Results 231 to 240 of about 94,971 (311)

mTOR blockade prevents progressive proteinuria but induces hyperglycaemia in obese Dahl salt‐sensitive rats before puberty

Experimental Physiology, EarlyView.
Abstract Previous studies have demonstrated that mammalian target of rapamycin (mTOR) activity is significantly increased in the kidneys of Dahl salt‐sensitive (SS) rats during the development of renal injury. Therefore, in the present study we examined whether blockade of mTOR with rapamycin inhibits renal injury in Dahl salt‐sensitive leptin receptor
Sautan Mandal, Andrea K. Brown, Ubong S. Ekperikpe, Anukool A. Bhopatkar, Krystle M. Hughes, Tyler D. Johnson, Jonita S. Cooper, Konnor T. Wilbert, Denise C. Cornelius, Jan M. Williams   +9 more
wiley   +1 more source

Exploring Autosomal Dominant Non-Syndromic Monogenic Obesity: From Genes to Therapy. [PDF]

Curr Issues Mol Biol
Luppino G, Giordano M, Franchina F, Coco R, Inì E, Fazio C, Porri D, Lugarà C, Corica D, Aversa T, Wasniewska M.   +10 more
europepmc   +1 more source

Sex‐dependent effects of a high‐fat diet‐induced obesity model on cerebrovascular health and brain metabolism

Experimental Physiology, EarlyView.
Abstract Mid‐life obesity is a major risk factor for neurodegenerative diseases, with mitochondrial and cerebrovascular dysfunction considered key mediators. Lysine acetylation is a reversible post‐translational modification that regulates several mitochondrial metabolic and biochemical processes.
Nicole N. Eminhizer, Dena Lin, Alec Hanshew, Jackson Stewart, Steven Ball, Christa Lilly, Saina S. Prabhu, Kate Karelina, Eric E. Kelley, Randy W. Bryner, Dharendra Thapa, Paul D. Chantler   +11 more
wiley   +1 more source

The role of PYY in improving insulin resistance. [PDF]

Front Endocrinol (Lausanne)
Liu C, Ren N, Zhang H, Ma J.
europepmc   +1 more source

Therapeutic potential of okra (Abelmoschus esculentus) in dysglycaemia and metabolic dysfunction: A systematic review and meta‐analysis across the diabetes spectrum

Experimental Physiology, EarlyView.
Abstract The aim of this systematic review and meta‐analysis was to evaluate comprehensively the therapeutic potential of Abelmoschus esculentus (okra) supplementation across the diabetes spectrum of key metabolic risk factors. A search was conducted in PubMed, Scopus, Web of Science, EMBASE and the Cochrane Library, up to 23 July 2025, to identify ...
Ali Jafari, Helia Mardani, Mohammad Amin Karimi, MohammadHossein Sahami Gilan, Helia Hemmat, Fatemeh Shoja, Nooshin Enayati Soofi, Ghazaleh Eslamian   +7 more
wiley   +1 more source

Genetic architecture of obesity and advances in precision pharmacotherapy: a comprehensive review. [PDF]

Acta Biochim Pol
Kavaja F, Liehr T, Temaj G.
europepmc   +1 more source

Higher body‐mass index modifies time‐resolved maternal autonomic cardiac–uterine coupling during the first stage of human labour

Experimental Physiology, EarlyView.
Abstract We investigated whether higher body mass index (BMI) modifies time‐resolved maternal autonomic control and maternal cardio‐electrohysterographic coupling (MCEC) during the first stage of labour. Seventy‐nine women were studied and, for the present analysis, grouped as Control (C; n = 41) and high BMI (HBMI; n = 38).
Carlos Gabriel Varela‐Albarrán, José Javier Reyes‐Lagos, Laura Mercedes Santiago‐Fuentes, Guadalupe Dorantes‐Méndez, Eric Alonso Abarca‐Castro, Paula Romina Soria, Araceli Espinosa‐Guerrero   +6 more
wiley   +1 more source

Is Hypothalamic Dysfunction a Cause of Type II Diabetes Mellitus?

Neuroendocrinology
Young JK.
europepmc   +1 more source

Efavirenz Interacts with Hormones Involved in Appetite and Satiety, Affecting Body Weight in Mice. [PDF]

Int J Mol Sci
Rojas-Osornio SA, Manuel-Apolinar L, Crespo-Ramírez M, Paredes-Cervantes V, Mata-Marín A, Molina-López J, Pérez de la Mora M, Borroto-Escuela D, Martínez-Lara R, Tesoro-Cruz E.   +9 more
europepmc   +1 more source

Early adversity and the comorbidity between metabolic disease and psychopathology

The Journal of Physiology, EarlyView.
Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas, Patricia Pelufo Silveira   +1 more
wiley   +1 more source