Results 101 to 110 of about 592,770 (271)

Modulation of DNA synthesis by muscarinic cholinergic receptors

, 2001
Acetylcholine muscarinic receptors are a family of five G-protein-coupled receptors widely distributed in the central nervous system and in peripheral organs.
Palmery, M, Costa, L. G, Federica Bordi, TITA, Beatrice, M. Guizetti, Paola Costa Mallen, Guizzetti, M, Tita, B, PALMERY, Maura, Oberdoerster, J, Bordi, F, VITALONE, Annabella, Yagle, K, VALERI, Pacifico, J. Oberdoester, Vitalone, A, COSTA, Lucio Guido, P. Yagle, Costa-Mallen, P, Valeri, P.   +19 more
core   +1 more source

Clinical Outcomes and Acute Exacerbation Incidence in Combined Pulmonary Fibrosis and Emphysema

Respirology, EarlyView.
This multicentre prospective study of 1016 patients demonstrated that CPFE, defined as ≥ 5% emphysema on visual CT assessment, identified a high‐risk phenotype with significantly worse 5‐year survival compared to non‐CPFE IIP patients (51.4% vs. 63.1%) and COPD patients (51.4% vs. 84.0%) and higher acute exacerbation incidence, validating international
Kazuya Tsubouchi, Yasuaki Kotetsu, Tomotsugu Takano, Hiroaki Ogata, Fumiaki Kiyomi, Katsuyuki Ichiki, Shohei Takata, Yasuhiko Kitasato, Hiroshi Ishii, Kazuhiro Yatera, Kei Yamasaki, Masaki Okamoto, Makoto Yoshida, Masayuki Kawasaki, Masaki Fujita, Tomohiro Ogawa, Kazunori Tobino, Eiji Harada, Noriaki Nakagaki, Masashi Komori, Taishi Harada, Hiroshi Wataya, Yoichi Nakanishi, Isamu Okamoto   +23 more
wiley   +1 more source

Inhaled Corticosteroid Escalation After a Single Moderate Exacerbation in COPD: Differential Benefit by Exacerbation Subtype

Respirology, EarlyView.
We tested whether ICS escalation after a single moderate COPD exacerbation improved outcomes according to exacerbation treatment phenotype. ICS reduced future exacerbations only in steroid‐treated events, not antibiotic‐treated events. This study supports phenotype‐guided escalation after one moderate exacerbation, avoiding overtreatment with precise ...
Sun Hye Shin, Jihye Heo, Ji Ye Jung, Juhee Cho, Dave Singh, Danbee Kang, Hye Yun Park   +6 more
wiley   +1 more source

Allosteric Modulation of Muscarinic Acetylcholine Receptors

Pharmaceuticals, 2010
An allosteric modulator is a ligand that binds to an allosteric site on the receptor and changes receptor conformation to produce increase (positive cooperativity) or decrease (negative cooperativity) in the binding or action of an orthosteric agonist (e.
Esam E. El-Fakahany, Jan Jakubík
doaj   +1 more source

Investigation of the Protective Effect of Morin on Oxidative Stress and Apoptosis in Malathion‐Induced Hepatotoxicity in Rats

Environmental Toxicology, EarlyView.
ABSTRACT Malathion (MAL) is a widely used organophosphate pesticide associated with hepatotoxicity through oxidative stress and apoptosis. Morin, a naturally occurring flavonoid, exhibits potent antioxidant and anti‐inflammatory properties. This study investigated oxidative stress, inflammatory, and apoptotic alterations induced by acute and subacute ...
Seval Yılmaz, Eda İ. Demirbağ, Hakan Bağ, Ali O. Çeribaşı   +3 more
wiley   +1 more source

Normal and Pathological Tau Uptake Mediated by M1/M3 Muscarinic Receptors Promotes Opposite Neuronal Changes

Frontiers in Cellular Neuroscience, 2019
The microtubule associated protein tau is mainly found in the cell’s cytosol but recently it was also shown in the extracellular space. In neurodegenerative diseases, like Alzheimer’s disease (AD), pathological tau spreads from neuron to neuron enhancing
Viktoriya Morozova, Viktoriya Morozova, Leah S. Cohen, Ali El-Hadi Makki, Alison Shur, Alison Shur, Guillermo Pilar, Abdeslem El Idrissi, Abdeslem El Idrissi, Alejandra D. Alonso, Alejandra D. Alonso   +10 more
doaj   +1 more source

Muscarinic acetylcholine receptors and airway diseases

, 2003
Parasympathetic nerves provide the dominant autonomic innervation of the airways. Release of acetylcholine from parasympathetic nerves activates postjunctional muscarinic receptors present on airway smooth muscle, submucosal glands, and blood vessels to ...
D. Fryer, Allison, Fiona R Coulson, Coulson, Fiona R., Coulson, Fiona, Allison D Fryer, Fryer, Allison D.   +5 more
core   +1 more source

Whole‐Genome Sequencing and Resequencing of Hucho bleekeri Provides Insights into Genetic Mechanisms of Environmental Adaptation

Integrative Zoology, EarlyView.
A high‐quality chromosome‐level reference genome was constructed for Hucho bleekeri. Population structure and environmental adaptation of Hucho species were revealed by whole‐genome resequencing. ABSTRACT Salmonidae represents an important family in the study of genome evolution following genome duplication.
Yeyu Chen, Huanchao Yang, Zhao Liu, Xiaoyun Wu, Qinyao Wei, Yanling Chen, Jue Lin, Yi Yu, Quanyu Tu, Hua Li   +9 more
wiley   +1 more source

Muscarinic Receptor Subtypes Mediating Positive and Negative Inotropy in the Developing Chick Ventricle

Journal of Pharmacological Sciences, 2007
The inotropic response to muscarinic receptor stimulation of isolated chick ventricular myocardium was examined at various developmental stages, and the receptor subtype involved was pharmacologically characterized.
Hideaki Nouchi, Seri Kaeriyama, Akiko Muramatsu, Masumi Sato, Kunihiko Hirose, Nagako Shimizu, Hikaru Tanaka, Koki Shigenobu   +7 more
doaj   +1 more source

Diet–Microbiome–Immune Interactions at the Gut Mucosa in Food Allergy: Mechanisms, Gaps, and Therapeutic Implications

Allergy, EarlyView.
ABSTRACT Mucosal surfaces are sites of highly dynamic interactions among epithelial and immune cells, environmental exposures, particularly dietary inputs, and the diverse microbial communities and their metabolites. These elements continually influence each other to maintain homeostasis and ensure appropriate immune discrimination between pathogens ...
Clara Delaroque, Liam O'Mahony, Inge Kortekaas Krohn, Charlotte G. Mortz, Markus Ollert, Mahesh S. Desai   +5 more
wiley   +1 more source