Results 151 to 160 of about 84,180 (270)
Journal of Internal Medicine, Volume 299, Issue 6, Page 694-710, June 2026.Abstract Alzheimer's disease (AD) is neuropathologically defined by amyloid‐beta (Aβ) plaques and tau neurofibrillary tangles. However, co‐pathologies and other pathobiological processes are involved in the pathogenesis of AD, contributing to neurodegeneration and clinical symptoms.
Daniel Ferreira +9 more
wiley +1 more source
Health Science Reports, Volume 9, Issue 5, May 2026.ABSTRACT Background and Aims Xerostomia, or dry mouth, significantly impairs quality of life and oral health, particularly in patients subjected to radiation therapy or suffering from systemic disorders. This narrative review summarizes the current evidence on the efficacy and safety of gene therapy interventions for xerostomia, exploring innovative ...
Muhammad Usman Bilal +6 more
wiley +1 more source
Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by Gβγ subunits and function as heteromultimers [PDF]
, 1995 Guanine nucleotide-binding proteins (G proteins) activate K+ conductances in cardiac atrial cells to slow heart rate and in neurons to decrease excitability. cDNAs encoding three isoforms of a G-protein-coupled, inwardly rectifying K+ channel (GIRK) have
Davidson, Norman +2 more
core
IJU Case Reports, Volume 9, Issue 3, May 2026.ABSTRACT Introduction Pediatric neurogenic lower urinary tract dysfunction (NLUTD) is commonly managed with anticholinergic agents and clean intermittent catheterization (CIC). However, treatment options are limited for patients who remain resistant to conventional therapy, particularly following spinal cord surgery. Case Presentation A 14‐year‐old boy
Kohei Mori +7 more
wiley +1 more source
Journal of Pediatric Gastroenterology and Nutrition, Volume 82, Issue 5, Page 1153-1161, May 2026.Abstract Objectives Vonoprazan, a potassium‐competitive acid blocker, provides more rapid, potent, and durable elevations in gastric pH than proton pump inhibitors in adults and may be a treatment option for adolescents and children with gastroesophageal reflux disease (GERD).
Darcy J. Mulford +6 more
wiley +1 more source
Enteric Nervous System Damage by Food Contaminants: A Pathway to Neurodegeneration?
Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.ABSTRACT The enteric nervous system (ENS), a key component of the gut–brain axis, has emerged as a critical player in the pathogenesis of Parkinson's disease (PD). It is the first neural system exposed to food contaminants (FCs)—a diverse group of ubiquitous toxic compounds fortuitously present in food derived from production, processing, storage, or ...
Helena Ramos +3 more
wiley +1 more source
Multi‐Omics Reveals Dysregulated Neurotransmitter Systems in Aging and CNS Disorders
Aging Cell, Volume 25, Issue 5, May 2026.Integrating large‐scale human snRNA‐seq, spatial transcriptomics, and cerebral organoid datasets reveals cell‐type‐specific neurotransmitter‐system remodeling across aging and CNS disorders. Shared and disease‐specific NTS alterations highlight candidate mechanisms, sex differences, and exploratory discriminatory signals that may guide mechanistic ...
Rui‐Ze Niu +11 more
wiley +1 more source
Acta Psychiatrica Scandinavica, Volume 153, Issue 5, Page 402-431, May 2026.ABSTRACT Background Schizophrenia is characterized by positive, negative, and cognitive symptoms. Current pharmacological treatments often fail to address cognitive deficits. In this review of clinical trials, we aim to identify studies that explore neurobiological (non‐psychological) strategies to address Cognitive Impairment Associated with ...
Bahareh Peyrovian +3 more
wiley +1 more source
Allergy, Volume 81, Issue 5, Page 1617-1634, May 2026.This study identifies that Ach levels are elevated in eCRSwNP and primarily released from SCCs rather than neurons. Ach induces epithelial remodeling in eCRSwNP by binding to M1R/M3R and activating YAP signaling in basal cells, driving basal cell hyperplasia and abnormal differentiation. Blocking M1R/M3R with TB inhibits eCRSwNP progression.
Bowen Zheng +20 more
wiley +1 more source
Allergy, Volume 81, Issue 5, Page 1548-1570, May 2026.This meta‐analysis included 2292 patients with severe asthma who underwent biologic switching across 23 countries/regions. The most prevalent switching pattern was from mepolizumab to benralizumab, with suboptimal asthma control being the primary reason.
Yang Zheng +13 more
wiley +1 more source