Results 1 to 10 of about 19,088,710 (306)

Genetic Deletion of mGlu3 Metabotropic Glutamate Receptors Amplifies Ischemic Brain Damage and Associated Neuroinflammation in Mice

Frontiers in Neurology, 2021
Backgroud: Type-3 metabotropic glutamate (mGlu3) receptors are found in both neurons and glial cells and regulate synaptic transmission, astrocyte function, and microglial reactivity.
Federica Mastroiacovo, Manuela Zinni, Giada Mascio, Valeria Bruno, Valeria Bruno, Giuseppe Battaglia, Giuseppe Battaglia, Julien Pansiot, Tiziana Imbriglio, Jerome Mairesse, Jerome Mairesse, Olivier Baud, Olivier Baud, Olivier Baud, Ferdinando Nicoletti, Ferdinando Nicoletti   +15 more
doaj   +1 more source

Molecular docking and admet properties of anacardium occidentale methanolic nut extract against inflammatory, oxidative and apoptotic markers of diabetes

Journal of Medical Science, 2023
Background. The contemporary antidiabetic drugs have side effects and adverse reactions. This demand to search for less toxic and effective treatments for diabetes from medicinal plants using computational methods.
Ajao Folasade Omobolanle, Iyedupe Marcus Olaoye, Adegbola Raphael Oneosinina, Kalejaiye Noheem Olaolu, Adelusi Temitope Isaac   +4 more
doaj   +1 more source

Evidence for Monocyte Reprogramming in a Long-Term Postsepsis Study

Critical Care Explorations, 2022
OBJECTIVES:. This study sought to identify monocyte alterations from septic patients after hospital discharge by evaluating gene expression of inflammatory mediators and monocyte polarization markers.
Raquel Bragante Gritte, PhD, Talita Souza-Siqueira, PhD, Eliane Borges da Silva, PhD, Laiane Cristina dos Santos de Oliveira, PhD, Rodrigo Cerqueira Borges, PhD, Heloísa H de Oliveira Alves, PhD, Laureane Nunes Masi, PhD, Gilson Masahiro Murata, PhD, Renata Gorjão, PhD, Adriana Cristina Levada-Pires, PhD, Antônio Carlos Nogueira, PhD, Tânia Cristina Pithon-Curi, PhD, Ricardo Bentes de Azevedo, PhD, Francisco Garcia Soriano, MD, PhD, Rui Curi, PhD, Marcel Cerqueira Cesar Machado, MD, PhD   +15 more
doaj   +1 more source

Argon preconditioning protects neuronal cells with a Toll-like receptor-mediated effect

Neural Regeneration Research, 2023
The noble gas argon has the potential to protect neuronal cells from cell death. So far, this effect has been studied in treatment after acute damage. Preconditioning using argon has not yet been investigated.
Stefanie Scheid, Adrien Lejarre, Jakob Wollborn, Hartmut Buerkle, Ulrich Goebel, Felix Ulbrich   +5 more
doaj   +1 more source

Interleukin-3 receptor in acute leukemia [PDF]

Leukemia, 2003
Recent studies indicate that abnormalities of the interleukin-3 receptor (IL-3R) are frequently observed in acute myeloid leukemias (AMLs) and may contribute to the proliferative advantage of leukemic blasts. This review analyzes the evidences indicating that the IL-3R represents one of the target molecules involved in the stimulation of proliferation ...
Testa U, Riccioni R, Diverio D, Rossini A, LO COCO, FRANCESCO, Peschle C.   +5 more
openaire   +3 more sources

Autoinflammatory disease: clinical perspectives and therapeutic strategies

Inflammation and Regeneration, 2022
The molecular platforms of the innate immune system are essential to recognize pathologic external factors that are crucial to differentiate these danger signals from host motifs.
Atsushi Kawakami, Endo Yushiro, Koga Tomohiro, Yoshiura Koh-ichiro, Migita Kiyoshi   +4 more
doaj   +1 more source

Functional reconstitution of the human interleukin-3 receptor [PDF]

Blood, 1992
The high-affinity receptors for human interleukin-3 (IL-3), GM-CSF, and IL-5 are composed of alpha and beta subunits. The alpha subunits are primary ligand binding proteins specific for each ligand, whereas the three human receptors share a common beta subunit (beta c).
T, Kitamura, A, Miyajima
openaire   +3 more sources

Interleukin Receptor Associated Kinase 1 Signaling and Its Association with Cardiovascular Diseases

Reviews in Cardiovascular Medicine, 2022
Toll-like receptors (TLRs) and interleukin-1 receptor (IL-1R) directly interact with intracellular interleukin receptor associated kinase (IRAK) family members to initialize innate immune and inflammatory responses following activation by pathogen ...
Youjing Zheng, Jia-Qiang He
doaj   +1 more source

The Role of NLR-related Protein 3 Inflammasome in Host Defense and Inflammatory Diseases [PDF]

International Neurourology Journal, 2012
Among a number of innate receptors, the nucleotide-binding domain leucine-rich repeat containing (NLR) nucleotide oligomerization domain (NOD)-like receptor families are involved in the recognition of cytosolic pathogen- or danger-associated molecules ...
Chul-Su Yang, Dong-Min Shin, Eun-Kyeong Jo   +2 more
doaj   +1 more source

Chia seeds oil ameliorate chronic immobilization stress-induced neurodisturbance in rat brains via activation of the antioxidant/anti-inflammatory/antiapoptotic signaling pathways

Scientific Reports, 2023
Chronic immobilization stress plays a key role in several neuropsychiatric disorders. This investigation assessed the possible ameliorative effect of chia seed oil (CSO) against the neurodisturbance-induced in rats by chronic immobilization.
Norhan E. Khalifa, Ahmed E. Noreldin, Asmaa F. Khafaga, Mohamed El-Beskawy, Eman Khalifa, Ali H. El-Far, Abdel-Hasseb A. Fayed, Abdeldayem Zakaria   +7 more
doaj   +1 more source