Saudi Pharmaceutical Journal, 2023 Trigonelline, an alkaloid found in the seeds of Trigonella foenum-graecum L. (fenugreek), has been recognized for its potential in treating various diseases.
Mohammad Faizan +7 more
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Coactivation of CB1 and GPR55 promotes GABA release and motor behavior at striatonigral terminals through increased dimerization induced by CB1 activation [PDF]
Frontiers in Molecular NeuroscienceCB1 and GPR55 receptors form heteromers in striatal neurons; however, the effects of these heteromers on GABA release at their terminals and their impact on motor behavior remain unknown. In this study, we investigate the presence of CB1-GPR55 heteromers
José Arturo Avalos-Fuentes +7 more
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Effects of ATF2/TSC1 on epilepsy by modulating the microphages polarization of microglia [PDF]
Scientific ReportsEpilepsy (EP) is a chronic nervous system disease characterized by recurrent attacks, and its causes are complicated. Inflammatory reaction mediated by microglia is an important factor in the progression of EP.
Wenjiao Huang +6 more
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Protein tyrosine kinase inhibitors modify kainic acid-induced epileptiform activity and mossy fiber sprouting but do not protect against limbic cell death [PDF]
Brazilian Journal of Medical and Biological Research, 2008 Intrahippocampal administration of kainic acid (KA) induces synaptic release of neurotrophins, mainly brain-derived neurotrophic factor, which contributes to the acute neuronal excitation produced by the toxin.
C.M. Queiroz, L.E. Mello
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Benzothiadiazines derivatives as novel allosteric modulators of kainic acid receptors. [PDF]
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2022 The majority of excitatory neurotransmission in vertebrate CNS is mediated by glutamate binding to different types of receptors. Among them, a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) and kainite receptors (KAR) are ionotropic receptors playing important pathophysiological roles. A number of small molecules acting as positive
Puja G. +6 more
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Aminooxadiazolyl kainic acid reveals that kainic acid receptors contribute to astrocytoma glutamate signaling [PDF]
, 2021 ABSTRACTThe excitatory neurotransmitter glutamate triggers a Ca2+rise and the extension of processes in astrocytes. Our results suggest that kainic acid receptors (KAR) can independently initiate glutamate signaling in astrocytoma U118-MG cells. The natural product kainic acid triggered glioexcitablity in cells and was inhibited by the KAR antagonist ...
Mitra Sadat Tabatabaee +3 more
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Molecules, 2020 This review considers the results of recent studies on marine excitatory amino acids, including kainic acid, domoic acid, dysiherbaine, and neodysiherbaine A, known as potent agonists of one of subtypes of glutamate receptors, the so-called kainate ...
Valentin A. Stonik, Inna V. Stonik
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Differential conserted activity induced regulation of Nogo receptors (1-3), LOTUS and Nogo mRNA in mouse brain. [PDF]
PLoS ONE, 2013 Nogo Receptor 1 (NgR1) mRNA is downregulated in hippocampal and cortical regions by increased neuronal activity such as a kainic acid challenge or by exposing rats to running wheels.
Tobias E Karlsson +4 more
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Glutamate may be an efferent transmitter that elicits inhibition in mouse taste buds. [PDF]
PLoS ONE, 2012 Recent studies suggest that l-glutamate may be an efferent transmitter released from axons innervating taste buds. In this report, we determined the types of ionotropic synaptic glutamate receptors present on taste cells and that underlie this postulated
Yijen A Huang, Jeff Grant, Stephen Roper
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Plants, 2022 Most excitatory impulses received by neurons are mediated by ionotropic glutamate receptors (iGluRs). These receptors are located at the apex and play an important role in memory, neuronal development, and synaptic plasticity.
Ruphi Naz +7 more
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