Results 111 to 120 of about 61,846,700 (305)

Polyene macrolide antifungal drugs trigger interleukin-1β secretion by activating the NLRP3 inflammasome. [PDF]

, 2011
The use of antimycotic drugs in fungal infections is based on the concept that they suppress fungal growth by a direct killing effect. However, amphotericin and nystatin have been reported to also trigger interleukin-1β (IL-1β) secretion in monocytes but
Rupanagudi Khader Valli, Khader Valli Rupanagudi, Allam, R., Anders Hans-Joachim, Darisipudi, M.N., Ramanjaneyulu Allam, Allam Ramanjaneyulu, Murthy Narayana Darisipudi, Hans-Joachim Anders, Rupanagudi, K.V., Rupanagudi, Khader Valli, Anders, Hans-Joachim, Anders, H.J., Darisipudi, Murthy Narayana, Darisipudi Murthy Narayana, Allam, Ramanjaneyulu   +15 more
core   +2 more sources

Dysregulated Cholesterol Metabolism, Chronic Inflammation, and Disability in Severe Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Dysregulated lipid metabolism, which can affect remyelination and neural repair, has not been extensively investigated in progressive multiple sclerosis (PMS). The goal was to examine whether dysregulated cholesterol metabolism was associated with disability in PMS. Methods The study sample comprised 53 Severe PMS patients (Expanded
Taylor R. Wicks, Mujeeb Shittu, Anna Wolska, Diala Ghazal, Bianca Weinstock‐Guttman, Alexander Burnham, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +8 more
wiley   +1 more source

Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress

Journal of Neuroinflammation, 2017
Background It has been shown that chronic stress-induced depression is associated with exaggerated inflammatory response in the brain. Alpha7 nicotinic acetylcholine receptors (α7nAChRs) regulate the cholinergic anti-inflammatory pathway, but the role of
Dan Zhao, Xulin Xu, Linna Pan, Wei Zhu, Xiaopei Fu, Lianjun Guo, Qing Lu, Jian Wang   +7 more
doaj   +1 more source

Interleukin-1 beta induces long-term increase of axonally transported opiate receptors and substance P.

, 1995
Interleukin-1 is known to exert pleiotropic effects in host defence mechanisms and in inflammation. Chronic pain, inflammation and interleukin-1 beta enhance the production of substance P.
Maloteaux, Jean-Marie, Moussaoui, S M, Laduron, P M, Jeanjean, Anne, P.M. Laduron, S.M. Moussaoui, J.-M. Maloteaux, A.P. Jeanjean   +7 more
core   +1 more source

Real‐World Safety and Effectiveness of JAK Inhibitors in Systemic Sclerosis: A Propensity‐Matched Study From the EUSTAR Cohort

Arthritis Care &Research, EarlyView.
Objective JAK inhibitors (JAKi) have shown promising effects in early‐phase studies of systemic sclerosis (SSc). We aimed to assess the safety and explore the effectiveness of JAKi compared to conventional immunosuppressants in SSc. Methods A longitudinal retrospective study of the European Scleroderma Trials and Research Group (EUSTAR) cohort was ...
Stefano Di Donato, Marie‐Elise Truchetet, Marco Minerba, Oliver Distler, Juan José Alegre Sancho, Yolanda Braun‐Moscovici, Christina Bergmann, Petros Sfikakis, Jeska K. de Vries‐Bouwstra, Murray Baron, Silvia Bellando‐Randone, Lorenzo Dagna, Christopher P. Denton, Madelon C. Vonk, Vanessa Smith, Ivan Castellvi, Gabriela Riemekasten, Andra Balanescu, Masataka Kuwana, Maria De Santis, Kamal Solanki, Anastas Batalov, Vahan Mukuchyan, Marco Matucci‐Cerinic, Yannick Allanore, Francesco Del Galdo, Michael Hughes, EUSTAR Collaborators   +27 more
wiley   +1 more source

Targeting Inflammation in Obesity and the Cardiovascular–Kidney–Metabolic (CKM) Syndrome Spectrum: A Narrative Review

Obesity Facts
Background: Cardiovascular–kidney–metabolic (CKM) syndrome refers to a multi-systemic condition with established pathophysiological connections between obesity, diabetes mellitus, chronic kidney disease (CKD), and cardiovascular disease (CVD).
Afsaneh Noormandi, Heiko Bugger, Faisal Aziz, Zvonko Milicevic, Dirk von Lewinski, Bernhard Ludvik, Verena Parzer, Andreas Zirlik, Thomas R. Pieber, Hans Peter Dimai, Harald Sourij   +10 more
doaj   +1 more source

SYNOPSIS AND PROSPECTS OF AUTOIMMUNOLOGY DEVELOPMENT WORLDWIDE (AFTER THE MATERIALS OF THE 11th INTERNATIONAL CONGRESS IN LISBON, MAY 16-20, 2018). PROCEEDING I: FIRST ACADEMY OF AUTOIMMUNITY

Медицинская иммунология, 2019
A review article is an aftermath of the 11th International Congress on Autoimmunity and First Academy of Autoimmunity, happened 14th to 20th May, 2018 in Lisbon.
E. A. Korneva, A. V. Petyaeva, T. V. Fedotkina, L. P. Churilov, Y. Shoenfeld   +4 more
doaj   +1 more source

Interleukin-21 Receptor Signalling Is Important for Innate Immune Protection against HSV-2 Infections

PLoS ONE, 2013
Interleukin (IL) -21 is produced by Natural Killer T (NKT) cells and CD4(+) T cells and is produced in response to virus infections, where IL-21 has been shown to be essential in adaptive immune responses. Cells from the innate immune system such as Natural Killer (NK) cells and macrophages are also important in immune protection against virus.
Kratholm, Sine K, Iversen, Marie B, Reinert, Line; id_orcid 0000-0002-8317-0886, Jensen, Simon K; id_orcid 0000-0002-0032-131X, Hokland, Marianne, Andersen, Thomas, Rankin, Andrew, Young, Deborah, Frische, Sebastian; id_orcid 0000-0002-0270-3602, Paludan, Søren R, Holm, Christian K   +10 more
openaire   +4 more sources

Impact of Six‐Month Monitoring Compared to Three‐Month Monitoring of Laboratories During Methotrexate Therapy

Arthritis Care &Research, EarlyView.
Objective To evaluate whether extending the American College of Rheumatology–recommended monitoring interval for complete blood count and liver function tests in patients receiving methotrexate (MTX) affects timely detection of medication‐related toxicity.
Spencer Simko, Ray Zhang, Sohini Mukherjee, Puneet Bajaj, Bonnie L. Bermas   +4 more
wiley   +1 more source

Inflammation-associated regulation of RGS in astrocytes and putative implication in neuropathic pain

Journal of Neuroinflammation, 2017
Background Regulators of G-protein signaling (RGS) are major physiological modulators of G-protein-coupled receptors (GPCR) signaling. Several GPCRs expressed in both neurons and astrocytes participate in the central control of pain processing, and the ...
Pierre J. Doyen, Maxime Vergouts, Amandine Pochet, Nathalie Desmet, Sabien van Neerven, Gary Brook, Emmanuel Hermans   +6 more
doaj   +1 more source