Results 281 to 290 of about 2,728,981 (353)
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Localization of melatonin and its receptors (melatonin 1a and 1b receptors) in the mouse inner ear
Acta Oto-Laryngologica, 2019Background: In the inner ear, evidence has been gathered indicating that melatonin plays important roles in inner ear physiology and pathophysiology. However, no attempt has been made previously to investigate the localization or expression of melatonin ...
M. Takumida, M. Anniko
semanticscholar +1 more source
Sleep well. Untangling the role of melatonin MT1 and MT2 receptors in sleep
Journal of Pineal Research, 2019The pharmacological potential of targeting selectively melatonin MT1 or MT2 receptors has not yet been exploited in medicine. Research using selective MT1/MT2 receptor ligands and MT1/MT2 receptor knockout mice has indicated that the activation of MT2 ...
G. Gobbi, S. Comai
semanticscholar +1 more source
Biochemistry (Moscow), 2001
Current opinions on the potential role of orphan nuclear retinoid receptors of the ROR/RZR subfamily in regulatory activities of the pineal gland hormone melatonin are reviewed. The mechanisms of receptor--DNA interactions and known coactivators, tissue peculiarities of the expression of different receptor isoforms, and its regulation are described ...
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Current opinions on the potential role of orphan nuclear retinoid receptors of the ROR/RZR subfamily in regulatory activities of the pineal gland hormone melatonin are reviewed. The mechanisms of receptor--DNA interactions and known coactivators, tissue peculiarities of the expression of different receptor isoforms, and its regulation are described ...
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Journal of Neural Transmission, 1988
The pineal gland and its major product melatonin have a key role in conveying the environmental photoperiodic stimuli that impinge upon the mammalian reproductive axis. The brain, especially the medial preoptic and suprachiasmatic areas are thought to be the main sites of melatonin's neuroendocrine activity.
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The pineal gland and its major product melatonin have a key role in conveying the environmental photoperiodic stimuli that impinge upon the mammalian reproductive axis. The brain, especially the medial preoptic and suprachiasmatic areas are thought to be the main sites of melatonin's neuroendocrine activity.
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Functionality of Melatonin Receptors: Internalization
2022The main step of classical desensitization of a receptor, by mean of its disappearance from the plasma membrane, is its internalization. This is a key factor in the regulation of agonist-mediated signaling pathways, as it most of the time stops the activation of the receptor. Internalization is thus important to evaluate, as a complementary information
Clémence, Dupré +2 more
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Melatonin receptors and ligands
2000The goal of the article is to provide a clearer understanding of how melatonin and its related analogs interact with melatonin receptors with the hope of developing important tools and agents of significant clinical and scientific importance. The review provides a compilation of the currently published melatonergic ligands and their relative affinities
P A, Witt-Enderby, P K, Li
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Alternative Ligands at Melatonin Receptors
2022Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that possesses a wide range of biological effects. Most of the main recognized effects of this hormone in mammals are due to its interaction with two G protein-coupled receptors, MT1 and MT2. Ligand-binding studies have been based on the use of its radioligand analog, 2[125I]-iodomelatonin, a ...
Legros, Céline +2 more
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Investigational melatonin receptor agonists
Expert Opinion on Investigational Drugs, 2010Melatonin is a major chronobiological regulator involved in circadian phasing, sleep, and numerous other functions including cyto-/neuroprotection, immune modulation, and energy metabolism. The suitability of melatonin as a drug is limited because of its short half-life.
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Expert Opinion on Therapeutic Patents, 1999
The hormone melatonin is released following a circardian rhythm with highest levels during the subjective night. It regulates a variety of physiological and neuroendocrine functions through activation of G-protein-coupled membrane receptors in target tissues.
Dieter Steinhilber, Carsten Carlberg
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The hormone melatonin is released following a circardian rhythm with highest levels during the subjective night. It regulates a variety of physiological and neuroendocrine functions through activation of G-protein-coupled membrane receptors in target tissues.
Dieter Steinhilber, Carsten Carlberg
openaire +1 more source