Results 171 to 180 of about 43,677 (218)

Structure and Regulation of Muscarinic Receptors

Annual Review of Physiology, 1989
Our knowledge of muscarinic receptor structure, mechanism, and regulation has increased enormously over the past five years. At this time, expression of receptor subtype and coupling via signal transducing elements to specific effector systems seems to be cell or tissue specific events.
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Interaction of Atropine with the Muscarinic Receptor

Nature, 1970
WE report here the crystal structures of two muscarinic antagonists of acetylcholine, (−)-(S)-hyoscine hydrobromide1 and (−)-(S)-hyoscyamine hydrobromide (atropine). Correlation of these two structures and that of quinuclidinyl benzilate hydrobromide2 shows marked similarities among the three molecules although they are subjected to very different ...
P J, Pauling, T J, Petcher
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Endocytosis and recycling of muscarinic receptors

Life Sciences, 1999
Agonist stimulation causes the endocytosis of many G protein-coupled receptors, including muscarinic acetylcholine receptors. In this study we have investigated the agonist-triggered trafficking of the M3 muscarinic receptor expressed in SH-SY5Y human neuroblastoma cells.
J M, Edwardson, P G, Szekeres
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Muscarinic receptors in rat uterus

European Journal of Pharmacology, 1994
The aim of this study was to characterise the muscarinic receptor present in the uterus of the virgin rat. Homogenate binding studies were undertaken using [3H]quinuclidinyl benzilate as the radioligand and atropine (10 microM) to determine non-specific binding.
J N, Pennefather, T A, Gillman, F, Mitchelson   +2 more
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Antidepressants and the Muscarinic Acetylcholine Receptor

Archives of General Psychiatry, 1977
Several tricyclic antidepressants have been assessed for their potency in binding to the muscarinic acetylcholine receptor of brain and intestine. Amitriptyline hydrochloride is about ten times as potent as imipramine hydrochloride. Dimethylated drugs are more potent than monomethylated ones.
S H, Snyder, H I, Yamamura
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Regulation of muscarinic M2 receptors

Life Sciences, 1997
The molecular mechanisms involved in the regulation of muscarinic receptor gene expression are poorly understood. In an effort to gain a better understanding of the regulation of M2 receptors, we have investigated homologous and heterologous regulation of M2 muscarinic receptor protein and gene expression in human embryonic lung fibroblasts (HEL 299 ...
P J, Barnes, E B, Haddad, J, Rousell
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Heterogeneity of vascular muscarinic receptors

Journal of Autonomic Pharmacology, 1990
SummaryMuscarinic receptors mediate diverse effects on the vasculature. Recently, a consensus has been arrived at with regard to muscarinic receptor classification (Levine and Birdsall, 1989). As a result, it may now be possible to clarify the role of each subtype in the responses of vascular tissues to muscarinic agonists. It is apparent that vascular
R M, Eglen, R L, Whiting
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Constitutively active muscarinic receptors

Life Sciences, 2001
Mutations that increase constitutive activity and alter ligand binding have been used to investigate the structure and mechanism of activation of muscarinic receptors. These data are reviewed with reference to the recently published three-dimensional structure of rhodopsin.
T A, Spalding, E S, Burstein
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The Muscarinic Receptors

1984
Muscarinic receptors exist in both peripheral tissues and the central nervous system. Their activation is responsible for all the effects elicited by parasympathetic stimulation in the peripheral organs and modulate ganglionic transmission (Wallis, 1979).
Giancarlo Pepeu, Ileana Marconcini Pepeu
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Muscarinic Receptors

Nature, 1961
A H, BECKETT, N J, HARPER, J W, CLITHEROW, E, LESSER   +3 more
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