Results 131 to 140 of about 60,310 (240)

The microbiota–gut–brain axis in Huntington's disease: pathogenic mechanisms and therapeutic targets

The FEBS Journal, Volume 292, Issue 6, Page 1282-1315, March 2025.
Disturbances of the microbiota–gut–brain axis are evident in people with Huntington's disease (HD) and in HD animal models. Here, we provide an overview of how the trillions of microorganisms residing in the gut, their secretory products, and the microbiota–gut–brain axis may contribute to HD pathogenesis.
Millicent N. Ekwudo, Carolina Gubert, Anthony J. Hannan   +2 more
wiley   +1 more source

Obesity and the gut microbiota: implications of neuroendocrine and immune signaling

The FEBS Journal, Volume 292, Issue 6, Page 1397-1420, March 2025.
An unhealthy diet impairs the symbiotic relationship between the gut microbiota and the host, contributing to obesity. At the intestinal level, identification of host–microbe events essential for proper neuroendocrine/immune signaling is key to the development of microbiome‐based strategies to promote metabolic health in obesity (probiotics ...
Marina Romaní‐Pérez, Rebeca Líebana‐García, Alejandra Flor‐Duro, Daniel Bonillo‐Jiménez, Clara Bullich‐Vilarrubias, Marta Olivares, Yolanda Sanz   +6 more
wiley   +1 more source

I "Gut" Rhythm: the microbiota as a modulator of the stress response and circadian rhythms

The FEBS Journal, Volume 292, Issue 6, Page 1454-1479, March 2025.
The stress response and circadian rhythms are essential to maintain appropriate responses to the environment and are known to be impacted by the gut microbiota. Due to the interconnected nature of these important components of physiology, in this review we explore how the gut microbiota may play a role in regulating the integration of stress and ...
Gabriel S. S. Tofani, Gerard Clarke, John F. Cryan   +2 more
wiley   +1 more source

Succinate receptor 1 signaling mutually depends on subcellular localization and cellular metabolism

The FEBS Journal, Volume 292, Issue 8, Page 2017-2050, April 2025.
SUCNR1, activated by succinate, is a Gi‐ and Gq‐coupled receptor present at the plasma membrane and in endosomes. There are conflicting reports about the pro‐/anti‐inflammatory effects of the succinate‐SUCNR1 signaling axis, and these are likely due to localization‐dependent signaling.
Aenne‐Dorothea Liebing, Philipp Rabe, Petra Krumbholz, Christian Zieschang, Franziska Bischof, Angela Schulz, Susan Billig, Claudia Birkemeyer, Thanigaimalai Pillaiyar, Mikel Garcia‐Marcos, Robert Kraft, Claudia Stäubert   +11 more
wiley   +1 more source

Estrogen synthesized in the central nervous system enhances MC4R expression and reduces food intake

The FEBS Journal, EarlyView.
Estrogen is regulated by the rate‐limiting enzyme aromatase. This study examines how neuroestrogens, estrogen produced in the brain, regulate appetite through the hypothalamus. Using ovariectomized, aromatase knockout, and brain‐specific aromatase‐restored mice, the study found that neuroestrogens suppress appetite by influencing genes like Mc4r.
Takanori Hayashi, Kanako Kumamoto, Tatsuya Kobayashi, Xinfeng Hou, Shizuko Nagao, Nobuhiro Harada, Shinichiro Honda, Yohei Shimono, Eiji Nishio   +8 more
wiley   +1 more source

A post hoc analysis of migraine‐associated symptoms from the phase 3 randomized, double‐blind, sham‐controlled Trial of External trigeminal nerve stimulation for the Acute treatment of Migraine (TEAM) study

Headache: The Journal of Head and Face Pain, Volume 65, Issue 5, Page 779-790, May 2025.
Abstract Background The Trial of External trigeminal nerve stimulation (eTNS) for the Acute treatment of Migraine (TEAM) study demonstrated that eTNS use during active migraine resulted in significantly higher rates of resolution of migraine‐associated most bothersome symptom (MBS) compared to sham.
Gregory A. Panza, Michael A. L. Johnson, Deena E. Kuruvilla   +2 more
wiley   +1 more source

Antimicrobial Neuropeptides and Their Receptors: Immunoregulator and Therapeutic Targets for Immune Disorders. [PDF]

Molecules
Chen K, Wu X, Li X, Pan H, Zhang W, Shang J, Di Y, Liu R, Zheng Z, Hou X.   +9 more
europepmc   +1 more source

Low serum 25‐hydroxyvitamin D levels in migraine are not related to headache frequency: A case‐control study in patients with high‐frequency/chronic migraine

Headache: The Journal of Head and Face Pain, Volume 65, Issue 5, Page 863-870, May 2025.
Abstract Background Serum 25‐hydroxyvitamin D (25[OH]D) concentrations have been shown to be low in patients with migraine, but results are controversial regarding the current role of vitamin D in migraine severity. Using a case–control design, we aimed to evaluate serum 25(OH)D levels in a group of females with high‐frequency episodic migraine/chronic
Marina Haro, Gabriel Gárate, José Luis Hernández, José Manuel Olmos, María Muñoz, Vicente González‐Quintanilla, Julio Pascual   +6 more
wiley   +1 more source

Neuropeptides as regulators of bone metabolism: from molecular mechanisms to traditional Chinese medicine intervention strategies. [PDF]

Front Pharmacol
Lin Q, Zhao B, Huang J, Chen R, Sun W, Ye Q, Yang L, Zhu X, Li X, Zhang R.   +9 more
europepmc   +1 more source

Development and pharmacological characterization of novel multi‐ calcitonin gene‐related peptide and pituitary adenylate cyclase‐activating peptide receptor antagonists

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective This study aimed to provide proof‐of‐concept that multi‐receptor antagonist peptides can be generated by covalently linking independent antagonist peptides that block calcitonin gene‐related peptide (CGRP8‐37) or pituitary adenylate cyclase‐activating peptide (PACAP)/vasoactive intestinal peptide (VIP) (PACAP6‐38) activity ...
Zoe Tasma, Andrew Siow, Paul W. R. Harris, Margaret A. Brimble, Debbie L. Hay, Christopher S. Walker   +5 more
wiley   +1 more source