Results 261 to 270 of about 119,810 (307)

Assembly of N-methyl-d-aspartate (NMDA) receptors

Biochemical Society Transactions, 2003
The N-methyl-d-aspartate receptor (NMDAR) requires both NR1 and NR2 subunits to form a functional ion channel. Despite the recent advances in our understanding of the contributions of these different subunits to both the function and pharmacology of the NMDAR, the precise subunit stoichiometry of the receptor and the regions of the subunits governing ...
R A J, McIlhinney, E, Philipps, B, Le Bourdelles, S, Grimwood, K, Wafford, S, Sandhu, P, Whiting   +6 more
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N-methyl-D-aspartate receptors and Alzheimer's disease

Neurobiology of Aging, 1989
The results of several studies now suggest that the density of N-methyl-D-aspartate (NMDA) receptors is maintained in many Alzheimer's disease (AD) cases, although loss of these receptors can occur in specific regions as a consequence of severe neuronal loss.
C W, Cotman, J W, Geddes, R J, Bridges, D T, Monaghan   +3 more
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N-Methyl-D-Aspartate Receptors in the Retina

Molecular Neurobiology, 2006
The vertebrate retina is a "genuine neural center" (Ramón y Cajal), in which glutamate is a major excitatory neurotransmitter. Both N-methyl-D-aspartate (NMDA) and non-NMDA receptors are expressed in the retina. Although non-NMDA receptors and/or metabotropic glutamate receptors are generally thought to be responsible for mediating the transfer of ...
Yin, Shen, Xiao-Ling, Liu, Xiong-Li, Yang   +2 more
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Temperature dependence of N-methyl-d-aspartate receptor channels and N-methyl-d-aspartate receptor excitatory postsynaptic currents

Neuroscience, 2010
N-methyl-d-aspartate (NMDA) receptors (NMDARs) are highly expressed in the CNS and mediate the slow component of excitatory transmission. The present study was aimed at characterizing the temperature dependence of the kinetic properties of native NMDARs, with special emphasis on the deactivation of synaptic NMDARs.
M, Korinek, M, Sedlacek, O, Cais, I, Dittert, L, Vyklicky   +4 more
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Trigeminovascular nociceptive transmission involves N-methyl-d-aspartate and non-N-methyl-d-aspartate glutamate receptors

Neuroscience, 1999
Interest in the fundamental mechanisms underlying headache, particularly the pathophysiology of migraine and cluster headache, has lead to the study of the physiology and pharmacology of the trigeminovascular system and its central ramifications. Cats were anaesthetized (60 mg/kg alpha-chloralose, i.p., along with halothane for all surgical procedures)
R J, Storer, P J, Goadsby
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Allosteric Modulation of N-Methyl-D-Aspartate Receptors

1990
In this review we have attempted to describe the basis for current models of the NMDA receptor, and justify the need for the various binding sites that have been proposed. The NMDA receptor is clearly a complex molecule with a number of modulatory sites, any of which may have great functional significance.
I J, Reynolds, R J, Miller
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N-methyl-d-aspartate receptors and pain

Current Opinion in Anaesthesiology, 1995
The N-methyl-d-aspartate subtype of excitatory amino acid receptor is abundantly distributed throughout the central nervous system and is intimately associated with physiologic processes underlying acute and chronic pain states.
Andrew W. Sukiennik, Richard M. Kream
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GRINL1A colocalizes with N-methyl D-aspartate receptor NR1 subunit and reduces N-methyl D-aspartate toxicity

NeuroReport, 2008
We hypothesized that proteins from the GRINL1A complex transcription unit called Gcom proteins modulate glutamatergic neurotransmission through interaction with the NR1 subunit of the N-methyl D-aspartate (NMDA) receptor. Cotransfection of hemagglutinin-tagged Gcom1 (GRINL1A combined transcript 1) and NR1 cDNAs into HEK293 cells revealed overlapping ...
Raymond S, Roginski, Farida, Goubaeva, Maya, Mikami, Emma, Fried-Cassorla, Mohan R, Nair, Jay, Yang   +5 more
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Modeling of N-Methyl-D-Aspartate Receptors

2019
Several reduced kinetic models for N-methyl-D-aspartate receptors were derived in order to suit different experimental protocols. Their simultaneous application allows for a step-wise estimation of parameters of a conventional model that is otherwise overparameterized with respect to the existing data.
Denis Shchepakin, Leonid Kalachev, Michael Kavanaugh   +2 more
openaire   +1 more source

Excitotoxicity and N‐methyl‐D‐Aspartate receptors

Drug Development Research, 1989
AbstractA great deal of new information has been generated over the past decade in the excitatory amino acid (EAA) field. Not only have endogenous EAA such as glutamate and aspartate become recognized as the leading neurotransmitter candidates at the majority of excitatory synapses in the mammalian central nervous system, but it is becoming ...
openaire   +1 more source