Results 141 to 150 of about 8,988 (194)

Effect of LHRH-PE40 on target cells via LHRH receptors

Journal of Drug Targeting, 2008
To detect the effect and cytotoxicity of luteinizing hormone-releasing hormone-Pseudomonas aeruginosa exotoxin 40 (LHRH-PE40) on target cells using LHRH receptors (LHRHR).The affinity of LHRH-PE40 and LHRH binding to LHRHR on the membrane surface of target cells were measured by enzyme linked immunosorbent assay.
Xin, Deng, Sven, Klussmann, Guang-Mou, Wu, Doreen, Akkerman, Ya-Qin, Zhu, Ying, Liu, Hang, Chen, Ping, Zhu, Bing-Zhi, Yu, Guo-Li, Zhang   +9 more
openaire   +2 more sources

AEZS-108: a targeted cytotoxic analog of LHRH for the treatment of cancers positive for LHRH receptors

Expert Opinion on Investigational Drugs, 2012
Receptors for the luteinizing hormone-releasing hormone [LHRH, also known as gonadotropin-releasing hormone (GnRH)] can be regarded as an ideal target for a personalized medicine approach in cancer therapy. LHRH receptors are expressed in about 80% of human endometrial and ovarian cancers, 86% of prostate cancer, and about 50% of breast cancers ...
Andrew V Schally
exaly   +4 more sources

LHRH RECEPTORS AND LHRH RECEPTOR-BEARING CELLS IN PITUITARIES OF STREPTOZOCIN DIABETIC MALE RATS

Pharmacological Research, 1997
Streptozocin (STZ)-diabetic rats have low hypothalamic luteotropic hormone-releasing hormone (LHRH) secretion and various alterations of gonadotrope cells, among which low luteotropic hormone (LH) secretion. Possible causes for the gonadotrope disorders may be low hypothalamic LHRH secretion alone or combined with reduced (a) number of LHRH receptor ...
G E, Bestetti, D, Barone, A, Walz, B, Moser, C E, Boujon, A, Brändli-Baiocco, G L, Rossi   +6 more
openaire   +2 more sources

Absence of androgen receptors in LHRH immunoreactive neurons

Brain Research, 1993
Androgen has a negative feedback effect upon reproductive functions. Studies have suggested that this effect is mediated partially at the hypothalamic level. However, it is not clear whether the action is direct or indirect on LHRH neurons. In the present study, double immunocytochemistry was used to localize LHRH and androgen receptors.
X, Huang, R E, Harlan
openaire   +2 more sources

HIGH INCIDENCE OF RECEPTORS FOR LUTEINIZING HORMONE-RELEASING HORMONE (LHRH) AND LHRH RECEPTOR GENE EXPRESSION IN HUMAN PROSTATE CANCERS

Journal of Urology, 2000
Agonistic analogs of luteinizing hormone-releasing hormone (LHRH) are widely used for therapy of advanced prostate cancer based upon their ability to suppress testosterone secretion in patients. Various studies also indicate that LHRH analogs might have direct inhibitory effects on prostate tumors mediated by specific LHRH receptors.
G, Halmos, J M, Arencibia, A V, Schally, R, Davis, D G, Bostwick   +4 more
openaire   +2 more sources

LHRH Receptor Targeted Therapy for Breast Cancer

2008
Breast cancer remains the most common cancer among women, with an estimated 212,920 new cases and 40,970 deaths in the United States in 2006. The present work extends the studies of nanoparticles targeted to the luteinizing hormone-releasing hormone (LHRH) receptor which is overexpressed in breast, ovarian, endometrial and prostate cancer cells.
S S, Kakar, H, Jin, B, Hong, J W, Eaton, Kyung A, Kang   +4 more
openaire   +2 more sources

Inhibin Interaction with LHRH Receptors at the Pituitary Level

Archives of Andrology, 1982
In order to investigate whether inhibin could modulate the action of luteinizing hormone releasing hormone (LHRH), the in vitro effect of inhibin of LHRH bindings to the pituitaries from intact adult male rats was studied. The inhibin preparations suppressed the binding of labeled LHRH to pituitary receptors in a dose-related manner.
P R, Sheth, S P, Dandekar, N, Seethalakshmi, A R, Sheth   +3 more
openaire   +2 more sources

Receptor-mediated internalization of LHRH antagonists by pituitary cells

Molecular and Cellular Endocrinology, 1983
A fluorescently labeled antagonist of luteinizing hormone releasing hormone (LHRH), D-pGlu-D-Phe-D-Trp-Ser-Tyr-D-Lys6-(tetramethylrhodamine)-Leu-Arg-Pro-Gly-NH2, was prepared. This peptide retained high-affinity binding to the LHRH receptor of pituitary plasma membrane preparations.
E, Hazum, R, Meidan, M, Liscovitch, D, Keinan, H R, Lindner, Y, Koch   +5 more
openaire   +2 more sources

Variations in the number of pituitary LHRH receptors correlated with altered responsiveness to LHRH

Life Sciences, 1982
Isolated pituitary cells from metestrous, ovariectomized (OVX), and ovariectomized-estradiol treated (OVX-EB) rats were employed to study the gonadotrophin response to luteinizing hormone-releasing hormone (LHRH) challenge and to quantitate LHRH receptors, using a labeled LHRH analog.
R, Meidan, N B, Aroya, Y, Koch
openaire   +2 more sources

Abstract 5476: LHRH receptor targeting as mechanism of anti-tumor activity for cytotoxic conjugates of Disorazol Z with the LHRH receptor agonistic peptide D-Lys6-LHRH.

Cancer Research, 2013
Abstract Background For drug-targeting aimed at the treatment of LHRH receptor overexpressing cancers the LHRH receptor agonistic peptide D-Lys6-LHRH has been conjugated to the novel highly cytotoxic natural compound Disorazol Z.
Babette Aicher, Tilmann Schuster, Lars Blumenstein, Antje Schubert, Carsten Gründker, Joerg B. Engel, Olaf Ortmann, Rolf Mueller, Eckhard Guenther, Matthias Gerlach, Michael Teifel   +10 more
openaire   +1 more source