Results 61 to 70 of about 341,836 (251)

Corticotropin‐releasing hormone–induced seizures in infant rats originate in the amygdala [PDF]

, 1992
The neuroanatomical substrate of seizures induced by picomolar amounts of corticotropin‐releasing hormone in infant rats was investigated. Electrographic and behavioral phenomena were monitored in 42 rat pups aged 5 to 22 days.
Albala, Baram, Baram, Baram, Baram, Baram, Ben-Ari, Bohmer, Cavalheiro, Cherubini, De Souza, Ehlers, Ehlers, Gilbert, Gray, Grino, Holmes, Ikonomidou-Turski, Insel, Koob, Lothman, Marrosu, Marrosu, Moshe, Oliverio, Ortolani, Palkovits, Pokorny, Sherwood, Siggins, Vale, Vale, Valentino, Watts   +33 more
core   +2 more sources

P2X receptors as targets for the treatment of status epilepticus. [PDF]

, 2013
Prolonged seizures are amongst the most common neurological emergencies. Status epilepticus is a state of continuous seizures that is life-threatening and prompt termination of status epilepticus is critical to protect the brain from permanent damage ...
Diaz-Hernandez, Miguel, Engel, Tobias, Henshall, David C, Miras-Portugal, M Teresa   +3 more
core   +1 more source

Reduced hippocampal inhibition and enhanced autism-epilepsy comorbidity in mice lacking neuropilin 2

Translational Psychiatry, 2021
The neuropilin receptors and their secreted semaphorin ligands play key roles in brain circuit development by regulating numerous crucial neuronal processes, including the maturation of synapses and migration of GABAergic interneurons.
Carol Eisenberg, Deepak Subramanian, Milad Afrasiabi, Patryk Ziobro, Jack DeLucia, Pamela R. Hirschberg, Michael W. Shiflett, Vijayalakshmi Santhakumar, Tracy S. Tran   +8 more
doaj   +1 more source

A kainic acid-induced seizure model in human pluripotent stem cell-derived cortical neurons for studying the role of IL-6 in the functional activity

Stem Cell Research, 2022
Human pluripotent stem cell (hPSC)-derived neural cultures have attracted interest for modeling epilepsy and seizure-like activity in vitro. Clinical and experimental evidence have shown that the multifunctional inflammatory cytokine interleukin (IL)-6 ...
Ropafadzo Mzezewa, Johanna Lotila, Heikki Kiiski, Andrey Vinogradov, Fikret Emre Kapucu, Jukka Peltola, Sanna Hagman, Susanna Narkilahti   +7 more
doaj   +1 more source

Mitochondria and neuroprotection in stroke: Cationic arginine-rich peptides (CARPs) as a novel class of mitochondria-targeted neuroprotective therapeutics [PDF]

, 2018
Stroke is the second leading cause of death globally and represents a major cause of devastating long-term disability. Despite sustained efforts to develop clinically effective neuroprotective therapies, presently there is no clinically available ...
Anderton, Ryan S, Knuckey, Neville W, MacDougall, Gabriella, Mastaglia, Frank L, Meloni, Bruno P   +4 more
core   +1 more source

MDMA Decreases Gluatamic Acid Decarboxylase (GAD) 67-Immunoreactive Neurons in the Hippocampus and Increases Seizure Susceptibility: Role for Glutamate [PDF]

, 2016
3,4-Methylenedioxy-methamphetamine (MDMA) is a unique psychostimulant that continues to be a popular drug of abuse. It has been well documented that MDMA reduces markers of 5-HT axon terminals in rodents, as well as humans.
Gudelsky, Gary A., Herman, James P., Huff, Courtney L., Morano, Rachel L., Yamamoto, Bryan K.   +4 more
core   +1 more source

The Effects of Kainic Acid-Induced Seizure on Gene Expression of Brain Neurotransmitter Receptors in Mice Using RT2 PCR Array

Basic and Clinical Neuroscience, 2016
Introduction: Kainic acid (KA) induces neuropathological changes in specific regions of the mouse hippocampus comparable to changes seen in patients with chronic temporal lobe epilepsy (TLE).
Taghi Naserpour Farivar, Marjan Nassiri-Asl, Pouran Johari, Reza Najafipour, Farid Hajiali   +4 more
doaj  

Oxidative Stress Plays an Important Role in Glutamatergic Excitotoxicity-Induced Cochlear Synaptopathy: Implication for Therapeutic Molecules Screening

Antioxidants
The disruption of the synaptic connection between the sensory inner hair cells (IHCs) and the auditory nerve fiber terminals of the type I spiral ganglion neurons (SGN) has been observed early in several auditory pathologies (e.g., noise-induced or ...
Anissa Rym Saidia, Florence François, François Casas, Ilana Mechaly, Stéphanie Venteo, Joseph T. Veechi, Jérôme Ruel, Jean-Luc Puel, Jing Wang   +8 more
doaj   +1 more source

Ceramide is a Mediator of Apoptosis in Retina Photoreceptors [PDF]

, 2006
PURPOSE. The precise mechanisms involved in photoreceptor apoptosis are still unclear. We here investigated the role of ceramide, a sphingolipid precursor that induces apoptosis upon cellular stress, in activating this death in photoreceptors.
Abrahan, Carolina Elizabeth, German, Olga Lorena, Miranda, Gisela Edit, Rotstein, Nora Patricia   +3 more
core   +1 more source

Differential Expression of the Metabotropic P2Y Receptor Family in the Cortex Following Status Epilepticus and Neuroprotection via P2Y1 Antagonism in Mice

Frontiers in Pharmacology, 2020
Purinergic signaling via P2 receptors is now widely accepted to play a critical role during increased states of hyperexcitability and seizure-induced pathology.
Mariana Alves, Jonathon Smith, Jonathon Smith, Tobias Engel, Tobias Engel   +4 more
doaj   +1 more source