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Chloral Hydrate's Impact on Brain Development: From Clinical Safety to Molecular Mechanisms. [PDF]

Drug Des Devel Ther
Deng P, Zhu C, Zhang J, Zhu L, Xiao T, Qu S.   +5 more
europepmc   +1 more source

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The N-Methyl-D-Aspartate Receptor Complex

Journal of Receptor Research, 1988
The effects of agonists of the N-methyl-D-aspartate (NMDA) receptor can be blocked by dissociative anesthetics such as phencyclidine (PCP) in a non-competitive manner. This finding together with the fact that ligand binding to the PCP receptor is dependent on the presence of L-glutamate has led to the suggestion that there may exist an NMDA/PCP ...
M, Williams, P A, Loo, D E, Murphy, A F, Braunwalder, M F, Jarvis, M A, Sills   +5 more
openaire   +2 more sources

Deramciclane inhibits N-methyl-D-aspartate receptor function

Brain Research Bulletin, 2000
Effects of the novel anxiolytic drug deramciclane on excitatory amino acid release and transmembrane Ca(2+) ion flux processes were compared in rat cerebrocortical homogenates containing resealed plasmalemma fragments and nerve endings. Deramciclane (10 microM) significantly inhibited [(3)H]D-aspartate release and transmembrane Ca(2+) flux to N-methyl ...
I, Kovács, E, Szárics, N, Skuban, J, Kardos   +3 more
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Assembly of N-methyl-d-aspartate (NMDA) receptors

Biochemical Society Transactions, 2003
The N-methyl-d-aspartate receptor (NMDAR) requires both NR1 and NR2 subunits to form a functional ion channel. Despite the recent advances in our understanding of the contributions of these different subunits to both the function and pharmacology of the NMDAR, the precise subunit stoichiometry of the receptor and the regions of the subunits governing ...
R A J, McIlhinney, E, Philipps, B, Le Bourdelles, S, Grimwood, K, Wafford, S, Sandhu, P, Whiting   +6 more
openaire   +2 more sources

N-methyl-D-aspartate receptors and Alzheimer's disease

Neurobiology of Aging, 1989
The results of several studies now suggest that the density of N-methyl-D-aspartate (NMDA) receptors is maintained in many Alzheimer's disease (AD) cases, although loss of these receptors can occur in specific regions as a consequence of severe neuronal loss.
C W, Cotman, J W, Geddes, R J, Bridges, D T, Monaghan   +3 more
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N-Methyl-D-Aspartate Receptors in the Retina

Molecular Neurobiology, 2006
The vertebrate retina is a "genuine neural center" (Ramón y Cajal), in which glutamate is a major excitatory neurotransmitter. Both N-methyl-D-aspartate (NMDA) and non-NMDA receptors are expressed in the retina. Although non-NMDA receptors and/or metabotropic glutamate receptors are generally thought to be responsible for mediating the transfer of ...
Yin, Shen, Xiao-Ling, Liu, Xiong-Li, Yang   +2 more
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Temperature dependence of N-methyl-d-aspartate receptor channels and N-methyl-d-aspartate receptor excitatory postsynaptic currents

Neuroscience, 2010
N-methyl-d-aspartate (NMDA) receptors (NMDARs) are highly expressed in the CNS and mediate the slow component of excitatory transmission. The present study was aimed at characterizing the temperature dependence of the kinetic properties of native NMDARs, with special emphasis on the deactivation of synaptic NMDARs.
M, Korinek, M, Sedlacek, O, Cais, I, Dittert, L, Vyklicky   +4 more
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Trigeminovascular nociceptive transmission involves N-methyl-d-aspartate and non-N-methyl-d-aspartate glutamate receptors

Neuroscience, 1999
Interest in the fundamental mechanisms underlying headache, particularly the pathophysiology of migraine and cluster headache, has lead to the study of the physiology and pharmacology of the trigeminovascular system and its central ramifications. Cats were anaesthetized (60 mg/kg alpha-chloralose, i.p., along with halothane for all surgical procedures)
R J, Storer, P J, Goadsby
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