Results 241 to 250 of about 25,057,876 (282)

The pharmacology of tacrine at N -methyl- d -aspartate receptors

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2017
The mechanism of tacrine as a precognitive drug has been considered to be complex and not fully understood. It has been reported to involve a wide spectrum of targets involving cholinergic, gabaergic, nitrinergic and glutamatergic pathways. Here, we review the effect of tacrine and its derivatives on the NMDA receptors (NMDAR) with a focus on the ...
Martin Horak, Kristina Holubova, Eugenie Nepovimova, Jan Krusek, Martina Kaniakova, Jan Korabecny, Ladislav Vyklicky, Kamil Kuca, Ales Stuchlik, Jan Ricny, Karel Vales, Ondrej Soukup   +11 more
openaire   +2 more sources

Anti-N-Methyl-d-Aspartate Receptor Encephalitis

The American Journal of the Medical Sciences, 2013
A case of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis with an atypical finding of transient increased intracranial pressure is reported. Anti-NMDAR encephalitis is an underrecognized, novel and treatable form of encephalitis being increasingly identified as an explanation of encephalitis in young adults.
Sian Y, Lim, Ragesh, Panikkath, Charoen, Mankongpaisarnrung, Ebtesam, Islam, Zachary, Mulkey, Kenneth, Nugent   +5 more
openaire   +2 more sources

Temperature dependence of N-methyl-d-aspartate receptor channels and N-methyl-d-aspartate receptor excitatory postsynaptic currents

Neuroscience, 2010
N-methyl-d-aspartate (NMDA) receptors (NMDARs) are highly expressed in the CNS and mediate the slow component of excitatory transmission. The present study was aimed at characterizing the temperature dependence of the kinetic properties of native NMDARs, with special emphasis on the deactivation of synaptic NMDARs.
M, Korinek, M, Sedlacek, O, Cais, I, Dittert, L, Vyklicky   +4 more
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Allosteric Modulation of N-Methyl-D-Aspartate Receptors

1990
In this review we have attempted to describe the basis for current models of the NMDA receptor, and justify the need for the various binding sites that have been proposed. The NMDA receptor is clearly a complex molecule with a number of modulatory sites, any of which may have great functional significance.
I J, Reynolds, R J, Miller
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N-methyl-d-aspartate receptors and pain

Current Opinion in Anaesthesiology, 1995
The N-methyl-d-aspartate subtype of excitatory amino acid receptor is abundantly distributed throughout the central nervous system and is intimately associated with physiologic processes underlying acute and chronic pain states.
Andrew W. Sukiennik, Richard M. Kream
openaire   +1 more source

The N-methyl-D-aspartate Receptor, a Precursor to N-methyl-D-aspartate Receptor Encephalitis, is Found in the Squamous Tissue of Ovarian Teratomas

International Journal of Gynecological Pathology, 2014
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is the most common antibody-mediated limbic encephalitis and is associated with underlying ovarian teratoma. Previous studies suggest that expression of NMDAR on teratoma neural tissue initiates an autoimmune response to NMDAR in the brain.
Rachel M, Clark, Maureen P, Lynch, Rebecca, Kolp, Lawrence R, Zukerberg, Whitfield B, Growdon, Bo R, Rueda   +5 more
openaire   +2 more sources

Spermine regulates N-methyl-d-aspartate receptor desensitization

Neuron, 1992
The action of the endogenous polyamine spermine on NMDA-induced responses (in the presence of glycine) was evaluated in cultured spinal cord neurons under voltage- and concentration-clamp conditions. Spermine potentiated NMDA-induced responses in a dose-dependent manner.
openaire   +3 more sources

Trigeminovascular nociceptive transmission involves N-methyl-d-aspartate and non-N-methyl-d-aspartate glutamate receptors

Neuroscience, 1999
Interest in the fundamental mechanisms underlying headache, particularly the pathophysiology of migraine and cluster headache, has lead to the study of the physiology and pharmacology of the trigeminovascular system and its central ramifications. Cats were anaesthetized (60 mg/kg alpha-chloralose, i.p., along with halothane for all surgical procedures)
R J, Storer, P J, Goadsby
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GRINL1A colocalizes with N-methyl D-aspartate receptor NR1 subunit and reduces N-methyl D-aspartate toxicity

NeuroReport, 2008
We hypothesized that proteins from the GRINL1A complex transcription unit called Gcom proteins modulate glutamatergic neurotransmission through interaction with the NR1 subunit of the N-methyl D-aspartate (NMDA) receptor. Cotransfection of hemagglutinin-tagged Gcom1 (GRINL1A combined transcript 1) and NR1 cDNAs into HEK293 cells revealed overlapping ...
Raymond S, Roginski, Farida, Goubaeva, Maya, Mikami, Emma, Fried-Cassorla, Mohan R, Nair, Jay, Yang   +5 more
openaire   +2 more sources

The role of N-methyl-D-aspartate receptor in Alzheimer's disease

Journal of the Neurological Sciences, 2014
Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive disorder and memory dysfunction. This kind of cognitive impairment is closely related to synaptic plasticity, in which N-methyl-D-aspartate receptor (NMDAR), which is one of the glutamate receptors, plays a critical role.
Junsi, Zhang, Yanna, Li, Jing, Xu, Zhou, Yang   +3 more
openaire   +2 more sources