Melatonin Mitigates Central Sensitization and Nociplastic Pain in Spinal Cord and Dorsal Root Ganglia of FM Rat Model: Modulation of SIRT1/PGC-1α/MAPK/NF-κB Signaling. [PDF]
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Polarity-determined triple partition of dual binding pockets unlocks mechanistic insights and a novel antagonist design of NMDA receptors: a combined MD/DFT study. [PDF]
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Trapped in Silence: Severe Catatonia From Anti-N-Methyl-D-Aspartate (NMDA) Receptor Encephalitis in a Neurofibromatosis Type 1 Patient With Craniopharyngioma. [PDF]
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Targeting Ferroptosis and Necroptosis to Treat Stroke. [PDF]
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Selective Modulation of the GluN2B/C/D Containing <i>N</i>‑Methyl‑d‑Aspartate Receptors: A New Frontier in Targeted Neurotherapeutics. [PDF]
Li Y, Liang SH.
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The N-Methyl-D-Aspartate Receptor Complex
Journal of Receptor Research, 1988The effects of agonists of the N-methyl-D-aspartate (NMDA) receptor can be blocked by dissociative anesthetics such as phencyclidine (PCP) in a non-competitive manner. This finding together with the fact that ligand binding to the PCP receptor is dependent on the presence of L-glutamate has led to the suggestion that there may exist an NMDA/PCP ...
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Deramciclane inhibits N-methyl-D-aspartate receptor function
Brain Research Bulletin, 2000Effects of the novel anxiolytic drug deramciclane on excitatory amino acid release and transmembrane Ca(2+) ion flux processes were compared in rat cerebrocortical homogenates containing resealed plasmalemma fragments and nerve endings. Deramciclane (10 microM) significantly inhibited [(3)H]D-aspartate release and transmembrane Ca(2+) flux to N-methyl ...
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