Results 181 to 190 of about 83,236 (271)

Synthetic microneurotrophins: Neurotrophin receptors for therapeutics of neurodegenerative diseases

British Journal of Pharmacology, Volume 182, Issue 19, Page 4466-4489, October 2025.
Neurodegenerative disorders are characterised by the chronic progressive degeneration of specific neuronal subtypes, neuroinflammation, myelin damage and synaptic loss. Despite their growing incidence, advancements in effective treatments remain limited, because of lack of knowledge for the aetiology of the diverse pathophysiology to design systematic ...
Ioanna Zota, Theodora Calogeropoulou, Konstantina Chanoumidou, Ioannis Charalampopoulos, Achille Gravanis   +4 more
wiley   +1 more source

Bioorganic Chemistry, Toxinology, and Pharmaceutical Uses of <i>Datura</i> Metabolites and Derivatives. [PDF]

Toxins (Basel)
Thawabteh AM, Sulaiman S, Alabed IO, Scrano L, Karaman D, Karaman R, Bufo SA.   +6 more
europepmc   +1 more source

Critical insights into the potential risks of antipsychotic drugs to fish, including through effects on behaviour

Biological Reviews, Volume 100, Issue 5, Page 1994-2019, October 2025.
ABSTRACT Antipsychotic drugs (APDs) are a diverse class of neuroactive pharmaceuticals increasingly detected in surface and ground waters globally. Some APDs are classified as posing a high environmental risk, due, in part, to their tendency to bioaccumulate in wildlife, including fish.
Gabrielle Wasser‐Bennett, A. Ross Brown, Samuel K. Maynard, Stewart F. Owen, Charles R. Tyler   +4 more
wiley   +1 more source

From theory to therapy: unlocking the potential of muscarinic receptor activation in schizophrenia with the dual M1/M4 muscarinic receptor agonist xanomeline and trospium chloride and insights from clinical trials. [PDF]

Int J Neuropsychopharmacol
Meyer JM, Kramer K, Vuocolo S, Kaul I, Miller AC.   +4 more
europepmc   +1 more source

Muscarinic acetylcholine receptors

Japanese Journal of Pharmacology, 1978
Kunio Takeyasu, Shuji Uchida, Hiroshi Yoshida, Norifumi Yonehara   +3 more
openaire   +2 more sources

Hyperhidrosis: don't sweat it

Internal Medicine Journal, Volume 55, Issue 10, Page 1626-1631, October 2025.
Abstract Hyperhidrosis is an under‐reported and under‐treated condition that causes significant patient morbidity. Secondary causes require consideration, but the vast majority of cases are idiopathic. The condition is encountered by a range of clinicians, including neurologists, dermatologists and endocrinologists, and it pays to be familiar with the ...
Mitchell J. Lycett, Karl Ng
wiley   +1 more source

The role of acetylcholine and its receptors in tumor immune regulation: mechanisms and potential therapeutic targets. [PDF]

Mol Cancer
Zhang C, Guo X, Wang Y, Zhang S, Wang Z.
europepmc   +1 more source

Impairment of Group I Metabotropic Glutamate Receptors in the Dorsal Striatum of the R451C‐Neuroligin 3 Mouse Model of Autism Spectrum Disorder

Journal of Neurochemistry, Volume 169, Issue 10, October 2025.
The dorsal and ventral regions of the striatum represent key brain areas for the expression of Autism Spectrum Disorder (ASD) core symptoms. In the present work, we report that different forms of long‐term synaptic plasticity are impaired in the dorsal striatum of a phenotypic mouse model of ASD, carrying the ASD‐associated R451C mutation in the ...
Maria Meringolo, Martina Montanari, Simona D'Antoni, Giuseppina Martella, Ilham El Atiallah, Giulia Ponterio, Annalisa Tassone, Ingrid Reverte, Daniele Caprioli, Georgios Strimpakos, Luisa Pieroni, Maria Vincenza Catania, Paola Bonsi   +12 more
wiley   +1 more source

Impaired neuromodulator crosstalk delays arousal-dependent astroglia Ca²⁺ activation in mouse models of Alzheimer's disease. [PDF]

iScience
Heo EY, Salinas-Birt A, Ye L, Sajadi S, Sarker MK, Yang Y, Paukert M.   +6 more
europepmc   +1 more source

Astrocytes as Active Participants in Memory

Journal of Neurochemistry, Volume 169, Issue 10, October 2025.
This review explores how astrocytes support memory by modulating neurotransmitters, interacting with biomolecules, and taking part in synaptic plasticity. We discuss their role across various brain regions and spotlight cutting‐edge methods—such as Ca2+ imaging, optogenetics, chemogenetics, and engram analysis—that have revolutionized our ability to ...
Shay Meron Asher, Inbal Goshen
wiley   +1 more source