Results 141 to 150 of about 592,770 (271)

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source

Neurocardiac crosstalk in inherited cardiac arrhythmias and cardiomyopathy

The Journal of Physiology, EarlyView.
Abstract figure legend In inherited cardiac arrhythmias and cardiomyopathy, arrhythmias are typically triggered by autonomic nervous system activity. Genetic mutations linked to these conditions cause pro‐arrhythmic alterations in both cardiomyocytes and neurons, with their pathophysiological crosstalk likely amplifying the manifestation of the disease.
Carol Ann Remme, Molly O'Reilly
wiley   +1 more source

Muscarinic Receptors and Gastrointestinal Smooth Muscle

, 1987
Muscarinic acetylcholine M2 and M3 receptor subtypes are coexpressed in many types of smooth muscle including gastrointestinal smooth muscle, urinary bladder and vascular and airway tissue.
Thomas, Elizabeth A., Gersten, Edward H., Griffin, Michael T., Ehlert, Frederick J.   +3 more
core   +1 more source

Mechanisms reducing parasympathetic activity in chronic hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Parasympathetic activity is reduced in chronic hypoxia, but the underlying mechanism(s) are unclear. Using β‐adrenergic blockade to isolate parasympathetic control of heart rate at sea level and after 9‐12 days at high altitude, we investigated whether (i) chemoreflex activation, (ii) increased pulmonary ventilation and/or (iii ...
Lauren E. Maier, Andrew Douglas, Katharine Foster, Elliott J. Jenkins, Liam D. Corr, Peter Rasmussen, James Anholm, Travis D. Gibbons, Phil N. Ainslie, Mike Stembridge, Christoph Siebenmann   +10 more
wiley   +1 more source

Myostatin‐dependent detrusor remodelling mediates contractility impairment in diabetic rats’ bladder – a maximal elastance analysis

The Journal of Physiology, EarlyView.
Abstract figure legend In the muscular layer of long‐standing diabetic bladders increased myostatin expression promotes tissue remodelling by reducing the muscle‐to‐collagen ratio, ultimately diminishing bladder contractility. Maximal elastance – defined as the slope of the end‐emission pressure–volume relationship (EPR), derived from the regression ...
Cheng‐Yuan Lai, Hui‐Hsuan Lau, Ming‐Chun Hsieh, Hsien‐Yu Peng, Dylan Chou, Tsung‐Hsien Su, Tzer‐Bin Lin   +6 more
wiley   +1 more source

Sex Differences in Prescribing Patterns of Anticholinergics and β3‐Adrenoceptor Agonists for Overactive Bladder: A Nationwide Study in Japan, FY2017–FY2024

LUTS: Lower Urinary Tract Symptoms, Volume 18, Issue 6, November 2026.
ABSTRACT Objectives Drug treatment for overactive bladder (OAB) is changing, with an increasing share of β3‐adrenoceptor agonists relative to anticholinergics, but it is not known how far this change has progressed in older people, who are most vulnerable to the risks of anticholinergics.
Toshikazu Koike, Takashi Kawahara, Akihito Hashizume, Masanobu Yamazaki, Daiji Takamoto, Hiroki Ito, Teppei Takeshima, Hiroji Uemura, Kazuhide Makiyama, Jun‐Ichi Teranishi   +9 more
wiley   +1 more source

Real‐World Management of Difficult Exacerbations of Bronchiectasis: A Case Study to Illustrate How Guidelines Can Support Best Practice

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Timely management of exacerbations and optimisation of ongoing care are vital in preventing disease progression and preserving outcomes and quality of life in patients with bronchiectasis. This retrospective case review underscores the importance of the new ERS guidelines in supporting multidisciplinary teams to provide optimal care for their ...
Hulance Bianca, Capstick Toby, Shah Anand, McCallion Paul   +3 more
wiley   +1 more source

The Role of Anterior Insular Parvalbumin GABAergic Interneurons in Impulsivity‐Related and Alcohol‐Seeking Behaviors

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Adolescent impulsivity is linked to increased alcohol seeking and altered activation of anterior insular PV interneurons. Chemogenetic modulation of these neurons regulates inhibitory control and alcohol‐related behaviors, highlighting their role in vulnerability to alcohol use disorder.
F. Bezerra, G. J. D. Fernandes, A. Anjos‐Santos, C. A. Favoretto, B. T. Rodolpho, P. Palombo, V. Vialou, K. P. Abrahao, F. C. Cruz   +8 more
wiley   +1 more source

N-Arachidonoyl-phosphatidylethanolamide phospholipase D activation by muscarinic receptors. [PDF]

J Physiol
Murataeva N, Schmitt C, Hyman E, Wager-Miller J, Matthews I, Cai R, Cai S, Li Y, Mackie K, Straiker A.   +9 more
europepmc   +1 more source

Müller Glia–Vasculature Interactions in the Developing Retina

Glia, Volume 74, Issue 10, October 2026.
Retinal vascular layers form normally despite loss of cholinergic retinal waves. Müller glial processes contact endothelial tip cells early and form Aquaporin‐4‐enriched endfeet. Glial endfoot calcium signals are compartmentalized and occur largely independently of neural activity. ABSTRACT Coordinated signaling among neurons, glia, and the vasculature
Samira Monshietehadi, Angel J. Garcia, Benjamin E. Smith, Matthew Tarchick, Kiara Abhayaratne, Aileen Conley, Marla B. Feller   +6 more
wiley   +1 more source