Results 211 to 220 of about 2,302,872 (259)
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Muscarinic receptors in pineal
Life Sciences, 1980Abstract The presence of muscarinic receptors in sheep and rat pineals was detected by binding of [ 3 H]quinuclidinyl benzilate ([ 3 H]QNB), a potent and specific muscarinic antagonist. [ 3 H]QNB binding to sheep pineal membrane resuspensions was saturable and reversible, with a rate constant for association at 37°C of 6×10 8 M −1 min −1 and a rate ...
Richard L. Taylor +2 more
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Muscarinic acetylcholine receptor
Progress in Neurobiology, 1978ABSTRACT Muscarinic acetylcholine receptors from rat cerebral cortex and small intestine were studied by the high affinity and high specific activity antagonists 3 H-3-quinuclidinyl benzilate (3-QNB) (29.4 Ci/mmol) and 3 H-N-methyl-4-piperidinyl benzilate (4-NMPB) (55.4 Ci/mmol).
Edith Heilbronn, Tamas Bartfai
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Desensitization of Muscarinic Receptors
Receptors and Channels, 2004When Chinese hamster ovary cells transfected with the gene for M(3)-muscarinic receptors were stimulated with carbachol continuously for 30 min, the response at the end of the stimulation period was about 20% of the early response (2-3 min after the start of the stimulation).
J Van Emmelo +3 more
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Calcium and the muscarinic receptor
General Pharmacology: The Vascular System, 1976Pharmacological receptors may be viewed as composed of two linked functions, a recognition site through which the specificity and selectivity of ligand action is expressed and an amplification or catalytic site which translates the ligand-recognition site interaction into response.
David J. Triggle, M.K. Ticku
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Muscarinic M₃ receptors contribute to allergen-induced airway remodeling in mice.
American Journal of Respiratory Cell and Molecular Biology, 2014Asthma is a chronic obstructive airway disease, characterized by inflammation and remodeling. Acetylcholine contributes to symptoms by inducing bronchoconstriction via the muscarinic M3 receptor.
L. Kistemaker +8 more
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Muscarinic Receptors in Schizophrenia
Current Molecular Medicine, 2003An increasing body of evidence suggests that the muscarinic receptors may present a potential therapeutic target for the treatment of schizophrenia. This argument is supported by studies using postmortem CNS tissue and a neuroimaging study that have shown there are regionally specific decreases in selective muscarinic receptors in the CNS of subjects ...
Elizabeth Scarr +2 more
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Pharmacological approaches to targeting muscarinic acetylcholine receptors.
Recent Patents on CNS Drug Discovery, 2014The presence of cholinergic system markers and muscarinic receptor subtypes in several tissues also of nonneuronal type has been largely demonstrated. Acetylcholine, synthesized in the nervous system, can locally contribute to modulate cell proliferation,
C. Matera, A. Tata
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Muscarinic Acetylcholine Receptors
Current Pharmaceutical Design, 2006Muscarinic acetylcholine receptors mediate diverse physiological functions. At present, five receptor subtypes (M(1) - M(5)) have been identified. The odd-numbered receptors (M(1), M(3), and M(5)) are preferentially coupled to G(q/11) and activate phospholipase C, which initiates the phosphatidylinositol trisphosphate cascade leading to intracellular ...
Masaru Ishii, Yoshihisa Kurachi
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The Muscarinic Receptors [PDF]
, 1984 Muscarinic receptors exist in both peripheral tissues and the central nervous system. Their activation is responsible for all the effects elicited by parasympathetic stimulation in the peripheral organs and modulate ganglionic transmission (Wallis, 1979).
Giancarlo Pepeu, Ileana Marconcini Pepeu
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Muscarinic Receptor Antagonists
2016Parasympathetic activity is increased in patients with chronic obstructive pulmonary disease (COPD) and asthma and appears to be the major reversible component of airway obstruction. Therefore, treatment with muscarinic receptor antagonists is an effective bronchodilator therapy in COPD and also in asthmatic patients.
Maria Gabriella Matera, Mario Cazzola
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