Results 221 to 230 of about 314,213 (267)

Biology of the Interleukin-2 Receptor

1998
Studies of the biology of the IL-2 receptor have played a major part in establishing several of the fundamental principles that govern our current understanding of immunology. Chief among these is the contribution made by lymphokines to regulation of the interactions among vast numbers of lymphocytes, comprising a number of functionally distinct ...
B H, Nelson, D M, Willerford
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The human interleukin-2 receptor

Journal of Cell Science, 1985
ABSTRACT Complementary DNAs corresponding to the human receptor for interleukin-2 (IL-2) have been molecularly cloned, sequenced, and expressed in both COS-1 and L cells. The human genome appears to contain a single structural gene for this receptor located on the short arm of chromosome 10 (band 14-15).
W C, Greene, J M, Depper, M, Krönke, W J, Leonard   +3 more
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INTERLEUKIN-1 RECEPTOR ANTAGONIST

Rheumatic Disease Clinics of North America, 1998
There are three members of the IL-1 gene family: IL-1 alpha, IL-1 beta, and IL-1ra, IL-1 alpha, and IL-1 beta are both antagonist molecules with many proinflammatory effects. IL-1ra is an antagonist molecule that can inhibit the effect of IL-1 alpha and IL-1 beta by specifically blocking the IL-1 receptor on target effector cells.
B, Bresnihan, G, Cunnane
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Graves' ophthalmopathy and gene polymorphisms in interleukin‐1α, interleukin‐1β, interleukin‐1 receptor and interleukin‐1 receptor antagonist

Clinical & Experimental Ophthalmology, 2009
AbstractPurpose:  Interleukin‐1 (IL‐1) is known to have an important role in pathogenesis of Graves' ophthalmopathy (GO). Polymorphisms in IL‐1 gene have been associated with autoimmune reactions. This study aimed to investigate the association of GO with single‐nucleotide polymorphisms (SNPs) in the IL‐1 family (IL‐1α, IL‐1β, IL‐1 receptor [IL‐1R] and
Omid, Khalilzadeh, Mehdi, Anvari, Alireza, Esteghamati, Mahdi, Mahmoudi, Maryam, Tahvildari, Armin, Rashidi, Farideh, Khosravi, Aliakbar, Amirzargar   +7 more
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The effects of blockade of interleukin 2 receptors and interleukin 4 receptors on cytokine production

APMIS, 1991
The understanding of the regulation of cytokine production and T‐cell proliferation by other cytokines is far from complete. We have examined the supernatant concentration of different cytokines in cultured peripheral blood lymphocytes (PBL) incubated with monoclonal antibodies against the interleukin‐2 receptor (IL‐2R) or interleukin‐4 receptor (IL‐4R)
Lai, KN, Leung, JCK, Larche, M, Ritter, MA, Li, PKT   +4 more
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Interleukin-3 and its receptor

1995
Cytokines are actively involved in the host-defense system to coordinate the functional activity and the generation of effector cells. Some of these molecules function as inflammatory mediators and hematopoietic growth factors at the same time such as IL-1, IL-6, IL-3, IL-5, and GM-CSF.
Lindemann, Albrecht, Mertelsmann, Roland
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Interleukin and Interleukin Receptor Diversity: Role of Alternative Splicing

International Reviews of Immunology, 2010
Alternative splicing is a fine-tuned process known for generating multiple functional variants from individual genes leading to protein diversity. The immune system utilizes pre-mRNA splicing to expand its gene function. Numerous immunologically relevant genes have been found to undergo alternative splicing, thus revealing a new source of complexity in
Anupama, Sahoo, Sin-Hyeog, Im
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Interleukin-1 Receptor Antagonist

1993
IL-1ra is the first described naturally occurring receptor antagonist of any cytokine or hormone-like molecule. IL-1ra is a member of the IL-1 family by three criteria: amino acid sequence homology of 26 to 30% to IL-1 beta and 19% to IL-1 alpha; similarities in gene structure; and common gene localization to human chromosome 2q14.
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Blocking interleukin-1 receptors

International Journal of Clinical & Laboratory Research, 1994
During inflammation, injury, immunological challenge or infection, interleukin-1 appears to mediate, in part, the pathogenesis, of disease. Most studies on interleukin-1 are derived from experiments in which bacterial products, such as endotoxins from Gram-negative bacteria or exotoxins from Gram-positive organisms, are used to stimulate macrophagic ...
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The interleukin-1/interleukin-1-receptor interaction

Annales de l'Institut Pasteur / Immunologie, 1987
H R, MacDonald, J W, Lowenthal
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