Results 181 to 190 of about 41,494 (257)

Layer‐Specific Connectivity and Functional Interference of Chrna2+ Layer 5 Martinotti Cells in the Primary Motor Cortex

European Journal of Neuroscience, Volume 61, Issue 7, April 2025.
Chrna2+ Martinotti cells (Mα2cells) in the primary motor cortex (M1) receive monosynaptic long‐range inputs from secondary motor cortex (M2), primary somatosensory cortex (S1), ventral anterolateral complex of the thalamus (VAL), globus pallidus externa (GPe), and substantia innominata (SI).
Anna Velica, Katharina Henriksson, Thawann Malfatti, Barbara Ciralli, Ingrid Nogueira, Evridiki Asimakidou, Klas Kullander   +6 more
wiley   +1 more source

European Academy of Neurology (EAN)/European Federation of Autonomic Societies (EFAS)/International Neuro‐Urology Society (INUS) Guidelines for Practising Neurologists on the Assessment and Treatment of Neurogenic Urinary and Sexual Symptoms (NEUROGED Guidelines)

European Journal of Neurology, Volume 32, Issue 4, April 2025.
ABSTRACT Background Urinary and sexual symptoms are common following neurological disease, and we aimed to develop multidisciplinary inter‐society evidence‐based management guidelines. Methods The ADAPTE framework was used, and a systematic search of guidelines published in different languages was performed.
Jalesh N. Panicker, Alessandra Fanciulli, Magdalena Krbot Skoric, Tamara Kaplan, Katina Aleksovska, Ivan Adamec, Marcio Augusto Averbeck, Nicole Campese, Pietro Guaraldi, Fabian Leys, Jorge Moreno‐Palacios, Sara Simeoni, Iva Stankovic, Sarah Wright, Amit Batla, Bertil Blok, Claire Hentzen, Max Josef Hilz, Thomas M. Kessler, Helmut Madersbacher, Kannan Rajasekharan Nair, Krishnan Padmakumari Sivaraman Nair, Mahreen Pakzad, Anne Pavy‐Le Traon, Guy Peryer, Mikolaj Przydacz, Ryuji Sakakibara, Udit Saraf, Matthew Smith, Walter Struhal, Roland D. Thijs, Katarina Ivana Tudor, Marcin Tutaj, David B. Vodušek, Gregor Wenning, Mario Habek   +35 more
wiley   +1 more source

Third-Generation Antipsychotics: The Quest for the Key to Neurotrophism. [PDF]

Life (Basel)
Mucci F, Arone A, Gurrieri R, Weiss F, Russomanno G, Marazziti D.   +5 more
europepmc   +1 more source

Acute and persistent changes in neural oscillatory activity predict development of epilepsy following acute organophosphate intoxication in adult rats

Epilepsia, Volume 66, Issue 4, Page 1329-1342, April 2025.
Abstract Objective Acute organophosphate (OP) intoxication affects a significant number of individuals worldwide. Those who survive OP‐induced cholinergic crisis, which includes status epilepticus, often develop neurological morbidities. Here, we provide a rigorous characterization of the acute and delayed electrophysiological responses to OP ...
Jeremy A. MacMahon, Peter M. Andrew, Ali Izadi, Donald A. Bruun, Naomi H. Saito, Daniel J. Tancredi, Amy Brooks‐Kayal, Pamela J. Lein, Gene G. Gurkoff   +8 more
wiley   +1 more source

Neurotransmitters' white matter mapping unveils the neurochemical fingerprints of stroke. [PDF]

Nat Commun
Alves PN, Nozais V, Hansen JY, Corbetta M, Nachev P, Martins IP, Thiebaut de Schotten M.   +6 more
europepmc   +1 more source

Characterization of multiple binding sites on microtubule associated protein 2c recognized by dimeric and monomeric 14‐3‐3ζ

The FEBS Journal, Volume 292, Issue 8, Page 1991-2016, April 2025.
Microtubule associated protein 2c (MAP2c) interacts with the regulatory protein 14‐3‐3ζ in a phosphorylation‐dependent manner. In its unphosphorylated state, MAP2c binds 14‐3‐3ζ via its microtubule binding domain and its central region. However, upon phosphorylation by cAMP‐dependent protein kinase (PKA), 14‐3‐3ζ preferentially binds to the ...
Séverine Jansen, Subhash Narasimhan, Paula Cabre Fernandez, Lucia Iľkovičová, Aneta Kozeleková, Kateřina Králová, Jozef Hritz, Lukáš Žídek   +7 more
wiley   +1 more source

Discovering Key Activation Hotspots in the M₂ Muscarinic Receptor. [PDF]

J Am Chem Soc
Sugiura Y, Ikuta T, Sumii Y, Tsujimoto H, Suzuki K, Suno R, Ariff PNABM, Iwata S, Shibata N, Inoue A, Kobayashi T, Kandori H, Katayama K.   +12 more
europepmc   +1 more source

Succinate receptor 1 signaling mutually depends on subcellular localization and cellular metabolism

The FEBS Journal, Volume 292, Issue 8, Page 2017-2050, April 2025.
SUCNR1, activated by succinate, is a Gi‐ and Gq‐coupled receptor present at the plasma membrane and in endosomes. There are conflicting reports about the pro‐/anti‐inflammatory effects of the succinate‐SUCNR1 signaling axis, and these are likely due to localization‐dependent signaling.
Aenne‐Dorothea Liebing, Philipp Rabe, Petra Krumbholz, Christian Zieschang, Franziska Bischof, Angela Schulz, Susan Billig, Claudia Birkemeyer, Thanigaimalai Pillaiyar, Mikel Garcia‐Marcos, Robert Kraft, Claudia Stäubert   +11 more
wiley   +1 more source

Selectivity of bethanechol on muscarinic receptors

Journal of Pharmacy and Pharmacology, 1978
openaire   +3 more sources

Anticholinergic burden quantified using the Japanese risk scale as a predictor of frailty and sarcopenia among community‐dwelling older adults: A 9‐year Kashiwa cohort study

Geriatrics &Gerontology International, Volume 25, Issue 4, Page 520-527, April 2025.
Anticholinergic burden, quantified using the Japanese Anticholinergic Drug Risk Scale, may be a predictor of frailty and sarcopenia in community‐dwelling older adults. Effective evaluation and management of anticholinergic burden using the Japanese Anticholinergic Drug Risk Scale are crucial for promoting healthy aging and mitigating adverse health ...
Tomoki Tanaka, Masahiro Akishita, Taro Kojima, Bo‐Kyung Son, Katsuya Iijima   +4 more
wiley   +1 more source