Results 1 to 10 of about 2,385,196 (310)

Muscarinic receptor oligomerization [PDF]

Neuropharmacology, 2018
G protein-coupled receptors (GPCRs) have been classically described as monomeric entities that function by binding in a 1:1 stoichiometric ratio to both ligand and downstream signalling proteins.
Alvarez-Curto, Elisa, Marsango, Sara, Milligan, Graeme, Ward, Richard J.   +3 more
core   +4 more sources

All muscarinic acetylcholine receptors (M1-M5) are expressed in murine brain microvascular endothelium

Scientific Reports, 2017
Clinical and experimental studies indicate that muscarinic acetylcholine receptors are potential pharmacological targets for the treatment of neurological diseases.
Beatrice Mihaela Radu, Antonio Marco Maria Osculati, Eda Suku, Adela Banciu, Grygoriy Tsenov, Flavia Merigo, Marzia Di Chio, Daniel Dumitru Banciu, Cristina Tognoli, Petr Kacer, Alejandro Giorgetti, Mihai Radu, Giuseppe Bertini, Paolo Francesco Fabene   +13 more
doaj   +2 more sources

Allosteric Modulation of Muscarinic Acetylcholine Receptors

Pharmaceuticals, 2010
An allosteric modulator is a ligand that binds to an allosteric site on the receptor and changes receptor conformation to produce increase (positive cooperativity) or decrease (negative cooperativity) in the binding or action of an orthosteric agonist (e.
Esam E. El-Fakahany, Jan Jakubík
doaj   +2 more sources

Muscarinic Receptors

Handbook of Experimental Pharmacology, 2012
A. Fryer, A. Christopoulos, N. Nathanson
semanticscholar   +4 more sources

Acetylcholine receptors (muscarinic) in GtoPdb v.2023.1

IUPHAR/BPS Guide to Pharmacology CITE, 2023
Muscarinic acetylcholine receptors (mAChRs) (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [53]) are activated by the endogenous agonist acetylcholine. All five (M1-M5) mAChRs are ubiquitously expressed in the
Nigel J. M. Birdsall, S. Bradley, David A. Brown, Noel J. Buckley, R. A. Challiss, A. Christopoulos, R. Eglen, Frederick Ehlert, Christian C. Felder, Rudolf Hammer, H. Kilbinger, Günter Lambrecht, Chris Langmead, Fred Mitchelson, Ernst Mutschler, N. M. Nathanson, R. Schwarz, David M Thal, Andrew B. Tobin, C. Valant, Jürgen Wess   +20 more
semanticscholar   +1 more source

Acetylcholine receptors (muscarinic) in GtoPdb v.2021.3

IUPHAR/BPS Guide to Pharmacology CITE, 2021
Muscarinic acetylcholine receptors (mAChRs) (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [50]) are activated by the endogenous agonist acetylcholine. All five (M1-M5) mAChRs are ubiquitously expressed in the
N. Birdsall, S. Bradley, D. Brown, N. Buckley, R. Challiss, A. Christopoulos, R. Eglen, F. Ehlert, C. Felder, R. Hammer, H. Kilbinger, G. Lambrecht, C. Langmead, F. Mitchelson, E. Mutschler, N. Nathanson, R. Schwarz, D. Thal, A. Tobin, C. Valant, J. Wess   +20 more
semanticscholar   +1 more source

Acetylcholine receptors (muscarinic) in GtoPdb v.2021.2

IUPHAR/BPS Guide to Pharmacology CITE, 2021
Muscarinic acetylcholine receptors (mAChRs) (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [50]) are activated by the endogenous agonist acetylcholine. All five (M1-M5) mAChRs are ubiquitously expressed in the
Nigel J. M. Birdsall, S. Bradley, David A. Brown, Noel J. Buckley, R. A. Challiss, A. Christopoulos, R. Eglen, Frederick Ehlert, Christian C. Felder, Rudolf Hammer, H. Kilbinger, Günter Lambrecht, Chris Langmead, Fred Mitchelson, Ernst Mutschler, N. M. Nathanson, R. Schwarz, David M Thal, Andrew B. Tobin, C. Valant, Jürgen Wess   +20 more
semanticscholar   +1 more source

A growing understanding of the role of muscarinic receptors in the molecular pathology and treatment of schizophrenia

Frontiers in Cellular Neuroscience, 2023
Pre-clinical models, postmortem and neuroimaging studies all support a role for muscarinic receptors in the molecular pathology of schizophrenia. From these data it was proposed that activation of the muscarinic M1 and/or M4 receptor would reduce the ...
Brian Dean, Geor Bakker, Hiroki R. Ueda, Hiroki R. Ueda, Andrew B. Tobin, Alastair Brown, Richard A. A. Kanaan   +6 more
doaj   +1 more source

Neuromodulation of Persistent Activity and Working Memory Circuitry in Primate Prefrontal Cortex by Muscarinic Receptors

Frontiers in Neural Circuits, 2021
Neuromodulation by acetylcholine plays a vital role in shaping the physiology and functions of cerebral cortex. Cholinergic neuromodulation influences brain-state transitions, controls the gating of cortical sensory stimulus responses, and has been shown
Susheel Vijayraghavan, Stefan Everling, Stefan Everling   +2 more
doaj   +1 more source

Characterization of Bladder Selectivity of Antimuscarinic Agents on the Basis of Drug-Receptor Binding [PDF]

International Neurourology Journal, 2012
The in vivo muscarinic receptor binding of antimuscarinic agents (oxybutynin, solifenacin, tolterodine, and imidafenacin) used to treat urinary dysfunction in patients with overactive bladder is reviewed.
Shizuo Yamada, Shiori Kuraoka, Ayaka Osano, Yoshihiko Ito   +3 more
doaj   +1 more source