Results 111 to 120 of about 119,810 (307)
Transport of BMAA into Neurons and Astrocytes by System x\u3csub\u3ec\u3c/sub\u3e- [PDF]
, 2018 The study of the mechanism of β-N-methylamino-l-alanine (BMAA) neurotoxicity originally focused on its effects at the N-methyl-d-aspartate (NMDA) receptor. In recent years, it has become clear that its mechanism of action is more complicated.
Albano, Rebecca, Lobner, Doug
core +1 more source
Direct Inhibition of N-Methyl-D-Aspartate (NMDA)-Receptor Function by Antiglaucomatous β-Antagonists
Journal of Pharmacological Sciences, 2008 In the present study, we investigated the direct effects of antiglaucoma drugs (timolol, betaxolol, pilocarpine, and latanoprost) on N-methyl-D-aspartate (NMDA)-receptor function using a Xenopus oocytes expression system and electrophysiological ...
Tatsuo Nagata +7 more
doaj +1 more source
Animal Research and One Health, EarlyView.This research innovatively illustrates baicalin’s multifaceted mechanisms in enhancing piglets’ intestinal health: modulating bile acid metabolism via probiotics, reinforcing tight junction proteins (ZO‐1/claudin), suppressing TLR4/NF‐κB‐mediated inflammation, whereas promoting growth and reducing diarrhea.
Yuhui Gao +6 more
wiley +1 more source
Limits of feedback control in bacterial chemotaxis
, 2014 Inputs to signaling pathways can have complex statistics that depend on the environment and on the behavioral response to previous stimuli. Such behavioral feedback is particularly important in navigation.
Dufour, Yann S. +3 more
core +3 more sources
New Therapeutic Strategy for Amino Acid Medicine: Glycine Improves the Quality of Sleep
Journal of Pharmacological Sciences, 2012 Glycine is a non-essential amino acid that has indispensable roles in both excitatory and inhibitory neurotransmission via N-methyl-D-aspartate type glutamate receptors and glycine receptors, respectively.
Makoto Bannai, Nobuhiro Kawai
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Autism Research, EarlyView.ABSTRACT The etiopathogenesis of Autism Spectrum Disorder (ASD) encompasses complex interactions between genetic and environmental risk factors. The high prevalence of gastrointestinal disorders in autistic individuals has propelled a growing interest in the possible involvement of gut dysbiosis in ASD pathogenesis.
Laura Sandoni +6 more
wiley +1 more source
Dual Action of Memantine in Alzheimer Disease: A Hypothesis
Taiwanese Journal of Obstetrics & Gynecology, 2009 Objective: In this study, we proposed a hypothesis to explain the mechanisms of memantine action in treating Alzheimer disease (AD). Memantine may reduce the expression of amyloid precursor protein and tau protein, as well as acting as an antagonist of N-
Tzong-Yuan Wu, Chih-Ping Chen
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British Journal of Clinical Pharmacology, EarlyView.Aims Oral administration of (S)‐ketamine for treatment‐resistant depression (TRD), as alternative to the registered intranasal or off‐label intravenous administrations, has high potential. However, it is characterized by an extensive first‐pass metabolism, resulting in low (S)‐ketamine exposure and high levels of active metabolites, including (S ...
Marije E. Otto +5 more
wiley +1 more source
Retrospective analysis reveals significant association of hypoglycemia with tramadol and methadone in contrast to other opioids. [PDF]
, 2019 Tramadol is one of the most commonly used analgesics worldwide, classified as having a low abuse potential by U.S. Drug Enforcement Agency, and often recommended in pain management guidelines.
Abagyan, Ruben +3 more
core +1 more source
Effect of Alprazolam and Ketamine on Seizures Induced by Two Different Convulsants
Acta Medica, 1997 Effect of two anticonvulsants with different mechanism of action, i.e. alprazolam and ketamine, was tested in two types of seizure activity.
Josef Herink
doaj +1 more source