Frontiers in Molecular Neuroscience, 2018 Glutamate receptors play a crucial role in the central nervous system and are implicated in different brain disorders. They play a significant role in the pathogenesis of neurodegenerative diseases (NDDs) such as Alzheimer’s disease, Parkinson’s disease,
Md. Jakaria +9 more
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Altered mRNA editing and expression of ionotropic glutamate receptors after kainic acid exposure in cyclooxygenase-2 deficient mice. [PDF]
PLoS ONE, 2011 Kainic acid (KA) binds to the AMPA/KA receptors and induces seizures that result in inflammation, oxidative damage and neuronal death. We previously showed that cyclooxygenase-2 deficient (COX-2(-/-)) mice are more vulnerable to KA-induced excitotoxicity.
Luca Caracciolo +6 more
doaj +1 more source
Neuroinflammatory targets and treatments for epilepsy validated in experimental models [PDF]
, 2017 A large body of evidence that has accumulated over the past decade strongly supports the role of inflammation in the pathophysiology of human epilepsy.
Aronica, Eleonora +17 more
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Molecular Mechanism Involved in the Pathogenesis of Early-Onset Epileptic Encephalopathy [PDF]
, 2019 Recent studies have shown that neurologic inflammation may both precipitate and sustain seizures, suggesting that inflammation may be involved not only in epileptogenesis but also in determining the drug-resistant profile.
Corsello G +5 more
core +1 more source
GSK3β activity alleviates epileptogenesis and limits GluA1 phosphorylationResearch in context
EBioMedicine, 2019 Background: Glycogen synthase kinase-3β (GSK3β) is a key regulator of cellular homeostasis. In neurons, GSK3β contributes to the control of neuronal transmission and plasticity, but its role in epilepsy remains to be defined.
Malgorzata Urbanska +19 more
doaj +1 more source
Expression of prosaposin and its receptors in the rat cerebellum after kainic acid injection
IBRO Reports, 2017 Prosaposin (PSAP), a highly conserved glycoprotein, is a precursor of saposins A–D. Accumulating evidence suggests that PSAP is a neurotrophic factor that induces differentiation and prevents death in a variety of neuronal cells through the active region
Xuan Li +9 more
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Neural Regeneration Research, 2020 Hippocampal neurons undergo various forms of cell death after status epilepticus. Necrostatin-1 specifically inhibits necroptosis mediated by receptor interacting protein kinase 1 (RIP1) and RIP3 receptors. However, there are no reports of necroptosis in
Dong-Qi Lin +4 more
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Pathological Human Tau Induces Alterations in the Brain Insulin Signaling Cascade
Frontiers in Neuroscience, 2022 The process of neurodegeneration in Alzheimer’s disease has been associated with a disruption of insulin signaling cascade in neurons, and to insulin resistance. T2DM correlates with Alzheimer’s disease, but mechanisms of interaction are unknown. We have
Abdeslem El Idrissi +3 more
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The in vivo proconvulsant effects of corticotropin releasing hormone in the developing rat are independent of ionotropic glutamate receptor activation. [PDF]
, 1998 Corticotropin releasing hormone (CRH) produces age-dependent limbic seizures in the infant rat. Both the phenotype and the neuroanatomic matrix of CRH-induced seizures resemble the seizures induced by the rigid glutamate analogue, kainic acid (KA), and ...
Baram, TZ, Brunson, KL, Schultz, L
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The mGlu7 receptor provides protective effects against epileptogenesis and epileptic seizures
Neurobiology of Disease, 2019 Finding new targets to control or reduce seizure activity is essential to improve the management of epileptic patients. We hypothesized that activation of the pre-synaptic and inhibitory metabotropic glutamate receptor type 7 (mGlu7) reduces spontaneous ...
Benoit Girard +14 more
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