Results 31 to 40 of about 23,013 (268)

Melatonin Signaling Controls the Daily Rhythm in Blood Glucose Levels Independent of Peripheral Clocks. [PDF]

PLoS ONE, 2016
Melatonin is rhythmically secreted by both the pineal gland and retina in a circadian fashion, with its peak synthesis occurring during the night. Once synthesized, melatonin exerts its effects by binding to two specific G-protein coupled receptors ...
Sharon Owino, Susana Contreras-Alcantara, Kenkichi Baba, Gianluca Tosini   +3 more
doaj   +1 more source

Seasonal Variation of Melatonin Concentration and mRNA Expression of Melatonin-Related Genes in Developing Ovarian Follicles of Mares Kept under Natural Photoperiods in the Southern Hemisphere

Animals, 2023
This study investigated the seasonal variations in mRNA expression of FSH (Fshr), LH (Lhr) receptors, melatonin (Mt1 and Mt2) receptors, melatonin-synthetizing enzymes (Asmt and Aanat) and melatonin concentration in developing follicles from mares raised
Lia Alencar Coelho, Luciano Andrade Silva, Ana Paula Reway, Daniella Do Carmo Buonfiglio, Jéssica Andrade-Silva, Patrícia Rodrigues Lourenço Gomes, José Cipolla-Neto   +6 more
doaj   +1 more source

Characterization of central melatonin receptors using ¹²⁵I‐melatonin [PDF]

FEBS Letters, 1986
The binding of 125I‐melatonin, a potent analog of melatonin, to rat brain synaptosomal preparations was investigated. 125I‐melatonin bound with high affinity (K d = 38 nM) to a single class of sites (B max = 81 protein). Kinetic studies indicated that binding was time‐dependent and reversible. Specific 125I‐melatonin binding was inhibited by melatonin,
Laudon, Moshe, Zisapel, Nava
openaire   +2 more sources

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Circadian Rhythm Regulates Development of Enamel in Mouse Mandibular First Molar. [PDF]

PLoS ONE, 2016
Rhythmic incremental growth lines and the presence of melatonin receptors were discovered in tooth enamel, suggesting possible role of circadian rhythm.
Jiang Tao, Yue Zhai, Hyun Park, Junli Han, Jianhui Dong, Ming Xie, Ting Gu, Keidren Lewi, Fang Ji, William Jia   +9 more
doaj   +1 more source

Plant‐Derived Melatonin Inhibits Bacterial Virulence via CpxA/R Two‐Component System

Advanced Science, EarlyView.
Plant‐derived melatonin is sensed by CpxAE48/T51, which inhibits the phosphorylation cascade transmission from CpxAH240 to CpxRD52, resulting in the inhibition of DNA‐binding capacity of CpxR and subsequent T3SS genes expression in Pst DC3000. ABSTRACT In defending against pathogens, plants deploy diverse secondary metabolites and signaling molecules ...
Jin‐Wei Wei, Wei Liu, Bili Cao, Dan Zhao, Chengqiang Wang, Xin Hou, Tangyuan Ning, Biao Gong   +7 more
wiley   +1 more source

Melatonin Modulates the GABAergic Response in Cultured Rat Hippocampal Neurons

Journal of Pharmacological Sciences, 2012
In the present study, we investigated the effect of melatonin on the GABA-induced current (IGABA) and GABAergic miniature inhibitory postsynaptic currents (mIPSCs) in cultured rat hippocampal neurons using the whole-cell patch-clamp technique.
Xin-Ping Cheng, Hao Sun, Zeng-You Ye, Jiang-Ning Zhou   +3 more
doaj   +1 more source

Adverse Childhood Experiences in Autistic and Neurotypical Girls

Autism Research, EarlyView.
ABSTRACT Adverse childhood experiences (ACEs) are potentially traumatic, life‐altering events that occur in childhood with long‐term negative physical and/or mental health outcomes. Previous research, while limited and largely focused on males, suggests children with autism spectrum disorder (ASD) are at higher risk of experiencing ACEs than typically ...
Jon Ebert, Rachael A. Muscatello, Trey McGonigle, Simon Vandekar, Blythe A. Corbett   +4 more
wiley   +1 more source

Pharmacological modulation of MRAP2 protein on murine melatonin receptor signaling

Frontiers in Endocrinology
IntroductionMTNR1A and MTNR1B, crucial for regulating circadian rhythms and various physiological processes, have well- established biological significance.
Wenqi Song, Yanchuan Li, Hongtao Xu, Yaqun Zhang, Liu Liu, Yihao Li, Xinran Wang, Yueming Du, Yining Chen, Jianjun Lyu, Lingjing Jin, Chao Zhang, Yuchen Xiao   +12 more
doaj   +1 more source

Pineal and cortical melatonin receptors MT1 and MT2 are decreased in Alzheimer’s disease

European Journal of Histochemistry, 2009
The pineal hormone melatonin is involved in physiological transduction of temporal information from the light dark cycle to circadian and seasonal behavioural rhythms, as well as possessing neuroprotective properties.
P Brunner, N Sözer-Topcular, R Jockers, R Ravid, D Angeloni, F Fraschini   +5 more
doaj   +1 more source