Results 121 to 130 of about 155,151 (336)
Back Again to the Future: A New Era for Cerebroprotection
Annals of Neurology, EarlyView.Cerebroprotection is a fresh framework for designing neurological therapy that targets glia and vascular cells, in addition to neurons. In the future, successful cerebroprotection will involve targeting all elements of the neurovascular unit. Preclinical trials must include functional outcomes, as well as lesion morphometry.
Patrick Lyden
wiley +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Journal of Plant Nutrition and Soil Science, EarlyView., 2023 Abstract Background Plant responses to deficiencies of the micronutrient boron are diverse and go beyond the well‐characterized function of boron in cell wall crosslinking. To explain these phenotypic discrepancies, hypotheses about interactions of boron with various phytohormones have been proposed, particularly auxin.
Michaela S. Matthes +3 more
wiley +1 more source
Effect of Alprazolam and Ketamine on Seizures Induced by Two Different Convulsants
Acta Medica, 1997 Effect of two anticonvulsants with different mechanism of action, i.e. alprazolam and ketamine, was tested in two types of seizure activity.
Josef Herink
doaj +1 more source
Positive surface charge of GluN1 N-terminus mediates the direct interaction with EphB2 and NMDAR mobility. [PDF]
, 2020 Localization of the N-methyl-D-aspartate type glutamate receptor (NMDAR) to dendritic spines is essential for excitatory synaptic transmission and plasticity.
Dalva, Matthew B. +4 more
core +1 more source
Differential role of ventral tegmental area acetylcholine and N-methyl-D-aspartate receptors in cocaine-seeking [PDF]
, 2013 Exposure to drug-associated cues evokes drug-seeking behavior and is regarded as a major cause of relapse. Cues evoke burst firing of ventral tegmental area (VTA) dopamine (DA) neurons and phasic DA release in the nucleus accumbens (NAc). Cholinergic and
Addy, Nii A. +6 more
core +1 more source
Anesthesiology, 2019 What We Already Know about This TopicPresynaptic N-methyl-D-aspartate receptors contribute to opioid tolerance and hyperalgesia as well as neuropathic painThe &agr;2&dgr;-1 protein subunit enhances presynaptic N-methyl-D-aspartate receptor activity What ...
M. Deng +3 more
semanticscholar +1 more source
Hydroxycarboxylic Acid Receptor 2 Mediates β‐hydroxybutyrate's Antiseizure Effect in Mice
Annals of Neurology, EarlyView.A Objective The ketogenic diet, a high‐fat, low‐carbohydrate regimen, is often used to treat drug‐resistant seizures and is being studied for Alzheimer's disease and other neuropsychiatric disorders. However, its mechanism of action remains unclear. β‐hydroxybutyrate, a primary circulating ketone body produced by the ketogenic diet, may mediate its ...
Soudabeh Naderi +10 more
wiley +1 more source
Spermine regulates N-methyl-d-aspartate receptor desensitization
Neuron, 1992 The action of the endogenous polyamine spermine on NMDA-induced responses (in the presence of glycine) was evaluated in cultured spinal cord neurons under voltage- and concentration-clamp conditions. Spermine potentiated NMDA-induced responses in a dose-dependent manner.
openaire +3 more sources
Mental and behavioral disorders and limb twitch for five months
Chinese Journal of Contemporary Neurology and Neurosurgery, 2016 DOI: 10.3969/j.issn.1672-6731.2016.09 ...
Yi SHEN +5 more
doaj