Results 231 to 240 of about 84,180 (270)

Muscarinic Receptor Antagonists

2016
Parasympathetic activity is increased in patients with chronic obstructive pulmonary disease (COPD) and asthma and appears to be the major reversible component of airway obstruction. Therefore, treatment with muscarinic receptor antagonists is an effective bronchodilator therapy in COPD and also in asthmatic patients.
Maria Gabriella, Matera, Mario, Cazzola
openaire   +2 more sources

ON THE MUSCARINIC RECEPTORS IN THE URINARY BLADDER AND THE PUTATIVE SUBCLASSIFICATION OF MUSCARINIC RECEPTORS

Acta Pharmacologica et Toxicologica, 1986
Abstract:The muscarinic cholinergic receptors in the urinary bladders of man, guinea pig, rat and rabbit were studied by means of a receptor binding technique, with L‐quinuclidinyl [phenyl4‐3H]benzilate, (‐)3H‐QNB, as radioligand. The potential role of the receptors in the supersensitivity of the rat bladder to muscarinic agonists, following ...
openaire   +2 more sources

Structure and Regulation of Muscarinic Receptors

Annual Review of Physiology, 1989
Our knowledge of muscarinic receptor structure, mechanism, and regulation has increased enormously over the past five years. At this time, expression of receptor subtype and coupling via signal transducing elements to specific effector systems seems to be cell or tissue specific events.
openaire   +2 more sources

Interaction of Atropine with the Muscarinic Receptor

Nature, 1970
WE report here the crystal structures of two muscarinic antagonists of acetylcholine, (−)-(S)-hyoscine hydrobromide1 and (−)-(S)-hyoscyamine hydrobromide (atropine). Correlation of these two structures and that of quinuclidinyl benzilate hydrobromide2 shows marked similarities among the three molecules although they are subjected to very different ...
P J, Pauling, T J, Petcher
openaire   +2 more sources

Endocytosis and recycling of muscarinic receptors

Life Sciences, 1999
Agonist stimulation causes the endocytosis of many G protein-coupled receptors, including muscarinic acetylcholine receptors. In this study we have investigated the agonist-triggered trafficking of the M3 muscarinic receptor expressed in SH-SY5Y human neuroblastoma cells.
J M, Edwardson, P G, Szekeres
openaire   +2 more sources

Regulation of muscarinic M2 receptors

Life Sciences, 1997
The molecular mechanisms involved in the regulation of muscarinic receptor gene expression are poorly understood. In an effort to gain a better understanding of the regulation of M2 receptors, we have investigated homologous and heterologous regulation of M2 muscarinic receptor protein and gene expression in human embryonic lung fibroblasts (HEL 299 ...
P J, Barnes, E B, Haddad, J, Rousell
openaire   +2 more sources

Heterogeneity of vascular muscarinic receptors

Journal of Autonomic Pharmacology, 1990
SummaryMuscarinic receptors mediate diverse effects on the vasculature. Recently, a consensus has been arrived at with regard to muscarinic receptor classification (Levine and Birdsall, 1989). As a result, it may now be possible to clarify the role of each subtype in the responses of vascular tissues to muscarinic agonists. It is apparent that vascular
R M, Eglen, R L, Whiting
openaire   +2 more sources

Muscarinic receptors in rat uterus

European Journal of Pharmacology, 1994
The aim of this study was to characterise the muscarinic receptor present in the uterus of the virgin rat. Homogenate binding studies were undertaken using [3H]quinuclidinyl benzilate as the radioligand and atropine (10 microM) to determine non-specific binding.
J N, Pennefather, T A, Gillman, F, Mitchelson   +2 more
openaire   +2 more sources

Muscarinic acetylcholine receptors: novel opportunities for drug development

Nature Reviews Drug Discovery, 2014
Andrew C Kruse, Brian K Kobilka, Dinesh Gautam   +2 more
exaly  

Towards a muscarinic hypothesis of schizophrenia

Molecular Psychiatry, 2006
Brian Dean
exaly