Results 281 to 290 of about 465,939 (309)
Some of the next articles are maybe not open access.
Interleukin-2, Interleukin-15, and Their Receptors
International Reviews of Immunology, 1998Both IL-15 and IL-2 are 14-15 kDa members of the four alpha-helical bundle family of cytokines that have T cell growth factor activity. In contrast to the pattern manifested by IL-2, IL-15 mRNA is produced by a wide variety of tissues other than T cells. We have demonstrated that IL-15 expression is posttranscriptionally regulated by multiple elements,
Thomas A. Waldmann +2 more
openaire +3 more sources
Interleukin-2 receptors in infectious mononucleosis
Immunology Letters, 1989The majority of peripheral blood mononuclear cells (PBMC) from acute-phase infectious mononucleosis (IM) patients express high levels of T10 (CD38) and HLA-DR surface antigens, which are markers characteristic of activated T cells. However, Tac antigen (p55) expression on these cells was not detectable by flow cytometric immunofluorescence, and only a ...
J M Ryan +5 more
openaire +3 more sources
Serum Interleukin-2 and Soluble Interleukin-2 Receptor in Gestrational Trophoblastic Diseases [PDF]
Journal of the Society for Gynecologic Investigation, 1996 To investigate serum interleukin-2 (IL-2) and soluble interleukin-2 receptor (SIL-2) levels in gestational trophoblastic diseases (GTD).Sixty-six patients with GTDs and 23 first-trimester healthy pregnant women (controls) participated in this study.
Nabil A. Darwish +2 more
openaire +3 more sources
Interleukin 2/interleukin 2 receptor system in type 1 diabetes
Diabetes Research and Clinical Practice, 1989There is increasing evidence that cellular immune abnormalities are involved in the pathogenesis of type 1 diabetes mellitus. The non-obese diabetic (NOD) mouse, a model of human type 1 diabetes, develops mononuclear cell infiltration of its pancreatic islets (insulitis), leading to /3 cell destruction and overt diabetes [l]. In recent studies, most of
Koichi Yokono +4 more
openaire +3 more sources
Biotinylated recombinant interleukin-2
Journal of Immunological Methods, 1988Recombinant interleukin-2 was biotinylated using a N-hydroxyl-succinimidyl [3H]biotin ester. The biotinylated lymphokine retained full binding and growth-promoting activities when assayed on the interleukin-2-dependent murine cell line HT-2. In preliminary studies, biotinylated interleukin-2 was used in conjunction with immunogold staining to ...
Vesna Olivieri +5 more
openaire +4 more sources
Interleukin-2, anti-interleukin-2 receptor antibody, and activation of macrophages
Cellular Immunology, 1990Macrophages treated with IFN-gamma and IL-2 before exposure to parasites develop the ability to resist infection with amastigotes of Leishmania major. In this cooperative interaction of cytokines, IL-2 can be replaced with any of several mAb directed against the beta chain of the IL-2 receptor, but not by antibodies to a number of other cell receptors ...
Carol A. Nacy, Miodrag Belosevic
openaire +3 more sources
Interleukin-2 receptor expression and interleukin-2 production in bullous pemphigoid
Archives of Dermatological Research, 1990Expression of interleukin-2 (IL2) receptors was studied on peripheral blood lymphocytes (PBLs) in 25 patients with bullous pemphigoid. Analysis was carried out by flow cytometry. Without immunosuppressive therapy expression of IL2 receptors only on T cells (CD5) was significantly increased as shown by double staining (11.9% +/- 7.8% vs 2.1% +/- 1% in ...
M. Ladusch +3 more
openaire +3 more sources
The released interleukin 2 receptor binds interleukin 2 efficiently.
The Journal of Immunology, 1986Abstract The released interleukin 2 receptor (IL 2R) molecule was characterized in order to clarify its biochemical structure and to determine its functional capacity. Enzymatic digestions demonstrated that the released IL 2R, like the cell surface IL 2R, is a complex glycoprotein, modified by the addition of both N- and O-linked ...
L A, Rubin, G, Jay, D L, Nelson
openaire +2 more sources
THE SOLUBLE INTERLEUKINâ2 RECEPTOR IN HAEMATOLOGICAL DISORDERS
British Journal of Haematology, 1987Data on the clinical and biological role of sIL-"R detection in the sera of patients with a variety of hematological disorders have been provided and ...
Pizzolo G +2 more
openaire +5 more sources
The interleukin-2/interleukin-2 receptor system: structural, immunological, and clinical features
International Journal of Clinical & Laboratory Research, 1992Interleukin-2 (IL-2) has been the first and more extensively studied cytokine, in particular for its central role in the mechanisms of cell growth and differentiation. The function of IL-2 is mediated through specific receptors (IL-2R) present on the membrane of reacting cells.
SEMENZATO, GIANPIETRO CARLO +2 more
openaire +5 more sources