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Interleukin 5 and its receptor
Progress in Growth Factor Research, 1991IL-5 is a cytokine mainly produced by T lymphocytes, especially when they are sensitized with microorganisms, which induce eosinophils and Ly-1 positive B lineage cells, both of which are probably engaged in the primary protection against micro-organisms. These possibilities are discussed by analyzing IL-5 transgenic mice.
K, Takatsu, A, Tominaga
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Recruitment pharmacophore for interleukin 5 receptor α antagonism
Peptide Science, 2006AbstractInterleukin‐5 receptor α is a therapeutic target for hypereosinophilic diseases including allergic inflammations and asthma. The cyclic peptide AF17121 (Ac‐VDE[CWRIIASHTWFC]AEE‐CONH2) has been identified as a submicromolar inhibitor of interleukin 5 (IL5)‐interleukin 5 receptor α (IL5Rα) interaction from a random peptide screen.
Madhushree, Bhattacharya +6 more
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Structure-Based Rationale for Interleukin 5 Receptor Antagonism
Current Pharmaceutical Design, 2008Human interleukin 5 (IL5) is the major hematopoietin that stimulates the proliferation, migration and activation of eosinophils and is implicated in the pathogenesis of inflammatory and other myeloproliferative diseases. IL5 functions through the signaling of a common receptor subunit beta (beta c), in a receptor activation process that requires ...
Tetsuya, Ishino +3 more
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The Biology of Interleukin-5 and Its Receptor
Cancer Investigation, 1993IL-5 is primarily a T-cell-derived cytokine that has multiple regulatory functions on eosinophils and (in the mouse) on antibody-secreting B cells. A complex network of cytokines appear to control transcription of the gene for IL-5 and its production. Abnormally high levels of this cytokine are associated with infections with tissue-dwelling parasites ...
S, Mahanty, T B, Nutman
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Cytokine Recognition by Human Interleukin 5 Receptor
2005The activation of interleukin 5 (IL-5) receptor is a dynamic process that depends on specific interaction of IL-5 with IL-5 receptor alpha, the formation of oligomeric receptor complexes with receptor beta, and the initiation of cytoplasmic phosphorylation events. These steps culminate in the triggering of a cellular response.
Tetsuya, Ishino +2 more
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