Results 111 to 120 of about 2,265,539 (159)
Some of the next articles are maybe not open access.
Targeting of Peptide Cytotoxins to LHRH Receptors For Treatment of Cancer
Current Drug Targets, 2016Receptors for LHRH (luteinizing hormone-releasing hormone) are expressed in about 80% of human endometrial, ovarian and prostate cancers and are also found in more than 50% of breast cancers including triple negative breast cancers. In the human body, LHRH receptors are found at significant levels in the pituitary and reproductive organs.
Jörg B. Engel +5 more
openaire +4 more sources
Characterization and autoradiographic localization of LHRH receptors in the rat brain
Synapse, 1987AbstractLuteinizing hormone‐releasing hormone (LHRH) is distributed in several extrahypothalamic areas, suggesting that it might act as a neurotransmitter or neuromodulator in the central nervous system. This study was undertaken to characterize and localize LHRH receptors in the rat brain by using slide‐mounted frozen sections.
G. Pelletier, M. Badr
openaire +4 more sources
LHRH-receptors and LHRH-agonist treatment in ovarian cancer: An overview
The Journal of Steroid Biochemistry and Molecular Biology, 1990Considerable evidence exists that ovarian cancer might be gonadotrophin-dependent. Receptors for LH and FSH have been discovered in these tumors. Proliferation of ovarian cancer cells in vitro could be stimulated by gonadotrophins. Withdrawal of LH and FSH in animal models of ovarian cancer inhibited growth of these tumors.
F. Oberheuser +6 more
semanticscholar +5 more sources
BJU International, 2013
Luteinizing hormone‐releasing hormone (LHRH) agonists and antagonists are commonly used androgen deprivation therapies prescribed for patients with advanced prostate cancer (PCa). Both types of agent target the receptor for LHRH but differ in their mode of action: agonists, via pituitary LRHR receptors (LHRH‐Rs), cause an initial surge in luteinizing ...
Steven Joniau +2 more
openaire +4 more sources
Luteinizing hormone‐releasing hormone (LHRH) agonists and antagonists are commonly used androgen deprivation therapies prescribed for patients with advanced prostate cancer (PCa). Both types of agent target the receptor for LHRH but differ in their mode of action: agonists, via pituitary LRHR receptors (LHRH‐Rs), cause an initial surge in luteinizing ...
Steven Joniau +2 more
openaire +4 more sources
Neuroendocrinology, 1988
Hypophyseal and ovarian receptors for the neurohormone LHRH (LHRH-R) have been measured in young (3-4 months), middle-aged (8-11 months), constant estrous (CE, 10-14 months) and pseudopregnant (PR, 16-18 months) rats in order to study whether changes in hypothalamic and/or peripheral LHRH-like peptide production might precede and/or accompany the onset
MARCHETTI, Bianca Maria, CIONI, Matteo
openaire +5 more sources
Hypophyseal and ovarian receptors for the neurohormone LHRH (LHRH-R) have been measured in young (3-4 months), middle-aged (8-11 months), constant estrous (CE, 10-14 months) and pseudopregnant (PR, 16-18 months) rats in order to study whether changes in hypothalamic and/or peripheral LHRH-like peptide production might precede and/or accompany the onset
MARCHETTI, Bianca Maria, CIONI, Matteo
openaire +5 more sources
Absence of androgen receptors in LHRH immunoreactive neurons
Brain Research, 1993Androgen has a negative feedback effect upon reproductive functions. Studies have suggested that this effect is mediated partially at the hypothalamic level. However, it is not clear whether the action is direct or indirect on LHRH neurons. In the present study, double immunocytochemistry was used to localize LHRH and androgen receptors.
Xiaoping Huang, Richard E. Harlan
openaire +4 more sources
Journal of Urology, 2000
Agonistic analogs of luteinizing hormone-releasing hormone (LHRH) are widely used for therapy of advanced prostate cancer based upon their ability to suppress testosterone secretion in patients. Various studies also indicate that LHRH analogs might have direct inhibitory effects on prostate tumors mediated by specific LHRH receptors.
Halmos, Gábor +4 more
openaire +4 more sources
Agonistic analogs of luteinizing hormone-releasing hormone (LHRH) are widely used for therapy of advanced prostate cancer based upon their ability to suppress testosterone secretion in patients. Various studies also indicate that LHRH analogs might have direct inhibitory effects on prostate tumors mediated by specific LHRH receptors.
Halmos, Gábor +4 more
openaire +4 more sources
Neuroendocrinology, 1995
Although the role of gonadal steroids in inducing the LH surge is undisputed, the mechanism(s) whereby steroids induce the release of the hypothalamic luteinizing hormone-releasing hormone (LHRH) remain(s) enigmatic. In this study we examined the issue of the presence of steroid receptors in LHRH neurons using a mammalian species that has a true luteal
Joan C. King +8 more
openaire +4 more sources
Although the role of gonadal steroids in inducing the LH surge is undisputed, the mechanism(s) whereby steroids induce the release of the hypothalamic luteinizing hormone-releasing hormone (LHRH) remain(s) enigmatic. In this study we examined the issue of the presence of steroid receptors in LHRH neurons using a mammalian species that has a true luteal
Joan C. King +8 more
openaire +4 more sources
Modulation of hippocampal LHRH receptors by sex steroids in the rat
Peptides, 1988The modulation of brain LHRH receptors by sex steroids was assessed in the female rat hippocampus using in vitro autoradiography and iodinated [D-Ser (TBU)6, des-Gly-NH2(10)]LHRH ethylamide as the radioligand. As evaluated by optical densitometry, the density of hippocampal LHRH receptors was increased by castration.
Badr M +2 more
openaire +5 more sources
Visualization of LHRH receptors in the rat brain
European Journal of Pharmacology, 1984R. Maurer, J.C. Reubi
openaire +4 more sources