Results 221 to 230 of about 41,494 (257)

Muscarinic receptors in pineal

Life Sciences, 1980
Abstract The presence of muscarinic receptors in sheep and rat pineals was detected by binding of [ 3 H]quinuclidinyl benzilate ([ 3 H]QNB), a potent and specific muscarinic antagonist. [ 3 H]QNB binding to sheep pineal membrane resuspensions was saturable and reversible, with a rate constant for association at 37°C of 6×10 8 M −1 min −1 and a rate ...
Richard L. Taylor, David R. Burt, Maria Luiza C. Albuquerque   +2 more
openaire   +3 more sources

Muscarinic acetylcholine receptor

Progress in Neurobiology, 1978
ABSTRACT Muscarinic acetylcholine receptors from rat cerebral cortex and small intestine were studied by the high affinity and high specific activity antagonists 3 H-3-quinuclidinyl benzilate (3-QNB) (29.4 Ci/mmol) and 3 H-N-methyl-4-piperidinyl benzilate (4-NMPB) (55.4 Ci/mmol).
Edith Heilbronn, Tamas Bartfai
openaire   +4 more sources

Desensitization of Muscarinic Receptors

Receptors and Channels, 2004
When Chinese hamster ovary cells transfected with the gene for M(3)-muscarinic receptors were stimulated with carbachol continuously for 30 min, the response at the end of the stimulation period was about 20% of the early response (2-3 min after the start of the stimulation).
J Van Emmelo, Karen Vermis, Norbert Fraeyman, Rh Paulssen   +3 more
openaire   +3 more sources

Calcium and the muscarinic receptor

General Pharmacology: The Vascular System, 1976
Pharmacological receptors may be viewed as composed of two linked functions, a recognition site through which the specificity and selectivity of ligand action is expressed and an amplification or catalytic site which translates the ligand-recognition site interaction into response.
David J. Triggle, M.K. Ticku
openaire   +3 more sources

Muscarinic Receptors in Schizophrenia

Current Molecular Medicine, 2003
An increasing body of evidence suggests that the muscarinic receptors may present a potential therapeutic target for the treatment of schizophrenia. This argument is supported by studies using postmortem CNS tissue and a neuroimaging study that have shown there are regionally specific decreases in selective muscarinic receptors in the CNS of subjects ...
Elizabeth Scarr, Frank P. Bymaster, Brian Dean   +2 more
openaire   +3 more sources

Muscarinic Acetylcholine Receptors

Current Pharmaceutical Design, 2006
Muscarinic acetylcholine receptors mediate diverse physiological functions. At present, five receptor subtypes (M(1) - M(5)) have been identified. The odd-numbered receptors (M(1), M(3), and M(5)) are preferentially coupled to G(q/11) and activate phospholipase C, which initiates the phosphatidylinositol trisphosphate cascade leading to intracellular ...
Masaru Ishii, Yoshihisa Kurachi
openaire   +2 more sources

The Muscarinic Receptors [PDF]

, 1984
Muscarinic receptors exist in both peripheral tissues and the central nervous system. Their activation is responsible for all the effects elicited by parasympathetic stimulation in the peripheral organs and modulate ganglionic transmission (Wallis, 1979).
Giancarlo Pepeu, Ileana Marconcini Pepeu
openaire   +1 more source

ON THE MUSCARINIC RECEPTORS IN THE URINARY BLADDER AND THE PUTATIVE SUBCLASSIFICATION OF MUSCARINIC RECEPTORS

Acta Pharmacologica et Toxicologica, 1986
Abstract:The muscarinic cholinergic receptors in the urinary bladders of man, guinea pig, rat and rabbit were studied by means of a receptor binding technique, with L‐quinuclidinyl [phenyl4‐3H]benzilate, (‐)3H‐QNB, as radioligand. The potential role of the receptors in the supersensitivity of the rat bladder to muscarinic agonists, following ...
openaire   +2 more sources

Muscarinic Receptor Antagonists

2016
Parasympathetic activity is increased in patients with chronic obstructive pulmonary disease (COPD) and asthma and appears to be the major reversible component of airway obstruction. Therefore, treatment with muscarinic receptor antagonists is an effective bronchodilator therapy in COPD and also in asthmatic patients.
Maria Gabriella Matera, Mario Cazzola
openaire   +3 more sources

Muscarinic receptors in rat uterus

European Journal of Pharmacology, 1994
The aim of this study was to characterise the muscarinic receptor present in the uterus of the virgin rat. Homogenate binding studies were undertaken using [3H]quinuclidinyl benzilate as the radioligand and atropine (10 microM) to determine non-specific binding.
Tracey A. Gillman, Jocelyn N Pennefather, Frederick J Mitchelson   +2 more
openaire   +3 more sources