Results 251 to 260 of about 499,428 (289)

Targeting the IL-4/IL-4R Axis in Th2 Inflammatory Diseases: A Review of Clinical Efficacy and Safety. [PDF]

J Inflamm Res
Li W.
europepmc   +1 more source

Fibroblast Activation Protein Promotes Thoracic Aortic Dissection via PLAUR/ITGB1‐Mediated Pro‐inflammatory Macrophage Polarization

Advanced Science, EarlyView.
This study reveals that FAP promotes thoracic aortic dissection (TAD) through a nonenzymatic mechanism involving fibroblast‐macrophage crosstalk via the FAP/PLAUR/ITGB1/FAK axis. Targeting this pathway might offer a promising therapeutic strategy for TAD.
Hongqiao Zhu, Jianlie Wu, Ziyi Xu, Yifei Pei, Zaiping Jing, Jian Zhou, Rui Feng, Junjun Liu   +7 more
wiley   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Interleukin-22 promotes cancer stemness and chemotherapy resistance in colorectal cancer <i>via</i> epidermal growth factor receptor/extracellular signal-regulated kinase pathway. [PDF]

World J Gastrointest Oncol
Ruan HX, Fang YL, Qin XN, Lin L.
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Granulocytes and their Involvement in the Foreign Body Response to Biomaterials and Tissue Repair. [PDF]

In Vivo
Barbeck M, Jung O.
europepmc   +1 more source

Data-driven identification of core tumor-secreted factors associated with cachexia prevalence. [PDF]

Genes Dis
Cury SS, Freire PP, Carvalho RF.
europepmc   +1 more source

Effects of caffeine on neuroinflammation in anxiety and depression: a systematic review of rodent studies. [PDF]

Transl Psychiatry
da Silva Neves L, de Mattos GVRM, Oliveira-Nazareth Y, da Silva RS, Campello-Costa P.   +4 more
europepmc   +1 more source

Beyond Diabetes: The Vasculoprotective Effects and Anti-Atherosclerotic Potential of Tirzepatide. [PDF]

Int J Mol Sci
Rzepiński Ł, Tywoniuk A, Jaraczewska J, Al-Shaer A, Wiciński M.   +4 more
europepmc   +1 more source

Precision Medicine in Asthma: The Role of Biomarkers. [PDF]

Immunotargets Ther
Quek E, Horn N, Siddiqui S.
europepmc   +1 more source