Results 31 to 40 of about 49,123 (292)

Expression of Receptors for Luteinizing Hormone-Releasing Hormone (LH-RH) in Prostate Cancers following Therapy with LH-RH Agonists

, 2010
Purpose: In addition to their expression on pituitary cells, receptors for luteinizing hormone-releasing hormone (LH-RH) are found on most prostate cancer cells.
Fazli, Laden, Pinski, Jacek, Engel, Juergen, Frank Brands, Andrew V. Schally, Jacek Pinski, Stephen V. Liu, Jie Cai, Cai, Jie, Shigang Xiong, Martin Gleave, Laden Fazli, Debra Hawes, Gleave, Martin, Schally, Andrew V, Brands, Frank, Juergen Engel, Xiong, Shigang, Susan Groshen, Liu, Stephen V, Hawes, Debra, Groshen, Susan   +21 more
core   +1 more source

Neuropeptide S-initiated sequential cascade mediated by OX1, NK1, mGlu5 and CB1 receptors: a pivotal role in stress-induced analgesia

Journal of Biomedical Science, 2020
Background Stress-induced analgesia (SIA) is an evolutionarily conserved phenomenon during stress. Neuropeptide S (NPS), orexins, substance P, glutamate and endocannabinoids are known to be involved in stress and/or SIA, however their causal links remain
Ming Tatt Lee, Yu-Ting Chiu, Yu-Chun Chiu, Chia Chun Hor, Hsin-Jung Lee, Remo Guerrini, Girolamo Calo, Lih-Chu Chiou   +7 more
doaj   +1 more source

A Splice Variant of the Human Luteinizing Hormone (LH) Receptor Modulates the Expression of Wild-Type Human LH Receptor [PDF]

Molecular Endocrinology, 2004
We previously reported a splice variant form of human LH receptor [hLHR(exon 9)] that lacks exon 9, coding the N-terminal extracellular region close to the first transmembrane domain. Several recent studies suggest that G protein-coupled receptors are able to form dimerization or oligomerization of the receptor, suggesting an intermolecular interaction
Kazuto, Nakamura, Soichi, Yamashita, Yuki, Omori, Takashi, Minegishi   +3 more
openaire   +2 more sources

Persistent cAMP signaling by internalized LH receptors in ovarian follicles

, 2016
A crucial event in female reproduction occurs at midcycle, when a LH peak induces the final maturation of ovarian follicles. LH signals via a G protein-coupled receptor selectively expressed in the outermost follicular cell layers.
Calebiro, Davide, Werthmann, Ruth C., Götz, Konrad, Sungkaworn, Titiwat, Lyga, Sandra, Volpe, Silvia, Lohse, Martin J.   +6 more
core   +1 more source

The Effect of Epigallocatechin Gallate (EGCG) to Ovary Activity and The Expression of LH Receptors in Female Rat (Rattus norvegicus) [PDF]

, 2021
Green tea polyphenol, epigallocatechin gallate (EGCG) has been proposing as a cancer chemopreventive, antioxidant and has inhibitor effect in steroidogenesis.
Desi Wulansari D, -, Widjiati, -, Sri Pantja Madyawati, -, Epy Muhammad Luqman, -, Viski Fitri Hendrawan, -, Wurlina, -   +5 more
core  

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Effects of LH-RH agonist or LH-RH immunoneutralization on pituitary and ovarian LH-RH receptors in female rats [PDF]

Reproduction, 1983
Summary. Hyperstimulation of pituitary function using daily injections of 50, 500 or 5000 ng LH-RH agonist for 3 weeks or hypostimulation by immunoneutralization of endogenous LH-RH led to disrupted oestrous cycles and profound changes in ovarian morphology.
R M, Popkin, H M, Fraser, R G, Gosden
openaire   +2 more sources

Down-regulation of pituitary receptors for luteinizing hormone-releasing hormone (LH-RH) in rats by LH-RH antagonist Cetrorelix

, 1996
Antagonists of luteinizing hormone-releasing hormone (LH-RH), unlike the LH-RH agonists, suppress gonadotropins and sex steroid secretion immediately after administration, without initial stimulatory effects.
Halmos, G, Vadillo-Buenfil, M, Pinski, J, Groot, K, Schally, A V   +4 more
core   +1 more source

Microsatellite instability, KRAS mutations and cellular distribution of TRAIL-receptors in early stage colorectal cancer. [PDF]

, 2012
Thus, we evaluated the immunofluorescence pattern of TRAIL-receptors and E-cadherin to assess the fraction of membrane-bound TRAIL-receptors in 231 selected patients with early-stage CRC undergoing surgical treatment only.
Göke, Burkhard, Thomas Kirchner (109827), Rene Jackstadt, Gallmeier, Eike, Thomas Kirchner, Gerbes, Alexander L., Kriegl, Lydia, Eike Gallmeier, Jackstadt, Rene, Alexander L Gerbes, Burkhard Göke (109829), De Toni, Enrico N., Eike Gallmeier (109823), Enrico N De Toni, Burkhard Göke, Horst, David, Andreas Jung, Rene Jackstadt (109815), David Horst, Jung, Andreas, Antonia Rizzani (109811), Heiko Hermeking (109819), Alexander L. Gerbes (109825), Kirchner, Thomas, Andreas Jung (109804), David Horst (109808), Enrico N. De Toni (109830), Lydia Kriegl, Rizzani, Antonia, Hermeking, Heiko, Heiko Hermeking, Lydia Kriegl (109801), Antonia Rizzani   +32 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source