Neurobiology of Disease, 2022 Patients with epilepsy develop reproductive endocrine comorbidities at a rate higher than that of the general population. Clinical studies have identified disrupted luteinizing hormone (LH) release patterns in patients of both sexes, suggesting potential
Robbie J. Ingram +4 more
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Plasticity of GABA(B) receptor-mediated heterosynaptic interactions at mossy fibers after status epilepticus [PDF]
, 2003 Several neurotransmitters, including GABA acting at presynaptic GABAB receptors, modulate glutamate release at synapses between hippocampal mossy fibers and CA3 pyramidal neurons.
Bowery, N.G. +5 more
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In utero domoic acid toxicity: a fetal basis to adult disease in the California sea lion (Zalophus californianus) [PDF]
, 2008 California sea lions have been a repeated subject of investigation for early life toxicity, which has been documented to occur with increasing frequency from late February through mid-May in association with organochlorine (PCB and DDT) poisoning and ...
John Ramsdell +87 more
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BMC Neuroscience, 2013 Background Domoic acid (DA) is an excitatory amino acid analogue of kainic acid (KA) that acts via activation of glutamate receptors to elicit a rapid and potent excitotoxic response, resulting in neuronal cell death.
Tsunekawa Koji +6 more
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Kainic acid-induced seizures modulate Akt (SER473) phosphorylation in the hippocampus of dopamine D2 receptor knockout mice. [PDF]
, 2012 Dopamine D2 receptor (D2R) signalling has been shown to modulate seizure-induced hippocampal cell death. D2R knockout (D2R-/-) mice are more susceptible to kainic acid (KA)-induced excitotoxicity, displaying cell death in the CA3 subfield of the ...
Bozzi, Yuri +3 more
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In vivo evidence for NMDA receptor mediated excitotoxicity in a murine genetic model of Huntington Disease [PDF]
, 2008 N-methyl-D-aspartate receptor (NMDAR) mediated excitotoxicity is implicated as a proximate cause of neurodegeneration in Huntington Disease (HD). However, this hypothesis has not been tested rigorously in vivo. NMDAR NR2B-subunits are the predominant NR2
Joe Tsien +4 more
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Epileptogenesis in the developing brain: what can we learn from animal models? [PDF]
, 2007 Knowledge of the processes by which epilepsy is generated (epileptogenesis) is incomplete and has been a topic of major research efforts. Animal models can inform us about these processes. We focus on the distinguishing features of epileptogenesis in the
Baram, Tallie Z, Bender, Roland A
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Transient changes in the limbic histaminergic system after systemic kainic acid-induced seizures
Neurobiology of Disease, 2005 Increased brain histamine is reported to protect against convulsions. We used systemic kainic acid (KA) administration to study possible changes of the histaminergic system in rat brain in status epilepticus (SE).
Minnamaija Lintunen +3 more
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Characterization of Benzodiazepine Receptor Binding in Immature Rat Brain After Kainic Acid Administration [PDF]
Epilepsia, 2000 Summary: Purpose: To evaluate the effects of status epilepticus on benzodiazepine (BDZ) receptor binding in immature rat brain. Methods: Twenty‐four immature (15 days old) and six adult (90 days old) rats were used in this study. Status epilepticus was induced in immature animals by administration of kainic acid (7 mg/kg intraperitoneal), whereas ...
L, Rocha +4 more
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Excitotoxic degeneration of hypothalamic orexin neurons in slice culture
Neurobiology of Disease, 2004 Several lines of evidence indicate that narcolepsy, a sleep disorder, results from the loss of hypothalamic orexin (hypocretin)-containing neurons, but the mechanisms responsible for selective elimination of this neuronal population are unknown.
Hiroshi Katsuki, Akinori Akaike
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