Results 31 to 40 of about 15,962 (236)

Dopamine acting at D1-like, D2-like and α1-adrenergic receptors differentially modulates theta and gamma oscillatory activity in primary motor cortex. [PDF]

PLoS ONE, 2017
The loss of dopamine (DA) in Parkinson's is accompanied by the emergence of exaggerated theta and beta frequency neuronal oscillatory activity in the primary motor cortex (M1) and basal ganglia.
Mazhar Özkan, Nicholas W Johnson, Umit S Sehirli, Gavin L Woodhall, Ian M Stanford   +4 more
doaj   +1 more source

Antiseizure Effects of Cannabidiol Leading to Increased Peroxisome Proliferator-Activated Receptor Gamma Levels in the Hippocampal CA3 Subfield of Epileptic Rats

Pharmaceuticals, 2022
We evaluated the effects of cannabidiol (CBD) on seizures and peroxisome proliferator-activated receptor gamma (PPARγ) levels in an animal model of temporal lobe epilepsy (TLE).
Anna-Maria Costa, Fabiana Russo, Lara Senn, Davide Ibatici, Giuseppe Cannazza, Giuseppe Biagini   +5 more
doaj   +1 more source

Nimesulide limits kainate-induced oxidative damage in the rat hippocampus [PDF]

, 2000
Kainate induces a marked expression of cyclooxygenase-2 after its systemic administration. Because cyclooxygenase-2 activity is associated to the production of reactive oxygen species, we investigated the effects of nimesulide, a selective cyclooxygenase-
Ajamieh, Hussam, Candelario-Jalil, Eduardo, Leon, Olga S., Martinez, Gregorio, Sam, Susana   +4 more
core   +1 more source

The prostaglandin EP1 receptor potentiates kainate receptor activation via a protein kinase C pathway and exacerbates status epilepticus

Neurobiology of Disease, 2014
Prostaglandin E2 (PGE2) regulates membrane excitability, synaptic transmission, plasticity, and neuronal survival. The consequences of PGE2 release following seizures has been the subject of much study.
Asheebo Rojas, Paoula Gueorguieva, Nadia Lelutiu, Yi Quan, Renee Shaw, Raymond Dingledine   +5 more
doaj   +1 more source

Potent anti-seizure effects of D-leucine

Neurobiology of Disease, 2015
There are no effective treatments for millions of patients with intractable epilepsy. High-fat ketogenic diets may provide significant clinical benefit but are challenging to implement.
Adam L. Hartman, Polan Santos, Kenneth J. O'Riordan, Carl E. Stafstrom, J. Marie Hardwick   +4 more
doaj   +1 more source

Neuroprotective Effects of Thymoquinone by the Modulation of ER Stress and Apoptotic Pathway in In Vitro Model of Excitotoxicity

Molecules, 2021
Experimental evidence indicates that the activation of ionotropic glutamate receptors plays an important role in neurological disorders’ models such as epilepsy, cerebral ischemia and trauma.
Elisa Landucci, Costanza Mazzantini, Daniela Buonvicino, Domenico E. Pellegrini-Giampietro, Maria Camilla Bergonzi   +4 more
doaj   +1 more source

Mice Lacking Functional Fas Death Receptors Are Protected from Kainic Acid-Induced Apoptosis in the Hippocampus [PDF]

, 2016
© 2014, Springer Science+Business Media New York. The Fas receptor (FasR)/Fas ligand (FasL) system plays a significant role in the process of neuronal loss in neurological disorders.
Camins, Antoni, Ettcheto, Miren, Gómez-Sintes, Raquel, Lucas, José Javier   +3 more
core   +1 more source

Decrease in the Kainate-Induced Wet Dog Shake Behavior in Genetically Epilepsy-Prone Rats: Possible Involvement of an Impaired Synaptic Transmission to the 5-HT2A Receptor

Journal of Pharmacological Sciences, 2009
.: Genetically epilepsy-prone rats (GEPR-9s) were derived from Sprague–Dawley rats (SD). The number of kainate-induced wet dog shake behavior (WDS) responses was found to decrease significantly in GEPR-9s compared to SD. WDS responses were potentiated by
Eun-Joo Shin, Ji Hoon Jeong, Yoon Hee Chung, Tae-Woo Kim, Chan Young Shin, Won-Ki Kim, Kwang-Ho Ko, Hyoung-Chun Kim   +7 more
doaj   +1 more source

Hyaluronan, neural stem cells and tissue reconstruction after acute ischemic stroke. [PDF]

, 2013
Focal stroke is a disabling disease with lifelong sensory, motor and cognitive impairments. Given the paucity of effective clinical treatments, basic scientists are developing novel options for protection of the affected brain and regeneration of lost ...
Carmichael, S Thomas, Moshayedi, Pouria
core   +1 more source

Possible Role of N-Methyl-D-Aspartate Glutamate Receptors in The Induction of Acrosome Reaction in Human Sperm [PDF]

Cell Journal
Objective: Acrosome reaction is a receptor and Ca2+-dependent process. N-Methyl-D- aspartate (NMDA) glutamatereceptors are expressed in the human sperm and are involved in the Ca2+ influx.
Hamid Reza Momeni, Elham Farjad, Abolghasem Naiemi, Tahereh Etemadi, Mohammad Hussein Abnosi, Niloufar Darbandi   +5 more
doaj   +1 more source