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Cobenfy (Xanomeline-Trospium Chloride): A New Frontier in Schizophrenia Management. [PDF]
Hasan AH, Abid MA.
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Annual Review of Pharmacology and Toxicology, 1990
In 1914, Sir Henry Dale provided the basis for the classical and comfortable definition of muscarinic and nicotinic acetylcholine receptors: Muscarinic receptors are selectively activated by muscarine and blocked by atropine; nicotinic receptors are activated by nicotine and blocked by curare.
Nigel J. M. Birdsall+2 more
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In 1914, Sir Henry Dale provided the basis for the classical and comfortable definition of muscarinic and nicotinic acetylcholine receptors: Muscarinic receptors are selectively activated by muscarine and blocked by atropine; nicotinic receptors are activated by nicotine and blocked by curare.
Nigel J. M. Birdsall+2 more
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Muscarinic Receptor Trafficking [PDF]
Knowledge of the mechanisms responsible for the trafficking of neurotransmitter receptors away from the cell surface is of obvious importance in understanding what regulates their expression and function. This chapter will focus on the mechanisms responsible for the internalization and degradation of muscarinic receptors.
Neil M. Nathanson, Cindy Reiner
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MUSCARINIC RECEPTOR DIFFERENTIATION
Clinical and Experimental Pharmacology and Physiology, 1989SUMMARY1. Several selective antagonists are available to differentiate between muscarinic receptors.2. Further subdivision of M1 and M2 muscarinic receptors appears possible and is supported by studies with cloned receptors.3. Reasons for differences between affinity constants determined in functional and binding studies and whether receptor subtypes ...
S Darroch+2 more
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