Results 251 to 260 of about 83,236 (271)
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Regulation of muscarinic M2 receptors
Life Sciences, 1997The molecular mechanisms involved in the regulation of muscarinic receptor gene expression are poorly understood. In an effort to gain a better understanding of the regulation of M2 receptors, we have investigated homologous and heterologous regulation of M2 muscarinic receptor protein and gene expression in human embryonic lung fibroblasts (HEL 299 ...
Jonathan Rousell +2 more
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Muscarinic receptor subtypes in airways
European Respiratory Journal, 1993Muscarinic receptor subtypes in the airways appear to subserve different physiological functions. M1-receptors facilitate neurotransmission through parasympathetic ganglia and enhance cholinergic reflexes, but are also localized to alveolar walls. M2-receptors act as autoreceptors on post-ganglionic cholinergic nerves and inhibit acetylcholine release.
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Endocytosis and recycling of muscarinic receptors
Life Sciences, 1999Agonist stimulation causes the endocytosis of many G protein-coupled receptors, including muscarinic acetylcholine receptors. In this study we have investigated the agonist-triggered trafficking of the M3 muscarinic receptor expressed in SH-SY5Y human neuroblastoma cells.
J. Michael Edwardson, Philip G. Szekeres
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Muscarinic Acetylcholine Receptors
1988The central and peripheral actions of the endogenous neurotransmitter acetylcholine (ACh) are exerted at two main types of receptor, present in both the central and peripheral nervous system of all mammals. Their definition and pharmacological classification dates back to the work of Sir Henry Dale (1914), who demonstrated that certain actions of ACh ...
J. Järv, Tamas Bartfai
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Constitutively active muscarinic receptors
Life Sciences, 2001Mutations that increase constitutive activity and alter ligand binding have been used to investigate the structure and mechanism of activation of muscarinic receptors. These data are reviewed with reference to the recently published three-dimensional structure of rhodopsin.
Ethan S. Burstein, Tracy A. Spalding
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Muscarinic receptors revisited
Trends in Neurosciences, 1983Abstract It is now thought that muscarinic acetylcholine receptors are not identical, and the evidence for this is reviewed briefly, with emphasis on functional studies. In the brain, there is evidence that different subtypes of muscarinic receptors are localized in different regions and there are early suggestions that these may have distinct ...
Malcolm Caulfield, Donald W. Straughan
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Muscarinic receptors in the Mammalian Heart
Pharmacological Research, 2001In the mammalian heart, cardiac function is under the control of the sympathetic and parasympathetic nervous system. All regions of the mammalian heart are innervated by parasympathetic (vagal) nerves, although the supraventricular tissues are more densely innervated than the ventricles.
Chris J. van Koppen +2 more
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CNS muscarinic receptors and muscarinic receptor agonists in Alzheimer disease treatment
This review explores the main aspects that form the basis of the cholinergic-oriented treatment of Alzheimer disease. Muscarinic acetylcholine receptor subtypes in the brain and periphery are discussed. It includes a new and updated overview of the involvement of muscarinic receptors in Alzheimer disease and the recent development of new and highly ...Abraham, Fisher, Allan I, Levey
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Muscarinic receptors in human airways
Journal of Allergy and Clinical Immunology, 1995Muscarinic receptors play a double role in airway disorders, mediating an increase in mucus secretion, as well as constriction of smooth muscle. Cholinergic activity of the lung is more pronounced in large than in peripheral airways; in the nose parasympathetic stimulation leads to hypersecretion and vasodilation.
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