Melatonin Receptors: A Key Mediator in Animal Reproduction [PDF]
Veterinary Sciences, 2022 Melatonin, a hormone produced by the mammalian pineal gland, influences various physiological activities, many of which are related to animal reproduction, including neuroendocrine function, rhythm regulation, seasonal behavior, gonadogenesis, gamete ...
Yuan Gao +3 more
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Structural insights into melatonin receptors. [PDF]
FEBS J, 2020 The long‐anticipated high‐resolution structures of the human melatonin G protein‐coupled receptors MT1 and MT2, involved in establishing and maintaining circadian rhythm, were obtained in complex with two melatonin analogs and two approved anti‐insomnia ...
Stauch B, Johansson LC, Cherezov V.
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Structural basis of the ligand binding and signaling mechanism of melatonin receptors. [PDF]
Nat Commun, 2022 Melatonin receptors (MT 1 and MT 2 in humans) are family A G protein–coupled receptors that respond to the neurohormone melatonin to regulate circadian rhythm and sleep.
Wang Q +8 more
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Membrane Melatonin Receptors Activated Cell Signaling in Physiology and Disease. [PDF]
Int J Mol Sci, 2021 The pineal hormone melatonin has attracted great scientific interest since its discovery in 1958. Despite the enormous number of basic and clinical studies the exact role of melatonin in respect to human physiology remains elusive.
Nikolaev G, Robeva R, Konakchieva R.
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Melatonin receptors and Per1 expression in the inferior olivary nucleus of the Sapajus apella monkey [PDF]
Frontiers in Neuroscience, 2022 Melatonin is a transducer of photic environmental information and participates in the synchronization of various physiological and behavioral phenomena.
Marcos Donizete Junior Granado +9 more
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Modeling the Heterodimer Interfaces of Melatonin Receptors [PDF]
Frontiers in Cellular Neuroscience, 2021 Melatonin receptors are Class A G protein-coupled receptors (GPCRs) that regulate a plethora of physiological activities in response to the rhythmic secretion of melatonin from the pineal gland.
Lap Hang Tse +3 more
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The genomic response of human granulosa cells (KGN) to melatonin and specific agonists/antagonists to the melatonin receptors [PDF]
Scientific Reports, 2022 Melatonin is a known modulator of follicle development; it acts through several molecular cascades via binding to its two specific receptors MT1 and MT2. Even though it is believed that melatonin can modulate granulosa cell (GC) functions, there is still
Asma Arjoune, Marc-André Sirard
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Phylogenetic and Structural Insights into Melatonin Receptors in Plants: Case Study in Capsicum chinense Jacq [PDF]
PlantsRecently, it has been proposed that plant melatonin receptors belong to the superfamily of G protein-coupled receptors (GPCRs). However, a detailed description of the phylogeny, protein structure, and binding properties of melatonin, which is still ...
Adrian Toledo-Castiñeira +5 more
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A Review of Melatonin, Its Receptors and Drugs
Eurasian Journal of Medicine, 2019 After a Turkish scientist took Nobel Prize due to his contributions to understand clock genes, melatonin, closely related to these genes, may begin to shine.
Mucahit Emet +5 more
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Scientific Reports, 2017 Understanding the function of orphan G protein-coupled receptors (GPCRs), whose cognate ligand is unknown, is of major importance as GPCRs are privileged drug targets for many diseases. Recent phylogenetic studies classified three orphan receptors, GPR61,
Atsuro Oishi +5 more
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