflammation. Deregulated levels of IL-18 are involved in the pathogenesis of multiple disorders including inflammatory and metabolic diseases, yet relatively little is known regarding its regulation.
Pourcet, Benoit, Gage, Matthew C., León Moreno, Theresa Elizabeth, Waddington, Kirsty E., Pello, Oscar M., Steffensen, Knut R., Castrillo, Antonio, Valledor Fernández, Annabel, Pineda-Torra, Inés   +8 more
openaire   +6 more sources