Results 151 to 160 of about 8,865 (194)

Opposite Changes of Pituitary and Ovarian Receptors for LHRH in Ageing Rats: Further Evidence for a Direct Neural Control of Ovarian LHRH Receptor Activity

Neuroendocrinology, 1988
Hypophyseal and ovarian receptors for the neurohormone LHRH (LHRH-R) have been measured in young (3-4 months), middle-aged (8-11 months), constant estrous (CE, 10-14 months) and pseudopregnant (PR, 16-18 months) rats in order to study whether changes in hypothalamic and/or peripheral LHRH-like peptide production might precede and/or accompany the onset
MARCHETTI, Bianca Maria, CIONI, Matteo
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Abstract 5476: LHRH receptor targeting as mechanism of anti-tumor activity for cytotoxic conjugates of Disorazol Z with the LHRH receptor agonistic peptide D-Lys6-LHRH.

Cancer Research, 2013
Abstract Background For drug-targeting aimed at the treatment of LHRH receptor overexpressing cancers the LHRH receptor agonistic peptide D-Lys6-LHRH has been conjugated to the novel highly cytotoxic natural compound Disorazol Z.
Babette Aicher, Tilmann Schuster, Lars Blumenstein, Antje Schubert, Carsten Gründker, Joerg B. Engel, Olaf Ortmann, Rolf Mueller, Eckhard Guenther, Matthias Gerlach, Michael Teifel   +10 more
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The prolonged action of the LHRH agonist buserelin (HOE 766) may be due to prolonged binding to the LHRH receptor

Life Sciences, 1986
Hemi-pituitary glands of ovariectomized rats were superfused for 4 h with either LHRH or the analog buserelin (HOE 766) at several concentrations, and thereafter with medium only for another 1.5 h. In a further experiment glands were exposed for 2.5 h to LHRH or buserelin at a single concentration (5 ng/ml) and subsequently for another 2.5 h to either ...
Koiter, T. R., Denef, C., Andries, M., Moes, H., Schuiling, G. A.   +4 more
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Solubilization of a large molecular weight form of the rat LHRH receptor

Journal of Endocrinology, 1987
ABSTRACT The LHRH receptor has been solubilized from male rat anterior pituitary glands, using the zwitterionic detergent 3-((3-cholamidopropyl)-dimethylammonio)-1-propanesulphonate in the presence of a high concentration of sodium chloride. This method gave high yields (up to > 70%) of the LHRH-binding site from the membrane preparation ...
S A, Ogier, R, Mitchell, G, Fink
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Peripubertal Decline in Ovarian LHRH Receptor Content: Characterization and Distribution

Neuroendocrinology, 1983
In the rat, ovarian LHRH receptor content, as measured by the binding of 125I-D-Ala6, Pro9-LHRH (A-LHRH) to ovarian membranes, decreases markedly during the days preceding the first preovulatory gonadotropin surge. The present study shows that the decrease in LHRH receptor number occurs exclusively in granulosa cells, and that the greatest rate of ...
S S, White, S R, Ojeda
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A Subgroup of LHRH Neurons in Guinea Pigs with Progestin Receptors Is Centrally Positioned within the Total Population of LHRH Neurons

Neuroendocrinology, 1995
Although the role of gonadal steroids in inducing the LH surge is undisputed, the mechanism(s) whereby steroids induce the release of the hypothalamic luteinizing hormone-releasing hormone (LHRH) remain(s) enigmatic. In this study we examined the issue of the presence of steroid receptors in LHRH neurons using a mammalian species that has a true luteal
J C, King, D W, Tai, I K, Hanna, A, Pfeiffer, P, Haas, P M, Ronsheim, S C, Mitchell, J C, Turcotte, J D, Blaustein   +8 more
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Ovarian LHRH Receptors Increase following Lesions of the Major LHRH Structures in the Rat Brain: Involvement of a Direct Neural Pathway

Neuroendocrinology, 1985
Specific lesions of different brain structures known to contain or to be coursed by LHRH neurons have been carried out in intact cycling female rats in order to investigate the role played by central LHRH and neuronal systems in the regulation of ovarian and hypophyseal LHRH receptor (LHRH-R) levels, using the stable LHRH analog [D-Ser (TBU)6] Des ...
MARCHETTI, Bianca Maria, CIONI, Matteo, SCAPAGNINI U.   +2 more
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Preparation and use of biotinylated ligands for LHRH receptor purification

Tetrahedron Letters, 1989
Abstract The synthesis of biotinylated analogues of LHRH is described in which the peptides simultaneously combine biotin and either a photolabile or an amino substituent. In rat anterior pituitary membranes the conjugate [biotinyl-aminoethylglycyl-D-Lys 6 , des Gly 10 ]-LHRH ethylamide showed approximately 50% specific binding and could be ...
Christine M. Bladon, Rory Mitchell, Sally-Ann Ogier   +2 more
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Pharmacological regulation of pituitary LHRH receptors

1984
The tonic and pulsatile release of pituitary gonadotropic hormones is regulated by LHRH (Fink, 1976). In physiological circumstances, the secretion of LHRH is pulsatile rather than continuous. There is increasing evidence that modulation of pulse frequency, rather than the pulse amplitude, plays a critical role in the regulation of gonadotropin ...
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The regulation of LHRH action at the pituitary and gonadal receptor level: A review

Psychoneuroendocrinology, 1983
Luteinizing hormone releasing-hormone (LHRH) and its highly active agonists are under clinical investigation for the control of reproductive function and for suppression of hormone dependent tumours. The regulation of LHRH action by pituitary receptors and expression of the biological LHRH effect by gonadotropin release and activation of steroid ...
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