Results 51 to 60 of about 15,962 (236)

Gut‐microbiota‐brain Axis and post‐traumatic epilepsy

Epilepsia Open, EarlyView.
Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley   +1 more source

Enhanced expression of WD repeat-containing protein 35 (WDR35) stimulated by domoic acid in rat hippocampus: involvement of reactive oxygen species generation and p38 mitogen-activated protein kinase activation

BMC Neuroscience, 2013
Background Domoic acid (DA) is an excitatory amino acid analogue of kainic acid (KA) that acts via activation of glutamate receptors to elicit a rapid and potent excitotoxic response, resulting in neuronal cell death.
Tsunekawa Koji, Kondo Fumio, Okada Teruhiko, Feng Guo-Gang, Huang Lei, Ishikawa Naohisa, Okada Shoshiro   +6 more
doaj   +1 more source

In utero domoic acid toxicity: a fetal basis to adult disease in the California sea lion (Zalophus californianus) [PDF]

, 2008
California sea lions have been a repeated subject of investigation for early life toxicity, which has been documented to occur with increasing frequency from late February through mid-May in association with organochlorine (PCB and DDT) poisoning and ...
John Ramsdell, Tanja Zabka, Peterson, DeLong, Le Boeuf, Gilmartin, O’Shea, Le Boeuf, Lieberg-Clark, Greig, Goldstein, Scholin, Brodie, Gulland, Trainer, Gulland, Goldstein, Zabka, Lefebvre, Lefebvre, Goldberg, Hickey, Berjarano, Ramsdell, Dencker, Atkinson, Temte, Temte, Temte, Bininda-Emonds, Dobbing, Dobbing, Sacher, Watson, Clancy, Rubenstein, Finlay, Rakic, Malatesta, Dakshinamurti, Paredes, Levin, Xi, Doucette, Tryphonas, Fujita, Tremblay, Nitecka, Berger, Schreiber, Sayin, Cornejo, Doucette, Rakic, Khazipov, Bayer, Lee, Gill, Ben-Ari, Maucher, Harrison, Carter, Hardman, Belkin, Bor, Aszterbaum, Maucher, Smith, Evans, Perl, Hesp, Preston, Grieg, Feritz, Lefebvre, Buck, Busse, Schnetzer, Bernard, Khazipov, Ben-Ari, de Lanerolle, Cendes, Heindel, Tiedeken, Rodriguez, Mueller, Tiedeken   +87 more
core   +2 more sources

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Plasticity of GABA(B) receptor-mediated heterosynaptic interactions at mossy fibers after status epilepticus [PDF]

, 2003
Several neurotransmitters, including GABA acting at presynaptic GABAB receptors, modulate glutamate release at synapses between hippocampal mossy fibers and CA3 pyramidal neurons.
Bowery, N.G., Chandler, K.E., Fabian-Fine, R., Kullmann, D.M., Princivalle, A.P., Walker, M.C.   +5 more
core  

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

Epilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus, Cesar Santana‐Gomez, Ruby G. Escalante, Dominique Duncan, Pedro F. Viana, Giulia Sofia Cereda, Naoto Kuroda, Aristea S. Galanopoulou   +7 more
wiley   +1 more source

Transient changes in the limbic histaminergic system after systemic kainic acid-induced seizures

Neurobiology of Disease, 2005
Increased brain histamine is reported to protect against convulsions. We used systemic kainic acid (KA) administration to study possible changes of the histaminergic system in rat brain in status epilepticus (SE).
Minnamaija Lintunen, Tina Sallmen, Kaj Karlstedt, Pertti Panula   +3 more
doaj   +1 more source

In vivo evidence for NMDA receptor mediated excitotoxicity in a murine genetic model of Huntington Disease [PDF]

, 2008
N-methyl-D-aspartate receptor (NMDAR) mediated excitotoxicity is implicated as a proximate cause of neurodegeneration in Huntington Disease (HD). However, this hypothesis has not been tested rigorously in vivo. NMDAR NR2B-subunits are the predominant NR2
Joe Tsien, Mary Heng, Peter Detloff, Phillip Wang, Roger Albin   +4 more
core   +1 more source

Characterization of Benzodiazepine Receptor Binding in Immature Rat Brain After Kainic Acid Administration [PDF]

Epilepsia, 2000
Summary: Purpose: To evaluate the effects of status epilepticus on benzodiazepine (BDZ) receptor binding in immature rat brain. Methods: Twenty‐four immature (15 days old) and six adult (90 days old) rats were used in this study. Status epilepticus was induced in immature animals by administration of kainic acid (7 mg/kg intraperitoneal), whereas ...
L, Rocha, M E, González-Trujano, G, Jiménez, A, Gaona, R, Ondarza   +4 more
openaire   +2 more sources

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source