Results 181 to 190 of about 492,609 (191)
Some of the next articles are maybe not open access.
THE SOLUBLE INTERLEUKIN‐2 RECEPTOR IN HAEMATOLOGICAL DISORDERS
British Journal of Haematology, 1987Data on the clinical and biological role of sIL-"R detection in the sera of patients with a variety of hematological disorders have been provided and ...
Pizzolo G +2 more
openaire +5 more sources
The interleukin-2/interleukin-2 receptor system: structural, immunological, and clinical features
International Journal of Clinical & Laboratory Research, 1992Interleukin-2 (IL-2) has been the first and more extensively studied cytokine, in particular for its central role in the mechanisms of cell growth and differentiation. The function of IL-2 is mediated through specific receptors (IL-2R) present on the membrane of reacting cells.
SEMENZATO, GIANPIETRO CARLO +2 more
openaire +5 more sources
Regulation of interleukin-2 receptor expression and receptor release
Molecular Immunology, 1986The generation and cell surface expression of IL-2 receptors was monitored by: (i) an ELISA that permits quantitative determination of detergent-solubilized or soluble IL-2 receptors; and (ii) detection of the binding of 125I-labelled recombinant IL-2 and of anti-IL-2 receptor antibodies to receptor bearing cells.
Hisao Osawa +3 more
openaire +3 more sources
SIGNALING DOMAINS OF THE INTERLEUKIN 2 RECEPTOR
Cytokine, 2001Interleukin (IL-)2 and its receptor (IL-2R) constitute one of the most extensively studied cytokine receptor systems. IL-2 is produced primarily by activated T cells and is involved in early T cell activation as well as in maintaining homeostatic immune responses that prevent autoimmunity.
openaire +3 more sources
The bimolecular structure of the interleukin 2 receptor
Immunology Today, 1988Abstract The structure of the receptors for interleukin 2 has recently been largely resolved, being composed of noncovalently linked 55 kDa and 75 kDa polypeptides. Here, Kendall Smith discusses how the low affinity binding sites present on these molecules combine to give rise to the single high affinity site found on normal T cells.
openaire +3 more sources
Biochemical and Biophysical Research Communications, 1993
Transfectants expressing the chimeric receptor which has human interleukin-4 receptor (hIL-4R) in the extracellular domain and human interleukin-2 receptor beta chain (hIL-2R beta) in the cytoplasmic domain showed continuous growth in response to human interleukin-4 (hIL-4), whereas transfectants expressing hIL-4R responded only transiently to hIL-4 ...
A. Miyajima, K. Izuhara, Nobuyuki Harada
openaire +3 more sources
Transfectants expressing the chimeric receptor which has human interleukin-4 receptor (hIL-4R) in the extracellular domain and human interleukin-2 receptor beta chain (hIL-2R beta) in the cytoplasmic domain showed continuous growth in response to human interleukin-4 (hIL-4), whereas transfectants expressing hIL-4R responded only transiently to hIL-4 ...
A. Miyajima, K. Izuhara, Nobuyuki Harada
openaire +3 more sources
Soluble interleukin-2 receptor in cancer
Frontiers in Bioscience, 2004Levels of serum sIL-2R (soluble interleukin-2 receptor) reflect the total amount of activated T lymphocytes in tumor infiltrating lymphocytes of cancer tissues and metastatic organs, because a part of alpha-chain of IL-2R is released into the bloodstream on the attachment of IL-2 (interleukin-2) to its specific IL-2R membrane.
openaire +3 more sources
Biosensor analysis of the interleukin-2 receptor complex
Journal of Molecular Recognition, 1999Surface plasmon resonance (SPR) biosensor technology has been a significant addition to the evolution and refinement of methods to study macromolecular interactions. Prior to the advent of SPR, we employed a variety of biochemical and biological techniques to study the interleukin-2/interleukin-2 receptor system (IL-2/IL-2R). By combining site-directed
Thomas L. Ciardelli +2 more
openaire +2 more sources
American Review of Respiratory Disease, 1993
Interleukin-2 receptor (IL-2R) expression on bronchoalveolar lavage (BAL) cells was studied in patients with sarcoidosis using immune cytochemistry and cytometric analysis. A low percentage of alveolar lymphocytes (AL) was found positive for IL-2R, with 7% in patients with impaired lung function and 6% in patients with normal lung function (0.4% in ...
Ziegler-Heitbrock Hw +7 more
openaire +3 more sources
Interleukin-2 receptor (IL-2R) expression on bronchoalveolar lavage (BAL) cells was studied in patients with sarcoidosis using immune cytochemistry and cytometric analysis. A low percentage of alveolar lymphocytes (AL) was found positive for IL-2R, with 7% in patients with impaired lung function and 6% in patients with normal lung function (0.4% in ...
Ziegler-Heitbrock Hw +7 more
openaire +3 more sources
Acta Endocrinologica, 1989
Abstract. The present study was undertaken to examine the cellular control arm of the immune response with regard to T lymphocyte proliferation in euthyroid Graves' ophthalmopathy. Twenty patients with euthyroid Graves' ophthalmopathy (7 on antithyroid drugs and 13 on no treatment) and 18 healthy controls were studied in an infection-free period ...
Joseph C. K. Leung +3 more
openaire +3 more sources
Abstract. The present study was undertaken to examine the cellular control arm of the immune response with regard to T lymphocyte proliferation in euthyroid Graves' ophthalmopathy. Twenty patients with euthyroid Graves' ophthalmopathy (7 on antithyroid drugs and 13 on no treatment) and 18 healthy controls were studied in an infection-free period ...
Joseph C. K. Leung +3 more
openaire +3 more sources