Results 111 to 120 of about 62,513 (217)

A novel selective stabilizer of the ryanodine receptor 2 prevents stress‐induced ventricular arrhythmias without impairing cardiac function

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Aberrant activation of type 2 ryanodine receptors (RyR2) causes lethal arrhythmias, such as catecholaminergic polymorphic ventricular tachycardia (CPVT). Developing drugs that suppress RyR2 hyperactivation may be key to novel arrhythmia treatments.
Nagomi Kurebayashi, Masami Kodama, Hana Inoue, Masato Konishi, Masami Sugihara, Takashi Murayama, Ryosuke Ishida, Koichiro Ishii, Shuichi Mori, Yukari Endo, Xi Zeng, Yukiko U. Inoue, Takayoshi Inoue, Satoru Noguchi, Hajime Nishio, Eri Nakashima, Norio Suzuki, Noriko Nakaya, Ryushi Sato, Yuya Otori, Ayuna Tsutsumi, Mirei Takahashi, Takayuki Oka, Haruo Ogawa, Kayoko Kanamitsu, Hiroyuki Kusuhara, Utako Yokoyama, Junko Kurokawa, Hiroyuki Kagechika, Takashi Sakurai   +29 more
wiley   +1 more source

Promotion of lung cancer growth via glutamate ionotropic receptor N-methyl-D-aspartate-type subunit 2D (<i>GRIN2D</i>). [PDF]

J Thorac Dis
Lv Y, Bu X, Du Z, Zhang Y, Si Y, Shi H, Han L, Bao H.   +7 more
europepmc   +1 more source

Memantine prevents acute stress‐induced memory deficits by reversing sex‐dependent pathophysiological glutamatergic alterations in the dorsal hippocampus

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The neural mechanisms underlying effects of acute stress on memory are poorly understood. We demonstrated previously that acute stress produces identical spatial memory deficits in male and female mice but through distinct molecular mechanisms, with females exhibiting up‐regulation of N‐methyl‐D‐aspartate (NMDA) receptor
Sebastiano A. Torrisi, Lidia Diolosà, Giuseppe Aceto, Claudia Marchetti, Federica Geraci, Konstantinos Partsinevelos, Silvia Rizzo, Margherita Grasso, Filippo Caraci, Francesco Bellia, Giovanni Li Volti, Angela Maria Amorini, Marcello D′Ascenzo, Gian Marco Leggio   +13 more
wiley   +1 more source

Marked response to memantine in refractory chronic migraine. [PDF]

Brain Circ
Nzwalo H, Ramalhete S, Freitas S.
europepmc   +1 more source

A Zeolitic Pyrimidine Framework (ZPF) Nanoplatform Co‐Delivers a DNAzyme and a Protein Prodrug for Cascade‐Activated Tumour Therapy

Cell Proliferation, EarlyView.
A zeolitic framework co‐delivers a DNAzyme and a protein prodrug to tumour cells and executes a self‐amplifying therapeutic cascade: the DNAzyme elevates tumour oxidative stress to activate a caged RNase A prodrug. This spatiotemporally controlled synergy converts a genetic input into potent enzymatic cytotoxicity, suppressing tumour growth.
Yan Huang, Xingjie Hu, Jinli Sun, Min Yin, Nan Chen   +4 more
wiley   +1 more source

Molecular continuity between axon guidance and synaptic function. [PDF]

Mol Cells
Kim S, Cho HJ, Wang IH, Park SJ.
europepmc   +1 more source

Human IDO2 exhibits unique binding affinities distinct to those of human IDO1

The FEBS Journal, EarlyView.
Although indoleamine 2,3‐dioxygenase 2 (IDO2) is highly homologous to IDO1, it displays markedly lower catalytic activity. We found that IDO2 binds L‐tryptophan (L‐Trp) in a flipped orientation stabilized by the IDO2‐specific residue His143. Replacement of His143 with the IDO1‐equivalent tyrosine restored an IDO1‐like binding mode and increased ...
Shunsuke Nogi, Ayumu Takahashi, So Murakami, Nami Adachi, Tina Fujimoto, Yohta Fukuda, Taku Yamashita, Tsuyoshi Inoue, Hirofumi Tsujino   +8 more
wiley   +1 more source

Memantine for Premature Atrial Contractions: A Phase 2 Randomized Clinical Trial. [PDF]

Circulation
Shen Y, Zeng C, Sun Y, Wang J, Yu B, Cheng X, Guo X, Wang DW, Li Y, Han W, Zhou B, Sheng H, Huang Z, Li Y, Fu G, Zhang J, Xie D, Liang D, Liu Y, Yang B, Zhang Q, Duan R, Li H, Zhang B, Wu Y, Zheng L, He J, Liu S, Yin D, Sun G, Zhang S, Guo X, Zhang M, Wang Y, Hu X, Zeng J, Yang X, Li S, Li N, Hu F, Wang H, Hu X, Wang Y, Zeng C, Wang K, Yang J, Wang Y, Lai J, Wang L, Xiong K, Wang G, Zou Q, Shao B, Chen Z, Wu Y, Leng J, Pu J, Ma C, Chen YH.   +58 more
europepmc   +1 more source

Intermediate filaments link glutamate–aspartate transporter deficiency to cochlear synaptopathy

The FEBS Journal, EarlyView.
In a healthy ear, GLAST transporters in supporting cells clear excess glutamate to protect auditory connections. When GLAST is missing, glutamate accumulates and leads to the destruction of structural scaffolding within the postsynaptic nerve endings. This internal collapse causes a loss of synapses that are essential for hearing, ultimately resulting ...
Paul Emmerich Krumpoeck, Lukas David Landegger   +1 more
wiley   +1 more source

UCM-A86 is a selective positive allosteric modulator of GluN1/GluN3 NMDA receptors. [PDF]

Mol Pharmacol
Benton AJ, Johns MR, Diamant E, Rouzbeh N, Sørensen VP, Anderson CM, Secci D, Zhang Z, Rau AR, Clausen RP, Hansen KB.   +10 more
europepmc   +1 more source