Results 151 to 160 of about 8,988 (194)

Allopregnanolone induces LHRH and glutamate release through NMDA receptor modulation

Endocrine, 2011
LHRH release from hypothalamus is influenced by the neurotransmitter glutamate that acts, among others, on NMDA receptors present in LHRH neurons. On the other hand, the neurosteroid allopregnanolone can modulate the activity of specific neurotransmitter receptors and affect neurotransmitter release. We examined the role of allopregnanolone on in vitro
Fernando A, Giuliani, Roberto, Yunes, Claudia E, Mohn, Myriam, Laconi, Valeria, Rettori, Ricardo, Cabrera   +5 more
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Peripubertal Decline in Ovarian LHRH Receptor Content: Characterization and Distribution

Neuroendocrinology, 1983
In the rat, ovarian LHRH receptor content, as measured by the binding of 125I-D-Ala6, Pro9-LHRH (A-LHRH) to ovarian membranes, decreases markedly during the days preceding the first preovulatory gonadotropin surge. The present study shows that the decrease in LHRH receptor number occurs exclusively in granulosa cells, and that the greatest rate of ...
S S, White, S R, Ojeda
openaire   +2 more sources

LHRH receptor expression in sarcomas of bone and soft tissue

Hormone Molecular Biology and Clinical Investigation, 2016
Abstract Aim: Luteinizing hormone releasing hormone (LHRH) is a neurohormone, secreted by the hypothalamus, which regulates the secretion of gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the pituitary.
Chenthuran, Deivaraju, H Thomas, Temple, Norman, Block, Philip, Robinson, Andrew V, Schally   +4 more
openaire   +2 more sources

LHRH-receptor-regulated Ca2+-ATPase activity in murine pituitary gland

Neurochemical Research, 1987
Addition of luteinizing hormone releasing hormone (LHRH) in vitro (10(-5) -5 X 10(-9) M) to murine pituitary membranes resulted in a dose-related decrease in Ca2+-ATPase activity within 15 min. Inhibitory effects of LHRH (10(-7) M) occurred after 90 sec, and appeared maximal by 120 sec.
S L, Dalterio, C R, Esquivel, S A, Bernard   +2 more
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Opposite Changes of Pituitary and Ovarian Receptors for LHRH in Ageing Rats: Further Evidence for a Direct Neural Control of Ovarian LHRH Receptor Activity

Neuroendocrinology, 1988
Hypophyseal and ovarian receptors for the neurohormone LHRH (LHRH-R) have been measured in young (3-4 months), middle-aged (8-11 months), constant estrous (CE, 10-14 months) and pseudopregnant (PR, 16-18 months) rats in order to study whether changes in hypothalamic and/or peripheral LHRH-like peptide production might precede and/or accompany the onset
MARCHETTI, Bianca Maria, CIONI, Matteo
openaire   +3 more sources

Modulation of hippocampal LHRH receptors by sex steroids in the rat

Peptides, 1988
The modulation of brain LHRH receptors by sex steroids was assessed in the female rat hippocampus using in vitro autoradiography and iodinated [D-Ser (TBU)6, des-Gly-NH2(10)]LHRH ethylamide as the radioligand. As evaluated by optical densitometry, the density of hippocampal LHRH receptors was increased by castration.
Badr M, MARCHETTI, Bianca Maria, Pelletier G.   +2 more
openaire   +3 more sources

Characterization and autoradiographic localization of LHRH receptors in the rat brain

Synapse, 1987
AbstractLuteinizing hormone‐releasing hormone (LHRH) is distributed in several extrahypothalamic areas, suggesting that it might act as a neurotransmitter or neuromodulator in the central nervous system. This study was undertaken to characterize and localize LHRH receptors in the rat brain by using slide‐mounted frozen sections.
M, Badr, G, Pelletier
openaire   +2 more sources

Targeting of Peptide Cytotoxins to LHRH Receptors For Treatment of Cancer

Current Drug Targets, 2016
Receptors for LHRH (luteinizing hormone-releasing hormone) are expressed in about 80% of human endometrial, ovarian and prostate cancers and are also found in more than 50% of breast cancers including triple negative breast cancers. In the human body, LHRH receptors are found at significant levels in the pituitary and reproductive organs.
Jorg B, Engel, Hans-Rudolf, Tinneberg, Ferenc G, Rick, Enniko, Berkes, Andrew V, Schally   +4 more
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Effects of an LHRH agonist and gonadotropins on testicular prolactin receptors

Peptides, 1982
Effects of administration of the LHRH agonist D-Leu6-LHRH ethylamide (LHRH-A), gonadotropin (PMS), and their interaction on testicular prolactin (PRL) receptor levels were investigated in rats. LHRH-A (2 micrograms/100 g body wt.) or saline was injected SC daily, and PMS (5 IU) injected every other day.
J B, Fishback, A, Arimura, C M, Turkelson   +2 more
openaire   +2 more sources

Intracellular receptors mediate gonadal steroid modulation of LHRH-induced LH release

Molecular and Cellular Endocrinology, 1982
Primary cultures of enzymatically dispersed rat pituitary cells were used to study the role of intracellular receptors in gonadal steroid modulation of LHRH-induced LH release. Nuclear receptors for both testosterone (T) and 17 beta-estradiol (E) were observed, with KD values of 6.3 and 0.1 nM respectively.
F, Kamel, L C, Krey
openaire   +2 more sources